Ahamed › Likes

"10.1002/anie.201105123" Combination of Cu and DDQ, but not surprising given Li's example of a similar reaction with alkynes. - Matthew Todd from Bookmarklet

Thanx for citing the Blue Obelisk paper! - Egon Willighagen

Of course! - Matthew Todd

Like like like like like. :-) - Bill Hooker

OK, NMR thread forked here: https://plus.google.com/1149590... - Matthew Todd

read more

Is it your group who are going to run the assays or someone in India? - Andrew Lang

Well, assays can of course we run by anyone. We have a couple of excellent labs lined up for this - one is Eskitis in Queensland, and the other is the Ralph lab at Uni Melbourne. The main bottleneck is at this point synthetic medicinal chemistry. - Matthew Todd

Bradner appealing for open source style help with drug optimization. - Matthew Todd from Bookmarklet

10.1039/C1SC00026H. Ahamed. Doyle. - Matthew Todd from Bookmarklet

Cyclization via Pictet-Spengler reaction gave diastereo-enriched dihydroisoquinolines which can be separated and converted to the enantiopure product - Michael Wolfle

Hmm, it could be possible if the synthesis of the isocyanide works - see here: http://www.ourexperiment.org/racemic... - Michael Wolfle

Were we not just talking about this in the pub? - Matthew Todd

Talks from OSS are available - Matthew Todd from Bookmarklet

Great explanation from Morgan Langille about #BioTorrents - Mike Chelen

CDC. 10.1002/ejoc.201000548. Althea, Soo. N-Boc works. They also use the Soo "dimer" in a reaction. - Matthew Todd from Bookmarklet

10.1039/C0CC01487G. Pretty. Very selective N-methylation, presumably discovered as a byproduct from a debenzylation reaction. This must be known, but the selectivity is still very nice. - Matthew Todd from Bookmarklet

So MeOH ------> HCHO which then forms imine and this imine gets reduced under Pd/C, H2 conditions. The first part is strange. - Ahamed

Fantastic! It just keeps getting better as it goes on. - Chris Lasher

They killed the original song. - Ahamed

"The Commonwealth gave Sydney University $750 million in grants in 2009 – before you get to HECS payments and student fees. About $200 million a year goes to the faculty of medicine for research. Those funds employ a small army of very clever men and women in trying to solve human health-related problems. Sydnovate's sole purpose is to commercialise the good ideas that this army of researchers (and their colleagues in the faculties of engineering, chemistry, etc) create. So what is the royalty return that we taxpayers get for $750 million a year? It's $2.5 million in 2009 out of total university revenue of $1.4 billion – or one-third of 1 per cent. After 160 years of operation, Sydney University makes more money selling beer and hamburgers to students than it does licensing intellectual property." - Matthew Todd from Bookmarklet

10.1007/s11426-010-4069-x, Ahamed - zinc plus organocatalyst for aldol - Matthew Todd from Bookmarklet

thanks, there is a good increase in ee when Zn(OTf)2 was used in combination with chiral catalyst, however the yields havent changed which is strange. - Ahamed

Preparation of Chiral Praziquantel read more

Article from a few years back from Whitesides giving advice from his group on how to write a paper. - Matthew Todd from Bookmarklet

"10.1021/ol101576q" Althea - use of dimethylaniline substrates, here in an Ugi-like process, but the principle remains the same. Cu plus a ligand plus peroxide. - Matthew Todd from Bookmarklet

A nice reaction to explore its asymmetric version. Chiral Py-BOX?? - Ahamed

Nice - Matthew Todd

"The Nobel laureate John Cornforth said it well: he defined the perfect synthesis as one which could be done by a one-armed operator by pouring down a mixture of chemicals down a drain and collecting the product in one hundred percent yield and stereoselectivity at the other end." - this is what we are doing with most of our projects with PZQ. I love this definition. - Ahamed

Can anyone who's been with me in the pub recently confirm that I predicted this Nobel prize correctly? - Matthew Todd

Yes Yes it was spot-on. Well predicted. - Ahamed

"“Schistosomiasis is a far more important disease than we ever realized,” said Peter Hotez, one author of the commentary and the chairman of the department of microbiology, immunology, and tropical medicine at The George Washington University. “The failure of the global community to provide access to this essential medicine is impeding sustainable development in Africa.”" - Matthew Todd from Bookmarklet

"10.1002/chem.201002046" Published. - Matthew Todd from Bookmarklet

The long awaited Domling paper on the Ugi synthesis approach to praziqantel. The yield is reported as 100% in a scheme, it is 98% in the experimental section. I would like to see the NMR of that product but it isn't in the supplementary materials. We've never seen any Ugi reaction that close to quantitative. Also no mention of whether a precipitate forms. - Jean-Claude Bradley

Well look at that - another anthelmintic where one enantiomer is active and where the structure is based on a chiral vicinal diamine! - Matthew Todd from Bookmarklet

Sound advice, though I also skimmed it. - Matthew Todd from Bookmarklet

pq: "While real scientific papers don't follow the strict "Abstract-Introduction-Procedure-Results-Conclusion" format" WTF?? - Björn Brembs

Good collection of books for writing and presentations. - Ahamed