"Doesn't it depend on what you're attempting to do, there's a lot of focus on producing apps but I think @fredwilson calls it right when he says focusing on the mobile web first (http://www.avc.com/a_vc...) forces you to simplify the UI. @adactio (http://adactio.com/journal...), @jamespearce (http://tripleodeon.com/2010...) and @bryanreiger (http://yiibu.com/article...) all have some interesting things to say on how you might do that...." - Andy Davies