Cyndy Parr tweets ( http://twitter.com/cydparr... ) "This is kind of what PLOS One envisions -- it goes up there, and then it could get chosen to be part of a hub". Iz true?
- Karen James
Thanks, Graham. Having just had a paper rejected by two journals in a row, I'm fed up to here *points to own eyebrows* with spending hours if not days re-formatting to meet the ridiculously precise but in no way substantive guidelines of different journals. It's not even rewriting, it's just pointless fiddling and a silly waste of time. If the taxpayers only knew...
- Karen James
There are two issues at hand here. One, a universal format for submission, Two, a bidding process on papers. The Neuroscience Peer Review Consortium points to how the second part of this kind of deal is working right now in some disciplines (http://nprc.incf.org/), the really really sad part about the first issue here is that the big publishers don't care what format you submit in (let...
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- Ian Mulvany
+1 for more standards for paper submissions, starting with reference styles. And for allowing submissions in the NLM DTD format.
- Martin Fenner
Ian, you may say they don't care, but when one is submitting a manuscript, one is trying to do everything one can not to give the publisher any possible little excuse to reject your paper without review.
- Karen James
Second time in a week that someone stated "publishers don't care about format of submissions". Again I ask: if that's the case, why do all journals make a huge deal about it in their instructions to authors?
- Neil Saunders
As for universal format: easily solved by writing our papers on the web. Imagine a simple forms-based interface with fields for title, authors, abstract, introduction... Imagine a button in Google Docs that says "submit this document to <insert journal here>" !! But currently, we all like to use our own word-processing software on our own machines, then upload a document in a multitude of formats. It's going to take a big shift in thinking and work practices.
- Neil Saunders
What Neil said: if journals don't care, why do they make such a damn song and dance about it? Why not explicitly say you can *submit* in any basic AIMRAD format? Worry about format after acceptance: either the journal can send it to India per Ian above, or if they make the authors do it at least they only have to do it once. My next paper (quit laughing) is going out in basic AIMRAD...
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- Bill Hooker
Note: this is easier for me to do than many, because I've basically given up on an academic career as currently constructed.
- Bill Hooker
"it's just pointless fiddling and a silly waste of time. If the taxpayers only knew" I think they should / deserve to know!
- Björn Brembs
+1 Neil "why do all journals make a huge deal about it in their instructions to authors?" and +1 Björn "I think [the taxpayers] should / deserve to know!"
- Karen James
Neil & Bill: maybe "don't care" is to strong a phrase. A manuscript does need to be structured correctly to fit into the journal's content management system (an application note looks different to a letter looks different to a research paper), have images properly resized and references in the right format so that they can be processed by systems that convert to them links etc.
- Euan
Also: what happened to that Wolfram word processor for papers that was supposed to do what Neil mentioned above with Google Docs?
- Euan
the publishers i know would be delighted to standardise to NLM DTD for submissions -- would save lots of editorial time and production costs -- the publisher i know best sends accepted papers to be manually turned into xml which can then be used for PMC deposition and the semi-automatic generation of the HTML and PDF versions. But things like the Publicon app have taught publishers that implementing the technology to do something doesn't mean that it will happen in significant quantities! :)
- Joe Dunckley
I used Publicon when it was released a few years ago. Essentially a dead product now. Lemon8-XML does what Neil describes as "Imagine a simple forms-based interface with fields for title, authors, abstract, introduction... ": http://network.nature.com/people....
- Martin Fenner
There is a nascent version of that working in neuroscience http://nprc.incf.org/. Journals have formed a consortium where if an author submits to one journal and it gets rejected, the author can specify that the reviews follow the paper to another journal so that it doesn't need to be re-reviewed. This was viewed as a way for papers that have nothing wrong with them but which don't fit the scope of the journal can be published more quickly and easily.
- Maryann Martone
What about replacing "papers" and "journals" in the subject line with "proposals" and funders?
- Daniel Mietchen
What if journals said here's our LaTeX template. Put the right text in the indicated field, lotion in the basket, and anything else won't be accepted.
- Mr. Gunn
@Daniel Mietchen: Yes, that too! @Mr. Gunn: What I'm advocating is that there's a single LaTeX (or whatever) template - not that you'd re-paste for each journal.
- Karen James
karen, yes. The idea being you give them the text and they do whatever they like with the formatting.
- Mr. Gunn
Aside from making life easier for authors, it would allow sane computational use of papers. With PDF, you don't even know which image a figure legend refers to, except by guess work. The difficulty is that the journals don't see it as their problem. The solution is for the authors to make it the journals problem
- Phil Lord
I like the idea, Karen. Publishing an exciting paper should not a be a torture (for us!)
- Betül
Getting access to research papers is already too expensive. Wouldn't it just be more so if we invited a bidding war on each paper? Write good papers, and submit them to PLoS.
- Ted Slater
I'd like something similar for the review process. Instead of having to register for each journal/publisher managing logins and passwords for each, have a clearing house that manages reviewer information that the journals subscribe to.
- John Hogenesch
Fascinating letter of recommendation written by Robert Oppenheimer, in which a young Richard Feynman is described as "a second Dirac, only this time human" - http://origin.reddit.com/r...
(ego) A while ago it was requested to use Open Access when possible to get the papers. After three of us tried to navigate the DOI, PubMed, and various publication systems we pretty much gave up on trying to figure out how to do it with all of the different systems and numbers. Enter another bioinformatician from CEPH, who not only partially solved the problem but shared his method, which I can use to accomplish something similar.
- Pierre Lindenbaum
Genome Biology, Vol. 10, No. 11. (2009), R130. Online gene annotation resources are indispensable for analysis of genomics data. However, the landscape of these online resources is highly fragmented, and scientists often visit dozens of these sites for each gene in a candidate gene list. Here, we introduce BioGPS (http://biogps.gnf.org), a centralized gene portal for aggregating distributed gene annotation resources. Moreover, BioGPS embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform. Chunlei Wu, Camilo Orozco, Jason Boyer, Marc Leglise, James Goodale, Serge Batalov, Christopher Hodge, James Haase, Jeff Janes, Jon Huss, Andrew Su
- Neil Saunders
one of those authors seems familiar :-)
- Neil Saunders
Nucl. Acids Res. (6 November 2009), gkp937. Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug-target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74 000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/. 10.1093/nar/gkp937 Michael Kuhn, Damian Szklarczyk, Andrea Franceschini,...
- Neil Saunders
I didn't expect the paper to come out this quickly, I was quite surprised to see it in my feed reader on the weekend. I have now activated STITCH 2 as public website ... hope it's not too buggy :)
- Michael Kuhn
umm .. you are going to make me re-do some work :p
- Pedro Beltrao
@Michael - quick questions: I don't think I ever saw homology evidences in the drug-gene interactions. Do you guys avoid doing this or it is just not reported in the evidence info ?
- Pedro Beltrao
@Pedro: going from STITCH 1 to 2 will change the identifiers of proteins and chemicals, so check first if you run into trouble there
- Michael Kuhn
re transfer: if you are in human or mouse, you probably won't see so much transfer. but if you go to e.g. chimp, you'll see a lot of transferred evidence
- Michael Kuhn
"For those who want to take a glimpse at where science and scientific discourse are going, take a look at some of the papers at this workshop"
- Bill Hooker
from Bookmarklet
Me too, re: Google Wave gadget. Then add SBML support, use SBGN in the display, support MIRIAM annotations and I can retire penniless.
- Neil Swainston
@Neil, there are a few other tools which support SBML and SBGN (see http://sbgn.org/Communi...). Wikipathways seem to be inventing yet another pathway format and dont provide a conversion to any other existing "standard". Shame as it would benefit everyone if they did.
- Frank
Thinking about it a little more, I'd really like to see the above refactored as a collaborative Google Wave Gadget. I've been involved in about five network reconstruction "jamborees" now, which involve flying loads of people around the World to sit in a room and discuss things that they could do with PathVisio (if it supported SBML...) or Payao. Anyways, this costs a fortune (see the...
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- Neil Swainston
@Neil: WikiPathways is intended exactly for that type of collaborative pathway creation. WikiPathways pathway format is based on, and developed in cooperation with, http://www.genmapp.org. So admittedly it's not a widely supported standard, but at least it wasn't a complete new invention. SBML / SBGN support is on its way. Re Google Wave: unfortunately, all this work predated Google Wave by several years...
- Martijn van Iersel
Oh bother - talking to NAR about writing something on data licensing was on my list of things to do from last year. Guess I missed the boat again :-(
- Cameron Neylon
Cameron: don't worry, data licensing will not stop being in need of explanation any time soon ;D
- Mike Chelen
Why thankyou Mike, you really know how to brighten my day up...
- Cameron Neylon
These end up being a bit of a monster so require decent upload bandwidth to get them up there. My poor home connection is struggling somewhat.
- Cameron Neylon
So you're claiming it took 5 days to upload them? :-) Did you see the video? http://bit.ly/3J0vyS Shame you didn't go "Beep" when you changed the slide so people could follow along ;-)
- AJCann
@ajcann Richard has a very annoying doorbell noise he adds to his slide transition, keeps the students awake and then he uploads with mp3 audio recording of the presentation, so you can join the two together. I think he's the only person still using our mp3 recorders from the techdis project!
- Jo Badge
Nope. I'm claiming I didn't have a decent internet connection till yesterday and thought I deserved at least one day of rest :-) Hmmm, wonder if you could set up a high pitched sound off the computer that would be picked up by the camera but not audible? I might try and pull the audio off the video and see if I can do a slidecast at some point. I haven't watched much of the video though - can't stand watching myself...
- Cameron Neylon
I usually do a shortened mp3 for my talks which I sync up on Slideshare before the talk. I suspect people are less tolerant of me droning on online than during a talk. I know I am. As Guy Kawasaki says of PowerPoint presentations with too much text, I can think faster than this bozo can talk.
- AJCann
That's true - hence I try to put enough text on the slides to make them more or less self sufficient. Doesn't always work of course. Especially if there is a big chunk of live demo missing...
- Cameron Neylon
If we're to get continued funding, and support JBrowse to meet all the
requests that you have justifiably demanded, it's absolutely critical
that we demonstrate an overwhelming demand for JBrowse from the user
community -- that means you. http://sourceforge.net/mailarc...
"Also, in another subproject of the same grant, we plan to develop a JBrowse version of the GBrowse_syn synteny viewer developed by Sheldon McKay, so you can browse syntenic regions of homologous genomes side-by-side." definitely convinced me that a letter is in order.
- Paul J. Davis
I think I am finally beginning to get my head round this. Got my self a desktop notifier, the iPhone skin for my itouch is really clear, picking up some new subscriptions and dumping my tweeters back into the twitterverse :-)
- Jo Badge
from iPod
[Image: "network" by Simon Cockell, link to original source for attribution] In particular, what are you using to view networks in a dynamic way? Cytoscape seems the behemoth for visualizing biological networks, but have you used other solutions? A group mate and I have been discussing how we could *really* use a JavaScript library that rendered as SVG in a web browser. This would allow us to call for more data from our databases and present data on the fly and only-as-needed. He's convinced we could start writing one; I'm concerned it's a lot more difficult than he thinks, but we're both fishing for other ideas.
- Chris Lasher
from Bookmarklet
We're using Raphael in the Protein Geometry Database <http://pgd.science.oregonstate.edu/> for rendering our graphs. It's been a huge boon to cross-browser compatibility since IE *still* can't do SVG.
- Donnie Berkholz
You might try a particle demo on Chromium's canvas element. Other than that I think the optimizations for performance could end up being the bigger project. Not undoable, just maybe not worth the time. Also, specifically Chromium as they're canvas element is current the best, though hopefully FF and Safari aren't too far behind. For IE, just give them a link to Chrome Frame ;)
- Paul J. Davis
Is this meant for big graphs? Is the focus on layouts etc? Prefuse is a pretty nice toolkit for graph layout/calculations. igraph also is an excellent library with a bunch of layout algos
- Rajarshi Guha
Many thanks for your input, guys. @Rajarshi We have graphs of 5k-12k nodes and 20k-80k edges. I don't know if that counts as large but they're not small. @Paul I'm worried about performance (responsiveness) given that Firefox can take a pounding in some of the demos at http://www.chromeexperiments.com. That's why I wonder if Cytoscape is really the only option (right now). @Mike and...
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- Chris Lasher
Thanks, Chris! I certainly hope it enables some folks to do interesting science instead of just looking pretty, though. =)
- Donnie Berkholz