like Greasemonkey for movies, removing fan irritations like Rose in Titanic, Kirk in Star Trek Generations, and the plot of the Matrix sequels
- Andy Baio
"This is my personal account of curing my asthma and hayfever by deliberately infesting myself with the intestinal parasite hookworm. It isn't for the faint hearted and for some should not be read while eating. It involves a great deal of research, a trip to Cameroon and a lot of barefoot walking in open air latrines in west Africa. If you have asthma, or know someone who has asthma (or for that matter Crohn's disease, IBD or colitis) and are suffering badly you owe it to yourself to consider this approach. Because although it sounds strange and is repellant it is founded on sound science and it has one other virtue. It worked."
- Paul Buchheit
from Bookmarklet
Apparently some populations are more likely to have sickle cell anemia because of the mutation that protects them from malaria.
- Kevin Fox
I read this article a couple years ago (it's from 2006), and there's an article in the NY Times about it: http://www.nytimes.com/2008... Apparently they've tested it, and it works.
- Tanath
This paper (Asthma and Current Intestinal Parasite Infection Systematic Review and Meta-Analysis): http://66.102.1.104/scholar... says "hookworm infection was associated with a significantly strong reduction that was directly and significantly related to infection intensity" & "Conclusions: Parasite infections do not in general protect against asthma, but infection with hookworm may reduce the risk of this disease."
- Tanath
I suffer from asthma, and I don't think I want worms inside me.
- imabonehead
Then I guess you'll have to wait until they figure out how hookworms do the trick, and then turn it into something that can be mass-marketed, which gets tested in clinical trials, and then approved by the FDA, and the prescribed by your doctor... several years from now.
- Tanath
The hygiene theory of asthma http://www.ncbi.nlm.nih.gov/pubmed... posits that the subsystem of your immune system that takes care of parasites becomes hyperactive, because in urban industrialized settings we no longer get the feedback from environmental exposure, which would normally reign it in. The hyperactivity of this subsystem is what is responsible for allergies and asthma.
- Victor Ganata
Victor: I don't think it's quite that simple. The meta-analysis paper notes that in general, parasites don't help with asthma, and some make it worse. Hookworms were the only ones noted to actually help.
- Tanath
Tanath, heh, yeah, it's definitely not as simple as that, but that's the gist of the hygiene theory, which has been one of the dominant paradigms when discussing allergic and autoimmune diseases. Meta-analyses always need to be taken with a grain of salt. Ideally, someone would do an adequately powered prospective trial to retest it, but I imagine it'll be difficult to get enough subjects to volunteer to be deliberately infected with parasites.
- Victor Ganata
Jess: That would be one way to do it... LOL. I'm sure there's other ways, but if not... could still be worth it. Better to know about the option, anyway. LOL, Cristo!
- Tanath
wouldn't it be great to go back in time 60, 70 years and explain that in the 21st Century, infecting yourself with hookworms is considered cutting-edge medicine. also leeches are used in microsurgery and reconstructive surgery. medicinal maggots are used to destroy necrotic tissue. and people pay extra money for food and drink that have been loaded up with gut bacteria (probiotics). also, we believe in bodily humors called "neurotransmitters" :-D
- Karim
Cristo, yeah, when you put it that way, the 21st Century looks pretty incomprehensible. :-D "see, Twitter is like the wireless, only everybody sends short messages about what they are eating... no, really, the company is valued in the billions of dollars...."
- Karim
I think I'd rather just have hay fever, man. (Well, assuming this works, it's also a shame there isn't some way to create hookworm-filled capsules that could directly deliver the works to the GI tract...)
- Andrew C (✓)
Well, if the theory is right, the hookworm has to enter the bloodstream in order to fully activate the cascade of signaling molecules, which the hookworm can't do directly from the gut. I'm thinking that if they figure this out, they'll probably be able to just remove the actual hookworm from the equation, and just manipulate the appropriate molecules and receptors to stimulate certain pathways and inhibit others.
- Victor Ganata
Ah. Then I definitely would prefer to just have hay fever and deal with it with the regular allergy medication for now.
- Andrew C (✓)
Have you heard the story of Jeff Hawkins carrying around a block of wood as he was thinking about the Palm Pilot, Kevin?
- Ken Sheppardson
I actually hadn't, but I see that the Omni Group has made iPad mockups to better understand how they should design their iPad apps: http://blog.omnigroup.com/2010...
- Kevin Fox
like the Phantom Menace, the lack of constraints can lead to disaster
- Andy Baio
A reminder that the #1 feature for any software project is to "ship it!" Effective teams always have somebody rallying coworkers to get the project out the door.
- Chris Prince
from Android