#cshl David Goode (Stanford) implications: (1) we should use constraint rather than annotation to prioritise functional sites; (2) don't ignore non-coding regions (>90% of functional variation is here); (3) most functional variation is shared between populations; (4) next-gen genotyping platforms should target constrained sites
Philip Awadalla on sequencing of synaptic genes in autism and schizophrenia: (1) de novo mutations explain some cases of both diseases, but many are cell line artifacts; (2) excess of rare mutations in synaptic genes in both disease; (3) same gene can be linked to both diseases
Peter Donnelly on analysis of CNVs in seven different diseases: (1) most CNVs (especially >10% frequency) are already well-tagged by SNPs; (2) CNV analysis EXTREMELY challenging due to technical artifacts (e.g. systematic diff between blood/cell line DNA); (3) many of these technical artifacts would survive replication; extreme caution required!
Maria Wilbe on benefits of using the dog for mapping complex traits: (1) same genes and diseases as human; (2) inbred breeds mean very long haplotypes, making genome-wide association easier; (3) much shorter shared haplotypes BETWEEN breeds makes subsequent fine-mapping easier.