Homologous recombination in human cells using artificial restriction DNA cutter... [Chem Commun (Camb). 2009] - PubMed result - http://www.ncbi.nlm.nih.gov.li...
Show ability to cut a specific, single region of human genome. Probably an incredibly useful technology, related to what Cameron was telling us about last week. Linked to me by F1000 and reviewed there by Scott K Silverman
- Steve Koch
"Boing Boing Video proudly debuts "Meet The Elements," a new animated music video from They Might Be Giants. This animated, upbeat ode to the periodic table of elements and how they form our world, appears on the new TMBG kids' album "Here Comes Science." Video directed by Feel Good Anyway."
- Mike Chelen
from Bookmarklet
I sent this whole set to my kid's elementary science teacher -- she has to buy the CD b/c the school's internet blocks Youtube -- but I had a great 45 minutes listening to them. I also really liked the one about the sun.
- Mickey Schafer
cool, going to look for the rest of the album, only heard this song so far. would be nice if students and teachers could use more free internet resources, glad they got access to interesting media like this in the end :)
- Mike Chelen
Was an awesome day. Thank you so much for traveling and spending time with us today, Cameron! I learned a lot about science and means for carrying out open science. I'm energized about what seems like a very nice future protein-DNA collaboration. And I'm also energized about trying to implement some of the LaBlog and Google wave things you demoed for us.
- Steve Koch
I agree it was a great visit. I enjoyed showing you the version of the $100 spectrometer I'm working on and all the great conversation. I hope KochLab can start a collaboration with our friends across the pond.
- Andy Maloney
from iPhone
I think I'm going to put some nuggets of information from today onto this thread. Here is a link to the Neylon, Ward, Towrie, and Parker Tus-Ter single-molecule proposal (linked in Cameron's open notebook; see PDF at the bottom): http://blogs.chem.soton.ac.uk/sortase... I think that the system they are studying fits...
more...
- Steve Koch
I started learning more acronyms having to do with open and linked data. RDF = Resource Description Framework http://en.wikipedia.org/wiki... There was some other acronym that I can't remember or find that Cameron was suggesting as a way of bundling an entire open data set of arbitrary format...lots of vowels, something like OAI... "open access...? NOTE...
more...
- Steve Koch
Cameron showed us some of the robots he and others have programmed for Google Wave. I learned that it's not crazily complicated to write a robot, and that you can use Google App Engine (http://code.google.com/appengi...) to host your code and run the robot. It currently runs Python and now Java. I still don't understand how it connects with Wave, but it solves a mystery to me of...
more...
- Steve Koch
(Coincidentally (or maybe not), right after waving with Cameron, Google Wave gave me my 20 invites to send out. Let me know if you need one!)
- Steve Koch
I'm sure Cameron and others have already said this in their many fantastic presentations and blog posts about wave. But I was happy to hear Cameron agree with my thinking that google wave + robots would be a very good way of handling data analysis workflows. When we process unzipping data, there are a few layers of software involved. I imagine each software application being run in the...
more...
- Steve Koch
Cameron's current LaBLog at Rutherford can be found here: http://biolab.isis.rl.ac.uk/cameron... Hopefully I'll be able to get access to this to see the edit features (I "requested" an account by logging in with my yahoo openid). I had previously been impressed by the notebook, but today was really wowed when I saw him edit a new entry. The particular things was the ability to...
more...
- Steve Koch
+1 for a Wave invite, please (pmiller@liv.ac.uk).
- Peter Miller
That's wonderful that Cameron visited your lab Steve! For all the usefulness of communication technologies nothing can replace a productive meatspace interaction.
- Jean-Claude Bradley
I had a great time - meeting and talking with Koch and the team. Lots of very cool stuff going on and lots of ideas that just seemed to bubble out of it. The meatspace interaction is really important but having that bit of background about what was going on and the context and trust built up here on Friendfeed amongst other places makes the whole discussion a lot quicker and more interesting.
- Cameron Neylon
Agree -- pre-meeting definitely made the in-person meeting very quick to start off. & @Peter Miller, sent the invite
- Steve Koch
Sounds like a fun (and productive!) day - thanks for sharing it with us, Steve. Also, I would appreciate a Wave invite (if you have any left!) - thanks! tom.tullius@gmail.com
- Tom Tullius
A few comments back, I was simply looking through this filter http://search.creativecommons.org/... with open science - At worst, some really cool Flickr/CC images for future usage for anyone.
- Graham Steel
It occurs to me that in virtually every photo of me online I'm wearing the same jacket and same shirt. Typical academic...
- Cameron Neylon
Went into my garage looking for a textbook. Haven't found it, but found an '87-'88 Slauson Exodus middle school yearbook. Hilarious! Thinking I can probably make some money off this, agreeing not to post certain photos etc. Just to remove myself from the equation, I'm chunky with hair parted down the middle.
Nice photo. It looks like the balloons in the sky are moving whenever I don't directly look at the photo.
- Diego
Now that you mention it, I see that too, Diego. Very cool! KT actually took the photo from her balloon ride with her Dad. Seemed like a great time.
- Steve Koch
Are u kidding me? They Gave You the Nobel Peace Prize? Really? Sorry to ask Mr. President, but Do you even know the definition of the word "Peace" sir? Just Look At Your Face In The Mirror And Ask Yourself how often you Really Think About Other People in other Countries? You Can't even Get Your Troops Out Of Iraq and the whole world is wondering whether you guys are just staying there 4...
more...
- Holy Killer
Especially when you know he is responsible for the murder of Hundreds of My innocent Brothers And Sisters… Just Because You're preoccupied with the Oil in Iran And Fear they might make an atomic bomb one of these days and pass it on to Hamas & Hizbollah to use against Israel doesn't give you the right to remain silent. You know what Mr. President? I Don't Believe in your Audacity of...
more...
- Holy Killer
Totally agree with Holy Killer. now that you have won the prize, you can at least start doin somethin to show you deserve it.... and that somethin better be good Sir ;-) you see... the world needs to be reassured...over and over again!
- Miss Self-Abort
Hey Mr. President! I'm not agree with Holly Killer and the others. Now would you grant me a green card for being nice and supportive? :D
- AutoBioFeeder
حاج مهدی سلام . خوبی شما؟ به انگلیسی از اوباما بپرس جریان اختراع دینامیت رو می دونه یا نه :دی
- وانا
بچه ها ندید بدید بازی در نیارین...حالا فک می کنه رییس جمهور آمریکاست مرتیکه
- MilaD
آن که نامش بود باراک ، هست بی عرضه و با چاک
- وانا
بچهها ببینم میتونیم یه کاری کنیم که جمیعا از اینجا پرتمون کنن بیرون و بلاک حتی :دی خیلی علاقه دارم از جانب یه سیاستمدار برنده جایزه نوبل بلاک شم حتی :دی
- Miss Self-Abort
Interesting that the vast majority of the discussion in this thread concerning an American president's acceptance of the Nobel Peace Prize is in Farsi.
- Maxamad
يعني يه سيخ و منقل هم پيدا نميشه! اينا كه كلي ادعا دارن...! شام هم كه ندارن! حالا نگفتيد باراك چه كاره است؟ تو مايكروسافت كار ميكنه؟ اسمش آشناستها...
- hadi kh
that's cause Iranians are a huge majority on the net Mohomed ;-)
- Miss Self-Abort
Mr President when ever you want to answer me just call me and tell my secretary you won Nobel !he will let you go through my private line!
- phouzhan
Hi Mr President, I am great Iranian political analyst and I want to help you.(One of my works is predicting Iran election that you can find it on my blog). My mother say I one day become a great person and I think that day is come. for more information make comment in my blog. I will contact with you.
- Darieh
میشه دوستام رو هم بیارم؟البته اینا بر میگردن،اما من می مونم،میشل جان خوبن ضمناً؟!بچه هم قد ما هم نداری ازدواج کنیم! می دونی ازدواج یه ارانی تر تبار با یه آمریکایی آفریقایی تبار باعث میشه بچه اینا با هیچ کدوم از این نژاد ها نجنگه!تو فیلم روبان قرمز می گفت به خدا!//جناب مترجم کبابت می کنم اگه سانسور کنی!
- aka "lefthanded"®
بعد اینکه من می دونم این پیام منو پخش نمی کنید! اما ما از مدیران آب و فاضلاب شهرستان هردنبیل آباد می خوایم به آب و فاضلاب اینجا رسیدگی کنن،آسفالت هم نداریم،من هم ی کارم!
- aka "lefthanded"®
all of that comments just kidding,happy times,bye ;)
- aka "lefthanded"®
تجمع اعتراضآمیز به همدستی رژیم اشغالگر نروژ با استکبار جهانی فردا 10 صبح از روبهروی منزل آقای شریعتمداری به سمت دفتر کیهان برگزار میشود
- Darth Farhad Sama
دوستان کارمون تمومه فید اوباما رو خراب می کنید فردا بهمون حمله می کنه اون موقع باید احمدی نژادی بشیم :دی
- hozeh
Don't be shy, step up and support your leader.
- Joe
the majority of Iranians hate A.N. and that's why we don't think President Obama deserved this noble cause he closed his eyes to all recent incidents in here
- Darth Farhad Sama
We didn't close our eyes to anything - only Iranians can change their government - not us.
- Joe
ای ملت رئیس جمهور ندیده :)))) بابا اکانت توییترش را کسی اضافه کرده به فرندفید حالا ملتی به شما می خندند که اینها چقدر جدی گرفته اند
- farzaam
then stop negotiating with our criminal government!
- Darth Farhad Sama
فرهاد جون عالیه...بحثو به جای منم ادامه بده
- blind_owl
Stop complaining and continue to attempt make a change in your own country.
- Joe
@فرزام: چقدرم ملت جدی گرفتن!!! بابا دهن فید رو سرویس کردیم با این مدل کامنت ها!
- علی آقا
Stop looking around for someone else to do what your society needs to do on its own.
- Joe
We're already doing that Joe, risking our lives going to streets and protest in every available event! what else do you expect? start an open war with 100000 fully armed IRGC military force with near 2.500.000 Basiji militia?!
- Darth Farhad Sama
u r in the road that carter was before
- Liquid Soul
Hey joe what's wrong with you? Hah?
- Mr.Chocolate
Thank you PEOPLE of America! but we're not talking about people ! it's your President who is now helping A.N boasting about major political victories and helping our government divert the point of attention away from the Crisis at hand
- Darth Farhad Sama
You are talking about the person we elected to represent us.
- Joe
OK. Obama is so much better that Bush... but the question is: does he really deserve the noble prize?
- علی آقا
The question is : does he deserve all the disrespect people have shown him on this thread?
- Joe
so do we of ours for Mousavi and Karoubi! it's our lives at stake here and your elected president started a peace talk with a criminal and illegitimate dictatorship government!
- Darth Farhad Sama
Obama did nothing to bring the peace to the world? He just talked about the peace... but what happened? are the U.S Troops out of Iraq and Afghanestan now?
- علی آقا
دمت گرم مستر شکلات عزیز...داری با طرف بحث میکنی که نوبل حق کروبی بود:)))
- blind_owl
اي بابا... ولي خودمونيمها، اين جايزه نوبل مسخره تر از اين حرفا شده! حتي حيفه كه به يكي مثل كروبي اين جايزه رو بدن! همين كه به يكي مثل اوباماي تازه كار دادن، خودش حسّابي اين جايزه رو خز كرده!
- hadi kh
یا االله ... یا الله . خانوما چارقدشون رو سر کنن ، حاج آقا جنت مکان اومدن واسه سخنرانی
- وانا
خداييش ديگه اين يارو مترجه "چارقدر" رو نميتونه ترجمه كنه! =))))
- hadi kh
DrHussein you Arzeshi bros are always amazing! although I support Palestine too it doesn't mean you have to kill someone to support another! stop with your 30 years of nonexistence enemy of IRI already!
- Darth Farhad Sama
جناب هادی خ @ دست کم نگیرید این ملت جاسوس را . اینا حتی میدونن برو خونتون کنایه از چیست . مثل ما نیستند که برای علافی فرفرگردی کنند
- راحیل
اوباما جایزه صلح نوبل میگیرد، دقیقا بعد از اینکه تصویب میکنند نیروهای آمریکایی فعلا در عراق و افغانستان بمانند :) / چه جايزهي مسخرهاي، چه جايزهگيرندهي مسخرهتري!
- hadi kh
فحش ناموس هم می شه داد؟ سلام منو به دختر خانوم کلینتون برسونید
- مرحوم محمدمسيح
آلفرد نوبل زمانی که برادرش لودویگ فوت شد، روزنامهها اشتباهاً فکر کردند که نوبل معروف (مخترع دینامیت) مرده است. آلفرد وقتی صبح روزنامه ها را میخواند با دیدن آگهی صفحه اول، میخکوب شد: "آلفرد نوبل، دلال مرگ و مخترع مرگ آور ترین سلاح بشری مرد!" آلفرد، خیلی ناراحت شد. با خود فکر کرد: آیا خوب است که من را پس از مرگ این گونه بشناسند؟ سریع وصیت نامهاش را آورد. جملههای بسیاری را خط زد و...
more...
- hadi kh
It's funny how an Iranian is counting himself among the Americans and referring to them as us....
- Miss Self-Abort
But I also know that this prize reflects the kind of world that those men and women, and all Americans, want to build -- a world that gives life to the promise of our founding documents. And I know that throughout history, the Nobel Peace Prize has not just been used to honor specific achievement; it's also been used as a means to give momentum to a set of causes. And that is why I will accept this award as a call to action -- a call for all nations to confront the common challenges of the 21st century.
- Buddy press
آخه این چه رفتار زشتی بود که با جو داشتین آخه .می خواستم جورش کنم بیاد منو بگیره که دور بعدی بتونم به میس تر پیس -اسپلش:پی آی دابل اس - رای بدم.. نامردا خدا ازتون نگذره!
- Mahsa
ما بازم دیر رسیدم ولی دریافت جایزه نوبل رو به جناب اوباما تبریک عرض میکنم و البته من هم با آقای متکی موافقم! دریافت این جایزه برای آقای اوباما زود بود و بهتر این بود که این جایزه رو به احمدی نژاد می دادن به پاس جنایات و فجایع قبل و بعد انتخابات
- Mohammad Mirzaie
I just like this writing but i do not understand what they mean! cool but atleast i can read and understand f.ahmadinejad, which is funny. hey! visit my site http://www.vinonagroup.com
- VinonaGroupServicesUSA
آقا مبارکه Congratulation Sir فقط but لطفا pls حمایت کن از دموکراسی support democrasi :D:D
- Jan Valjan
Nobel Peace Prize to President Obama - good. Now the goals --- 1. stop Iraq devastating costly colonial occupation war. --- 2. stop Afghanistan occupation war. --- 3. Cut US military budget of $1 trillion to $300 billion a year. http://costofwar.com. China military budget is $60 bill a year .. China has a surplus of $2 trillion, US, by wild capitalism de-investing and industries...
more...
- Petr Buben
"The peculiar demands of our granting system have favoured an upper class of skilled scientists who know how to raise money for a big group... They have mastered a glass bead game that rewards not only quality and honesty, but also salesmanship and networking." I agree with much in this article. Some years back I constructed a list of papers I especially admired, and was surprised to discover that with only a few exceptions they were produced from unfunded research. This was sobering, since it suggest that receiving research grants was (at least according to my judgement of scientific quality) anticorrelated with doing work of the highest quality. Grants seem to be good at sustaining an established area, but not very good at all at producing the conceptual innovations that start new subfields.
- Michael Nielsen
It's very clear that some scientists are just really good at getting money - good salesmen I guess, like you say. They are not always the best scientists yet seem to do well in the jobs market, as universities love scientists who bring in money.
- Sarah Kendrew
"She looked for a job in science publishing or in the granting agencies—both of which, ironically, offer better working conditions and much better security of employment than research."
- Duncan Hull
@Rajarshi Good to see the issues given a higher profile though...
- Duncan Hull
@Duncan, oh absolutely. The idea of long contracts (5 - 7 years) makes sense. But these approaches will really require systemic changes - even if I could get by with small amounts of money (say for 1 student), the university won't like the fact that I'm not bringing in gobs of money to pay for electricity
- Rajarshi Guha
I agree with Duncan that although the situation is depressing (and quite accurately represented in there), seeing it gain higher profile is refreshing.
- Daniel Mietchen
Pushing these issues more and more is vital if we want things to change - even if we don't agree on the solutions, awareness of the problems is a prerequisite for change.
- Björn Brembs
Interesting that similar sentiments have been expressed earlier in engineering. See my write-up Individual and Empire in Academics (on a research article) http://unrulednotebook.wordpress.com/2008...
- Arunn
To be nitpicky, I'm afraid that the following suggestion is as open to abuse and laziness as the current one: "Everyone should get slotted into a funding category and assessed every five years. If you're productive, you get five more years of resources. If productivity is down, you are moved down a category. If it is high, you can apply to move up. Starting PIs are in a different...
more...
- Heather
Hmm. can't write English today. The suggested improvement to the system is subject to abuse, as much so as the current system - dead wood will be carried along. No room will be made for younger people moving up the ranks. And I meant "effective".
- Heather
Lest we forget: http://www.nytimes.com/2008...: "Trained as a biochemist, Dr. Prasher, 57, was interested in the chemistry of how certain animals are able to glow. In the late 1980s, he applied to the National Institutes of Health for a five-year grant to track down the fluorescent protein gene...'I knew it could serve as a genetic marker and it would be really, really useful, which it has turned out to be.' That application was turned down..."
- Richard Klancer
Michael Nielsen wrote above: "Some years back I constructed a list of papers I especially admired, and was surprised to discover that with only a few exceptions they were produced from unfunded research. This was sobering, since it suggest that receiving research grants was (at least according to my judgement of scientific quality) anticorrelated with doing work of the highest quality....
more...
- Bora Zivkovic
I don't have a blog post about it. To make the judgement I used a large fraction of what I know as a scientist. I couldn't easily reduce that to a short list of criteria.
- Michael Nielsen
"It doesn't matter if the book is for lay persons or professionals, the science has to be correct. And saying that all viruses integrate their genomes into that of the cell doesn't help anyone. Dendritic cells take up antigens and particulate matter; their ability to take up entire viruses is a matter of debate and should not be included in a lay book. Exactly what scientists do understand needs to be distilled for everyone but in a correct manner."
- Vincent Racaniello
Great. Now we're going to have the public thinking that flu integrates into the host genome: "help help, the virus is mutating me, aaaaahh!!!".
- Bill Hooker
"Here we examine the development and application of the HapMap to genome-wide association (GWA) studies; present and future technologies for GWA research; current major efforts in GWA studies; successes and limitations of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; use of these findings by clinicians, the public, and academic physicians; and sources of ongoing authoritative information on this rapidly evolving field."
- Attila Csordas
from Bookmarklet
Thanks, Bill. We're really happy that is coming to Kingston. Poor kid will come just before winter, so we hope he stick around for longer, after the first snowstorm :-)
- Paulo Nuin
Way cool!!! So how are you going to react when he opens up Mendeley :)?
- Deepak Singh
Mendeley is currently block in the lab. He will have to prove capable of circumventing our firewall.
- Paulo Nuin
Googling "firewall circumvention for dummies"... ;)
- Ricardo Vidal
Watch your back Paulo, they're trying to get an insider to remove your top search result for "mendeley review" :P Sounds fun. Good luck Ricardo!
- Brian Krueger - LabSpaces
It's a grant typed as catalyst in Canada, focusing on the creation of collaborating teams. On this one we will study bladder cancer and biomarkers. More at http://webapps.cihr-irsc.gc.ca/cfdd...
- Paulo Nuin
Considering one-day workshop on Open Science in the Pacific Northwest in Feb 2010 and asking Science Commons to provide the speakers. There seems little awareness in our region of Open Science Does anyone have contacts at Oregon State University, the University of Washington, etc. and would any of you come?
I'd come, schedule permitting. I have a tenuous connection at OSU and I'm on an advisory board at Pacific U where I could at least spread the word a little. I know someone at OHSU who'd be interested -- I'll email her if she doesn't turn up in this thread.
- Bill Hooker
Thanks, Bill--what a buddy! Pacific University is doing this really neat conference : http://commons.pacificu.edu/sustain... on digital repositories. It would be nice if we could get the quite active software community in the PNW to come and talk to the scientists.
- Hope Leman
I just graduated from OSU, so I know some people in the biochem dept and in the main news office.
- Donnie Berkholz
Hi, Donnie. Thanks so much. I will keep that in mind. There definitely does seem to some interest and Science Commons says it can help provide speakers. I will keep everyone apprised. And way to go on graduating. Dr. Berholz and for starting your postdoc at the Mayo Clinic next month (got that from your Twitter Feed). Sounds like you are an up and comer! Keep up the good work.
- Hope Leman
My wife works at the proteomics resource at UW, and I know folks in the escience group as well
- Deepak Singh
Hi, all. Thank you so much. This is all very reassuring and exciting. Here is background. First of all, Mr. Gunn you are very astute about suggesting that I get in touch with Lisa Green. Interestingly and in fact, she was the one who suggested the idea of a Science Commons event in the PNW. She suggested that I consult Deepak, who responded enthusiastically and helpfully. I also asked...
more...
- Hope Leman
I think it would be a good idea to reach out to as many different sectors as possible. Software is a key element of Open Science, but it's not always clear how commercial software might fit in. F/OSS is a much more intuitive fit. That said, there are companies like Mendeley whose products might find application in Open or closed workflows, and the thing about Open Foo is that people are always thinking of stuff that would never have occurred to me!
- Bill Hooker
I think software also benefits from open data. There are any number of example of open data leading to commercial innovation, so it's not necessarily a bad fit
- Deepak Singh
Hi, guys. Thank you, Deepak and Bill. I appreciate your willingness your tutelage--I blush to admit that I had not heard the term F/OSS before--thanks, Bill. I did a search and came across this useful post: http://www.abhishek-tiwari.com/2009... I am encouraged by what Deepak says and the engineering professor Michael Bailey is leading this innovative project:...
more...
- Hope Leman
Hi, Bill--thank you so much for the link. I found this wording edifying, "Open source is a development methodology; free software is a social movement" and "source-available, or as shared source, a term coined by Microsoft." These are the kinds of issues that could be elucidated at our proposed conference, given that Science Commons (as I understand it) is designed to address such...
more...
- Hope Leman
Hope, Science Commons does not seek to address open source software per se. Creative Commons is all about data and content, which, IMO, is even more important an issue for science.
- Deepak Singh
John Wilbanks put it well I though when he said that his core concern for Science Commons is to enhance interoperability. Any philosophical issues are secondary to ensuring interoperability of code, data, materials, and process. But ensuring that does take us into issues around licensing etc.
- Cameron Neylon
Hi, gentlemen. Thank you for your comments. As I read Deepak's and Cameron's comments, it sounds like there is even more of a need for the proposed conference in that discussion of such issues such licensing etc. could be addressed and elucidated in a manner potentially helpful to scientists (and to librarians, who need to be brought into the discussions more). As I read Deepak, it...
more...
- Hope Leman
I think CC is an essential part of any Open Science conversation. And anything that gets scientists and librarians talking together about Open issues is a Good Thing (TM) in my book.
- Bill Hooker
Hi, Bill--thanks for comment on that. Science Commons Maybe we could have a panel discussion on the various Commons movements: Science, Creative, Neuro and Health. And I agree about the librarian matter. Does anybody have any comment on this sample wording for the proposed conference, "...presents NW Science 2.0 in a one day conference in February 2010. With the help of world class...
more...
- Hope Leman