Maureen

We have over 1100 HCV-Hu ppi in PIG, whereas the authors have far fewer. Not sure why. (PIG aggrepates ppi from public databases like bind and such.) - Timothy Driscoll via Alert Thingy

Roland - That is a good point. I guess one possible test would be to take a similar number of random host proteins (as the pathogen proteins tested) and see how they interact with the other host proteins. This would provide with a random model to test if the pathogen-host interaction properties are significantly different from any random interaction screen. - Pedro Beltrao

The randomization model needs to capture more than just the degree distribution - but I cannot come up with a complete list of how to address the problem as of now. All screens, no matter what is studied connect to proteins with higher degree and than expected. - Roland Krause

this is step 1 of my mission to get more people on here. - Zee from WeDoCreative

Welp. I did what I could. Your excellent post about this great group of people has been shouted to those listening to my "noise". :-) - Mathew A. Koeneker

i need to learn how to hide is part 2 out yet thanks :) - Richard via twhirl

Quote from Kyle Lacy: "This post was amazing!" http://friendfeed.com/e/378ccc... - Ontario Emperor

Nice article, Chris. These are all great ideas to help promote the use of social media throughout business. I think the most important barrier to adoption is the fact that Twitter is a major distraction...IF you allow it to be. However, if you use it at your own pace and under your control it can be quite a useful tool. Cheers, AL - Al Bsharah

All information about erectile dysfunction available here http:///www.starpills.com For more information about weekend pill cialis find you here http://www.impotencehealthcent... If you want to try best ed pill in europe try this site http://www.levitraportal.com - Bill Hamptom

A Mike Fruchter guest blog. - Robert Scoble

Great job Mike! - Corvida

Duude. 67 likes. - Daniel J. Pritchett

Our head of school asked me "are wikis common?" I said it was hard for me to be objective ;-) Assuming that he meant "in an academic life science research setting", what do you think? Do your lab, or labs that you know, routinely use wikis? Are the biologists that you know aware of them? - Neil Saunders

Sure. Our lab wiki is at biowiki.org, and most consortia that I've worked in use wikis (e.g. ENCODE, modENCODE, 12-Drosophila comparative genomics). I don't know what baseline people are using in terms of contributions, but I would say it's considerably easier to get people to edit a wiki than a barebones HTML site. Of course, if wikipedia is your baseline, then all other wikis are abject failures. - Ian Holmes

Isn't defining something as a WIki just saying something is a group project? - sofarsoshawn

If any of you are in the area of Virginia Tech (Blacksburg, VA), do come out. Let me know if you'd like help making arrangements. - Chris Lasher

This inspired me as well, thank you: http://www.enroweb.com/blogsci... - Enro

Also makes a good "one figure" at www.epernicus.com, if you're stuck for ideas - Neil Saunders

I'll ask around. We had someone talk about educational applications of Second Life earlier this year, so it could be an interesting follow-up. - John Dupuis

Matt, I'd be very happy to do that, but for the first run through I'd rather do it live, so I can talk directly with people. If you want to organize something for after that, drop me an email, and I'd love to talk... - Michael Nielsen

Yeah. Sigh. The last strike was 11 weeks. - John Dupuis

Over recent years funding of Systems Biology has increased significantly, with a number of countries also investing in a variety of national initiatives to boost skills in this discipline. Much of the effort, however, is fragmented and lacks standardisation. Delivering a comprehensive, integrated systems biology toolbox that can be applied consistently to the challenges of modern medicine and drug discovery is a complex, “big science” project, comparable to, but more challenging than other major biological endeavours undertaken in the last 20 years. Arguably, if it is ever to reach its full potential and deliver genuine impact, this challenge demands the establishment of a consortium to coordinate effort and establish agreed standards. Views on the feasibility of this proposal and how to it could be achieved are invited. - Maxine

why the hell in Luxembourg I cannot see it??! :-) I can't vote, I know ;) - Luca Conti

I wish people in Luxembourg and all other countries could vote in the US elections today as well ;-) - Bora Zivkovic

Screw that - the USA stands tall against Luxembourg PM Jean-Claude Juncker and his sensible economic policies - Jeremy Leipzig

Will Google have a new logo tomorrow, something about the New Day in America? - Bora Zivkovic

Since it might not be realistic for many people to travel far for this, perhaps we should do regional meetings. Or piggy-back on another conference... - Andrew Su

It would be interesting to try to devise an offline activity that would capture some interest of all 351! - Maxine

Anyone planning to be at ASHG in Philly next week? - Chris Cotsapas

Heck yeah! I haven't managed to write a blog post this week due to personal issues but I'm hoping my multitude of FF posts - including gReader shared notes - will appease a few folks. - Daniel J. Pritchett

It is a great way to "stay involved" on content sharing and voicing opinions when you're super busy, agreed ! - Eric Berlin

I like sharing items this way, plus it generates a lot of interesting email discussions as well - Sally Church

more about gates & risky research projects @ http://www.nature.com/nature/j... - laura

and who can forget Larry Brilliant's brilliant TED talk in 2006:- http://www.ted.com/index.php/t... - Graham Steel

cool, thanks for the TED link! - laura

"DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. In this study, we applied a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in 162 plasma samples from 18 subjects undergoing multimodality therapy for colorectal cancer. We found that ctDNA measurements could be used to reliably monitor tumor dynamics in subjects with cancer who were undergoing surgery or chemotherapy. We suggest that this personalized genetic approach could be generally applied to individuals with other types of cancer." - Attila Csordas via Bookmarklet

Probably I am way behind the times here as I have been out for a couple of days, but here's a post about FF's room search, with a screen shot of the Life Scientists' room as an example of a popular room. - Maxine via Bookmarklet

Oh that's good :) I have been using this sort of thing - http://www.google.co.uk/search... - Jo Brodie

I've been away too, so thanks for posting Maxine, I may have missed it otherwise - Neil Saunders

Yep, it is good - http://friendfeed.com/rooms/se... - and searching for 'diabetes' also brought up this unusually titled room: Zuckerhunde - das sind Hunde mit Diabetes - http://friendfeed.com/rooms/zu.... - Jo Brodie

I'd open a new room, unless the volume will be very low - Michael Kuhn

Sleeping about it, a room will be worthwhile. - Roland Krause

So watch http://friendfeed.com/rooms/re... - Roland Krause

good intro and background video for dinner - Attila Csordas via Bookmarklet

the 3rd guy (Mayfield) is the best presenter - Attila Csordas

"Each block measures 1.5 inches square and depicts six mad science concepts and the appropriate letters. The set includes all 26 letters of the alphabet on five blocks (six illustrations per block). Each side started out as one of our original pen-and-ink drawings that we have carefully laser engraved onto a solid block of American maple wood. We don't use any dyes or harmful finishes on the blocks and all of their edges are rounded and smooth." - Cee Bee via Bookmarklet

A complete list of the images represented by the letters is as follows: A - Appendages B - Bioengineering C - Caffeine D - Dirigible E - Experiment F - Freeze ray G - Goggles H - Henchmen I - Invention J - Jargon K - Potassium L - Laser M - Maniacal N - Nanotechnology O - Organs P - Peasants (with Pitchforks) Q - Quantum physics R - Robot S - Self-experimentation T - Tentacles U - Underground Lair V - Virus W - Wrench X - X-Ray Y - You, the Mad Scientist of Tomorrow Z - Zombies - Cee Bee

"I know some people who always teach their classes the same way, semester after semester, year after year.. Not me. I always want to experiment and try new things. This fall, I'm experimenting with using a wiki in the classroom, in addition to my blog. This wont be my first wiki experience. We've long used wikis where I work, and I've used them to collaborate with people in different locations, but this is the first time that I'll try one in a teaching situation." - Bora Zivkovic