Ambit.js: JavaScript client library for the eNanoMapper API technical preview - http://chem-bla-ics.blogspot.com/2015...
Ambit.js: JavaScript client library for the eNanoMapper API technical preview
Google Code closing down: semanticchemistry and chemojava - http://chem-bla-ics.blogspot.com/2015...
Google Code closing down: semanticchemistry and chemojava
Beyond Beall’s List - http://www.citeulike.org/user...
College & Research Libraries News, Vol. 76, No. 3. (01 March 2015), pp. 132-135 Monica Berger, Jill Cirasella - Egon Willighagen
egonw pushed to master at egonw/pathvisio - https://github.com/egonw...
egonw pushed to master at egonw/pathvisio
Fwd: Dear FriendFeed community, We wanted to let you know that FriendFeed will be shutting down soon. We've been maintaining the service since we joined Facebook five years ago, but the number of people using FriendFeed has been steadily declining and the community is now just a fraction of what it once was. Given this, we've decided that it's...
Thanks for the great platform! It is a shame to see it go :( Of course, the decline is also because people are afraid of advertising it too much, because you stopped development, which is normally a good indication that a service will go down. Effectively, you asked for the decline. This is not so much meant as a complaint, because even in the past years, it served very well as a demonstration of what a social platform should look like. - Egon Willighagen
Isn't it insane that you cannot just look this up? It easier to find that vaccines cause autism than... - https://plus.google.com/1041867...
Isn't it insane that you cannot just look this up? It easier to find that vaccines cause autism than to find basic knowledge like this... sad, so, sad... Time for #openscience ! (If someone has time, please add these shifts to http://nmrshiftdb.org/ !) I recently lamented the lack of experimental nitrogen chemical shifts for small prototypical amides such as formamide, acetamide, and N-methylacetamide. I did some digging and here is what I have came up with so far. Before we get to the amides this very interesting paper show the effects of ... - Egon Willighagen
Ethiopian jawbone may mark dawn of humankind - http://www.citeulike.org/user...
Nature (4 March 2015), doi:10.1038/nature.2015.17039 Ewen Callaway - Egon Willighagen
BioModels: Content, Features, Functionality, and Use - http://www.citeulike.org/user...
CPT Pharmacometrics Syst. Pharmacol., Vol. 4, No. 2. (1 February 2015), pp. 1-14, doi:10.1002/psp4.3 BioModels is a reference repository hosting mathematical models that describe the dynamic interactions of biological components at various scales. The resource provides access to over 1,200 models described in literature and over 140,000 models automatically generated from pathway resources. Most model components are cross-linked with external resources to facilitate interoperability. A large proportion of models are manually curated to ensure reproducibility of simulation results. This tutorial presents BioModels' content, features, functionality, and usage. N Juty, R Ali, M Glont, S Keating, N Rodriguez, MJ Swat, SM Wimalaratne, H Hermjakob, N Le Novère, C Laibe, V Chelliah - Egon Willighagen
Reshared post from Michael Banck: - https://plus.google.com/1041867...
"But you don't sound like a smart boss!" Original Post from Michael Banck: "Coding Like a Girl", some experience (from women) and advise (to men) about femininity in tech, like "If you’re at a conference and talking to a feminine presenting person, assume they are an expert in the field of the conference" and "Before you are about to explain a paper condescendingly to someone in a dress, assume that they wrote it" (via Hanna Wallach) (this was originally given as a talk at AlterConf in Oakland) - Egon Willighagen
The wolf is back in The Netherlands. - https://plus.google.com/1041867...
The wolf is back in The Netherlands. Wolf terug in Nederland | Binnenland | de Volkskrant - Egon Willighagen
egonw pushed to master at egonw/wprdfLoadScripts - https://github.com/egonw...
egonw pushed to master at egonw/wprdfLoadScripts
Homeostasis, Inflammation, and Disease Susceptibility - http://www.citeulike.org/user...
Cell, Vol. 160, No. 5. (8 March 2015), pp. 816-827, doi:10.1016/j.cell.2015.02.010 While modernization has dramatically increased lifespan, it has also witnessed the increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such chronic, acquired diseases result when normal physiologic control goes awry and may thus be viewed as failures of homeostasis. However, while nearly every process in human physiology relies on homeostatic mechanisms for stability, only some have demonstrated vulnerability to dysregulation. Additionally, chronic inflammation is a common accomplice of the diseases of homeostasis, yet the basis for this connection is not fully understood. Here we review the design of homeostatic systems and discuss universal features of control circuits that operate at the cellular, tissue, and organismal levels. We suggest a framework for classification of homeostatic signals that is based on different classes of homeostatic variables they report on.... - Egon Willighagen
Gene regulation. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. - http://www.citeulike.org/user...
Science (New York, N.Y.), Vol. 347, No. 6225. (27 February 2015), pp. 1010-1014, doi:10.1126/science.1259418 Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation. Copyright ©... - Egon Willighagen
egonw commented on commit cdk/cdk@9845964ffd - https://github.com/cdk...
egonw commented on commit cdk/cdk@9845964ffd
The first gene therapy approved in the Western world is set to go on sale in Germany at a cost close to $1 million per treatment. The record-breaking price tag came to light in November 2014, when Amsterdam-based Uniqure and its marketing partner Chiesi, of Parma, Italy, filed a pricing dossier ... - Egon Willighagen
Reshared post from Google Summer of Code: - https://plus.google.com/1041867...
So, NRNB (Cytoscape/WikiPathways/PathVisio) is sadly not part of the GSoC this year :( Original Post from Google Summer of Code: We have 137 mentoring organizations participating in #gsoc2015. Student applications open on 16 March at 19:00 UTC. Will you be applying? Accepted organizations for Google Summer of Code 2015 - Egon Willighagen
egonw commented on issue xmetdb/xmetdb-server#54 - https://github.com/xmetdb...
egonw commented on issue xmetdb/xmetdb-server#54
Prodrugs—from Serendipity to Rational Design - http://www.citeulike.org/user...
Pharmacological Reviews, Vol. 63, No. 3. (01 September 2011), pp. 750-771, doi:10.1124/pr.110.003459 The prodrug concept has been used to improve undesirable properties of drugs since the late 19th century, although it was only at the end of the 1950s that the actual term prodrug was introduced for the first time. Prodrugs are inactive, bioreversible derivatives of active drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or promoiety but instead result from a molecular modification of the prodrug itself, which generates a new active compound. Numerous prodrugs designed to overcome formulation, delivery, and toxicity barriers to drug utilization have reached the... - Egon Willighagen
Activation of nitrofurazone by azoreductases: multiple activities in one enzyme - http://www.citeulike.org/user...
Scientific Reports, Vol. 1 (12 August 2011), doi:10.1038/srep00063 Ali Ryan, Elise Kaplan, Nicola Laurieri, Edward Lowe, Edith Sim - Egon Willighagen
egonw commented on issue xmetdb/xmetdb-server#57 - https://github.com/xmetdb...
egonw commented on issue xmetdb/xmetdb-server#57
egonw opened issue xmetdb/xmetdb-server#57 - https://github.com/xmetdb...
egonw opened issue xmetdb/xmetdb-server#57
egonw reopened issue xmetdb/xmetdb-server#39 - https://github.com/xmetdb...
egonw reopened issue xmetdb/xmetdb-server#39
egonw commented on issue xmetdb/xmetdb-server#39 - https://github.com/xmetdb...
egonw commented on issue xmetdb/xmetdb-server#39
egonw closed issue xmetdb/xmetdb-server#39 - https://github.com/xmetdb...
egonw closed issue xmetdb/xmetdb-server#39
egonw opened issue xmetdb/xmetdb-server#56 - https://github.com/xmetdb...
egonw opened issue xmetdb/xmetdb-server#56
egonw commented on issue xmetdb/xmetdb-server#35 - https://github.com/xmetdb...
egonw commented on issue xmetdb/xmetdb-server#35
egonw opened issue xmetdb/xmetdb-server#55 - https://github.com/xmetdb...
egonw opened issue xmetdb/xmetdb-server#55
Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats - http://www.citeulike.org/user...
Proceedings of the National Academy of Sciences (23 February 2015), doi:10.1073/pnas.1416900112 Even moderate doses of alcohol cause considerable impairment of motor coordination, an effect that substantially involves potentiation of GABAergic activity at δ subunit-containing GABAA receptors (δ-GABAARs). Here, we demonstrate that oxytocin selectively attenuates ethanol-induced motor impairment and ethanol-induced increases in GABAergic activity at δ-GABAARs and that this effect does not involve the oxytocin receptor. Specifically, oxytocin (1 µg i.c.v.) given before ethanol (1.5 g/kg i.p.) attenuated the sedation and ataxia induced by ethanol in the open-field locomotor test, wire-hanging test, and righting-reflex test in male rats. Using two-electrode voltage-clamp electrophysiology in Xenopus oocytes, oxytocin was found to completely block ethanol-enhanced activity at α4β1δ and α4β3δ recombinant GABAARs. Conversely, ethanol had no effect when applied to α4β1 or α4β3 cells,... - Egon Willighagen
The dress (viral phenomenon) - http://en.wikipedia.org/w...
Egonw: Removed trolling. {{Use dmy dates|date=February 2015}} {{Infobox clothing item | title = "The Dress" | image_file = The Dress (viral phenomenon).png | caption = A slightly cropped version of the original, disputed photo of the dress. | designer = Roman Originals<ref name="designer">{{cite web|url=http://www.dailymail.co.uk/news... colors are this dress? White and gold or blue and black? Fierce internet debate is sparked by two-tone outfit - and even Kim and Kanye are divided!|work=[[Daily Mail Online]]|last=Spargo|first=Chris|date=27 February 2015|accessdate=27 February 2015}}</ref> | year = | type = "Lace Bodycon Dress" | material = [[Lace]]<ref name="material">{{cite web|url=http://www.romanoriginals.co.uk/invt... February 2015|title=Lace Detail Bodycon Dress}}</ref> | on_display_at = }} '''The Dress''', also known as '''Dressgate'''<ref name=smh-dressgate>{{cite... - Egon Willighagen
Profiling of volatile organic compounds in exhaled breath as a strategy to find early predictive signatures of asthma in children - http://www.citeulike.org/user...
PloS one, Vol. 9, No. 4. (2014) Agnieszka Smolinska, Ester Klaassen, Jan Dallinga, Kim van de Kant, Quirijn Jobsis, Edwin Moonen, Onno van Schayck, Edward Dompeling, Frederik van Schooten - Egon Willighagen
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