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weerd el jenkofiets ;) - https://plus.google.com/1041867...
weerd el jenkofiets ;) "Weird Al" Yankovic - Word Crimes - Egon Willighagen
Finding the Right Questions: Exploratory Pathway Analysis to Enhance Biological Discovery in Large Datasets - http://www.citeulike.org/user...
PLoS Biol, Vol. 8, No. 8. (31 August 2010), e1000472, doi:10.1371/journal.pbio.1000472 This Essay discusses the role of pathways for exploratory data analysis in present-day biology. Thomas Kelder, Bruce Conklin, Chris Evelo, Alexander Pico - Egon Willighagen
Spatial control of membrane receptor function using ligand nanocalipers - http://www.citeulike.org/user...
Nature Methods (6 July 2014), doi:10.1038/nmeth.3025 Alan Shaw, Vanessa Lundin, Ekaterina Petrova, Ferenc Fördős, Erik Benson, Abdullah Al-Amin, Anna Herland, Andries Blokzijl, Björn Högberg, Ana Teixeira - Egon Willighagen
Synthetisch DNA is handig als biomedische meetlat. Je kunt er mee onderzoeken wat de onderlinge afstand tussen twee functionele groepen moet zijn om op een receptoreiwit te passen, schrijven onderzoekers van het Karolinska-instituut in Stockholm... - Egon Willighagen
Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells - http://www.citeulike.org/user...
J. Am. Chem. Soc. (21 July 2014), doi:10.1021/ja505517t Phenotypic screening provides a means to discover small molecules that perturb cell biological processes. Discerning the proteins and biochemical pathways targeted by screening hits, however, remains technically challenging. We recently described the use of small molecules bearing photoreactive groups and latent affinity handles as fully functionalized probes for integrated phenotypic screening and target identification. The general utility of such probes, or, for that matter, any small-molecule screening library, depends on the scope of their protein interactions in cells, a parameter that remains largely unexplored. Here, we describe the synthesis of an ?60-member fully functionalized probe library, prepared from Ugi-azide condensation reactions to impart structural diversity and introduce diazirine and alkyne functionalities for target capture and enrichment, respectively. In-depth mass spectrometry-based analysis revealed a... - Egon Willighagen
Put Them in Cells and Find Out. In the Pipeline: - http://pipeline.corante.com/archive...
About ligand-protein interactions... - https://plus.google.com/1041867...
About ligand-protein interactions... About this Author. DBL%20Hendrix%20small.png College chemistry, 1983. Derek Lowe The 2002 Model Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . . Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in ... - Egon Willighagen
egonw pushed to master at egonw/cdk - https://github.com/egonw...
egonw pushed to master at egonw/cdk
egonw pushed to master at cdk/cdk - https://github.com/cdk...
egonw pushed to master at cdk/cdk
Hypothesis: The proprietary RDF is valid and uses common ontologies. Start date: 2014-07-23 End date: 2014-07-23. Description: For obvious reasons, this experiment will not disclose all details. It will outline, however, the steps I undertook to do the validation and evaluation. Methods: ... - Egon Willighagen
You’re not allowed bioinformatics anymore | opiniomics - http://biomickwatson.wordpress.com/2014...
"The diverse world of citation indexing services" http://feedly.com/e/cNOyAA9Y - https://plus.google.com/1041867...
"The diverse world of citation indexing services" http://feedly.com/e/cNOyAA9Y When assessing the impact of a published research article, it might seem logical to look at the Impact Factor of the journal that you find it in. But as journals and scholars have moved online, and citation indexing has been automated, the wealth of information for citation discovery and analysis has vastly increased. Citation counts can tell a more accurate story about the scholarly impact that an individual article has made than the journal Imp... - Egon Willighagen
"The diverse world of citation indexing services" http://feedly.com/e/cNOyAA9Y - https://plus.google.com/1041867...
"The diverse world of citation indexing services" http://feedly.com/e/cNOyAA9Y When assessing the impact of a published research article, it might seem logical to look at the Impact Factor of the journal that you find it in. But as journals and scholars have moved online, and citation indexing has been automated, the wealth of information for citation discovery and analysis has vastly increased. Citation counts can tell a more accurate story about the scholarly impact that an individual article has made than the journal Imp... - Egon Willighagen
egonw pushed to master at egonw/cdk - https://github.com/egonw...
egonw pushed to master at egonw/cdk
egonw pushed to master at cdk/cdk - https://github.com/cdk...
egonw pushed to master at cdk/cdk
egonw pushed to master at cdk/cdk - https://github.com/cdk...
egonw pushed to master at cdk/cdk
egonw pushed to master at egonw/cdk - https://github.com/egonw...
egonw pushed to master at egonw/cdk
egonw pushed to master at cdk/cdk - https://github.com/cdk...
egonw pushed to master at cdk/cdk
egonw created tag cdk-1.5.5 at egonw/cdk - https://github.com/egonw...
egonw created tag cdk-1.5.5 at egonw/cdk
egonw created tag cdk-1.5.6 at egonw/cdk - https://github.com/egonw...
egonw created tag cdk-1.5.6 at egonw/cdk
egonw created tag cdk-1.5.7 at egonw/cdk - https://github.com/egonw...
egonw created tag cdk-1.5.7 at egonw/cdk
egonw pushed to master at cdk/cdk - https://github.com/cdk...
egonw pushed to master at cdk/cdk
As introduced in previous posts, SMARTS is a concise notation for describing chemical substructure queries. There are several aspects to a SMARTS implementation: subgraph graph matching, parsing, generating, and even optimisa... - Egon Willighagen
egonw pushed to master at BiGCAT-UM/RPathVisio - https://github.com/BiGCAT-...
egonw pushed to master at BiGCAT-UM/RPathVisio
Drug Discovery Resources Updates. 16 July 2014- Filed In:CytochromeP450 | ADME. I've added two new pages to the ADME section, there are now separate pages for CYP2D6 inhibitors and CY3A4 inhibitors. 22 July 2014 Updated to include CYP2C9 and CYP2C19 inhibitors. Nheterocycles ... - Egon Willighagen
egonw commented on issue benbalter/wordpress-github-sync#25 - https://github.com/benbalt...
egonw commented on issue benbalter/wordpress-github-sync#25
A strategy for grouping of nanomaterials based on key physico-chemical descriptors as a basis for safer-by-design NMs - http://www.citeulike.org/user...
Nano Today (July 2014), doi:10.1016/j.nantod.2014.05.001 Iseult Lynch, Carsten Weiss, Eugenia Valsami-Jones - Egon Willighagen
egonw commented on issue benbalter/wordpress-github-sync#26 - https://github.com/benbalt...
egonw commented on issue benbalter/wordpress-github-sync#26
egonw pushed to master at egonw/wordpress-github-sync - https://github.com/egonw...
egonw pushed to master at egonw/wordpress-github-sync
egonw pushed to master at egonw/wordpress-github-sync - https://github.com/egonw...
egonw pushed to master at egonw/wordpress-github-sync
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