Expert Opin. Drug Metab. Toxicol. In Expert Opinion on Drug Metabolism & Toxicology (12 May 2012), pp. 1-11, doi:10.1517/17425255.2012.685158 Introduction: The development and use of web tools in chemistry has accumulated more than 15 years of history already. Powered by the advances in the Internet technologies, the current generation of web systems are starting to expand into areas, traditional for desktop applications. The web platforms integrate data storage, cheminformatics and data analysis tools. The ease of use and the collaborative potential of the web is compelling, despite the challenges. Areas covered: The topic of this review is a set of recently published web tools that facilitate predictive toxicology model building. The focus is on software platforms, offering web access to chemical structure-based methods, although some of the frameworks could also provide bioinformatics or hybrid data analysis functionalities. A number of historical and current developments are... - Egon Willighagen