Samuli Eldfors

A manual for highly effective thinking - Samuli Eldfors

Managing brain resources in an age of complexity. - Samuli Eldfors

Halcyon Molecular interview - Samuli Eldfors

CSAMA 2011 course materials - Samuli Eldfors

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The census is not static but rather is updated regularly/as needed. In particular we are grateful to Felix Mitelman and his colleagues in providing information on more genes involved in uncommon translocations in leukaemias and lymphomas. Currently, more than 1% of all human genes are implicated via mutation in cancer. Of these, approximately 90% have somatic mutations in cancer, 20% bear germline mutations that predispose to cancer and 10% show both somatic and germline mutations. - Samuli Eldfors

foxl2SNVMix is designed to detect single nucleotide variants from next generation sequencing data. SNVMix is a post-alignment tool. Given a pileup file (either Maq or Samtools format) as input and model parameters, SNVMix will output the probability that each position is one of three genotypes: aa (homozygous for the reference allele, where the reference is the genome the reads were aligned to), ab (heterozygous) and bb (homozygous for a non-reference allele). A tool for fitting the model using expectation maximization is also supplied (use -T option). - Samuli Eldfors

Approved Drug Products with Therapeutic Equivalence Evaluations - Samuli Eldfors

variant annotation - Samuli Eldfors

variant annotation - Samuli Eldfors

Bioinformatics blog by Oliver Hofmann - Samuli Eldfors

Bioinformatics blog by Oliver Hofmann - Samuli Eldfors

SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations. - Samuli Eldfors

SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations. - Samuli Eldfors

Variant calling, somatic/germline variant filtering - Samuli Eldfors