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Donnie Berkholz › Likes

Mickey Kosloff
My paper is *finally* online in Nature Structural & Molecular Biology: "Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions" - http://www.nature.com/nsmb...
My paper is *finally* online in Nature Structural & Molecular Biology: "Integrating energy calculations with functional assays to decipher the specificity of G protein–RGS protein interactions"
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Iddo Friedberg
A closer look at the first PacBio sequence dataset - http://oelemento.wordpress.com/2011...
Lovely to see this kind of analysis. - Cameron Neylon
Mickey Kosloff
Productivity shortfalls in drug discovery: Contributions from qualititative, consensus- dependent, technology-driven preclinical science? — JPET - http://jpet.aspetjournals.org/content...
Björn Brembs
"In the best of all possible worlds, what you would like is for all papers to be published, just making sure that the conclusions are reasonable given the observations. And then retrospectively assess the impact and importance of the paper." - Björn Brembs from Bookmarklet
pq: "Your instinct when you’re starting out is to be defensive and protect what you have. You’ve made a reagent, you’ve made a mouse, you’ve had an idea that somebody else could jump on and run with very quickly if they knew about it. So your tendency is to keep things to yourself rather than sharing. But it turns out that’s the wrong choice almost every time. You really benefit from... more... - Björn Brembs
still leaves open the question of what productivity is, but i like the spirit of this: "It makes little sense to judge a grant mainly on the basis of the project. Because most of the time, the project isn’t going to get done the way it’s outlined in the grant. If you knew exactly what you’d be doing three to five years from now, you probably shouldn’t be doing it. Because the results of... more... - Mickey Schafer
I was just thinking about this today from another perspective. How many people waste their time (=wasting money too) doing redundant things and not finding out about it except when it's too late. It's time for collaborative or dossier-like articles that publish scientific results, observations, and "knols" not just news and reviews - Ramy Karam Aziz
What fascinates me about all of these articles is that they are a dime a dozen: there have been so many people speaking out on so many issues and not no-names by any stretch. These articles, editorials, etc. all agree more or less, on what is wrong, whose fault it is and what needs to change. Yet, very little is happening. Are things moving at the pace they physically can, or are people just not enraged enough for serious reform? - Björn Brembs
That may be true for a fraction of scientists, I don't know the size of that fraction, though. In my experience, many senior scientists are well aware of what should change and how absurd in many instances our current way of doing science is. Maybe much of the inertia comers from "what could I change?" - Björn Brembs
Michael Kuhn
Nice review on what we have learned and what there is to learn from all those genomes http://dx.doi.org/10...
Mr. Gunn
Genome Biology | Full text | When the pie is too small - http://genomebiology.com/2010...
pq: "By the way, $32 billion is exactly the sum that BP has been forced to pay by the US government as a penalty for the Gulf of Mexico oil spill. I don't know whether to laugh at that coincidence or just cry. " - Bill Hooker
Crying is an acceptable response. So is screaming into the night sky. What else can you do? - Mr. Gunn
Antony Williams
American Chemical Society Announcement on Leadscope Decision: QUOTE "The amount of the judgment, which includes certain attorneys’ fees and interest, approximates $40 million. Should satisfaction of the judgment become necessary, ACS does not anticipate that it will result in changes to staff, ongoing programs, or member dues."...
Hadn't heard this story before. What a thrilling tale of ACS attacking the little guys. - Donnie Berkholz
The whole ruling is here: http://www.leagle.com/unsecur... -- pretty interesting reading. - Donnie Berkholz
...but the ACS is a non-profit. The $40M must come from somewhere. I'm a member of the ACS. I had never heard of this trial. - Matthew Todd
Charities, not for profits etc can still get engaged in law suits and the associated costs come from the coffers that would generally be applied to other things. This case has being going on for a number of years and in theory is over but may get challenged again. - Antony Williams
Chris Miller
Nature Genetics talks up Analysis articles which "report primary research carried out on publications, datasets or research practices." http://www.nature.com/ng...
"Reanalysis is a direct measure of utility to other researchers, which is the basis for reputation and for a high level of citation. So there is potentially value in Analyses looking at the accessibility of data, the adequacy of metadata and protocols, and the reproducibility of specific results. Such studies—if transparently and responsibly conducted—can be more useful in guiding excellent research practices than any number of standard-setting documents because they directly demonstrate the effects of data formatting, accessibility and precisely described decision making on other researchers' ability to use the published results and data." - Chris Miller
Nature wakes up to bioinformatics, sorry Bioinformatics. - Greg Tyrelle
I'm as confused as the rest of you, but I thought it was notable for acknowledging the role of research that doesn't fit the standard Nature mold. - Chris Miller
Nature biotech and Nature Struc and Mol Biology also have this "analysis" category. Cell also came out with a "theory" section not that long ago. I don't like the fact that it is labeled but I sure like to have more journals with such a wide audience allowing submissions of computational work. - Pedro Beltrao
Prior to this label, I wasn't aware that Nature Genetics would think this work within its scope. - Heather Piwowar
Chris Miller
Ruchira S. Datta
SATCHMO-JS: a webserver for simultaneous protein multiple sequence alignment and phylogenetic tree construction http://nar.oxfordjournals.org/cgi...
Congrats! I have a question about your alignment -- how come you didn't compare it to the best stuff out there, like ProbCons/ProbAlign? Was it the tradeoff between accuracy and speed? - Donnie Berkholz
Nevermind, I just got to the Future Work section. =) - Donnie Berkholz
Donnie, thanks for your interest. In fact, the accuracy of SATCHMO-JS is competitive with ProbCons in accuracy, while taking much less time. These results are not yet published (we've submitted them). - Ruchira S. Datta
Could the server source code be made available? Looks like a great utility. - Mike Chelen
Mike, thanks for your interest. We do plan to make SATCHMO-JS available as downloadable software--we have a very small group, though, so it's taking some time. - Ruchira S. Datta
That is great to hear! Open source makes the software more accessible for both implementation and learning by examination. What are the challenges in releasing the code? Knowing that the group intends to do so makes waiting patiently much easier :) - Mike Chelen
There are just a lot of pieces to the pipeline. We need to extract it and package it up. - Ruchira S. Datta
Rajarshi Guha
Tripod Development » Blog Archive » Automated R-group analysis - http://tripod.nih.gov/?p=46
Now available to play with - Rajarshi Guha from Bookmarklet
Mickey Kosloff
Byte Size Biology » Open Access: what’s in it for me? - http://bytesizebio.net/index...
"One problem that I am facing is convincing colleagues of the utility of an Open Access publication. ... Not everyone operates on large grants. Many lab budgets leave very little room to buy a new laptop, let alone pay for an OA publication (typically the price of two of said laptops)." - Mickey Kosloff from Bookmarklet
Good points here. Proving a rival to current closed-access or setting a precedent to get grant-givers to make line-items for OA publication are good in an abstract/aggregate level, but the individual lab decision-maker is thinking on a lot more concrete terms. Perhaps, some sort of Impact Factor or "open access journal news" to add credence/credibility can substitute? - Benjamin Tseng
I'm glad you've made the point -- I talk about it with students who will have to make these kinds of decisions in the coming years -- and it's a tough one: ideological belief against practical action. Maybe we need a kind of OA investment account where interest can be accrued over the life of a grant. Okay, not realistic...government subsidies, maybe;-)? - Mickey Schafer
Deepak Singh
Zachary Voase’s Blog — Bioinformatics and the Semantic Web - http://blog.zacharyvoase.com/post...
Also check out his other post: http://blog.zacharyvoase.com/post... Awesome awesome stuff. Also, I'm more than a little relieved to find out I'm not crazy. Or at least that I have company in crazy town depending on the interpretation. - Paul J. Davis
Nice post, but I don't think it would sell me on using RDF. It's not like you can't agree on syntax and meaning (or even use ontologies) without RDF. Better to show how RDF helps deal with the fact that not all databases are ever going to agree on a single set of non-overlapping concepts for describing their data, and -- more important -- with more fundamental disagreements (such as what an organism even is). - Eric Jain
Björn Brembs
This is absurd! Since when was the methods section in "Nature Methods" papers in a supplement?
"like" as in "wtf?" - Bill Hooker
Since they started confusing houseflies with drosophila? http://www.michaeleisen.org/blog... - Marcos de Carvalho
Nature Methods - methods = ? Is this process iterative? - Richard Badge from Nambu
Perhaps that's their undercover advocacy for Open Access to the methods sections? - Daniel Mietchen
Iddo Friedberg
Byte Size Biology » Finally: a Nobel prize for the ribosome structure - http://bytesizebio.net/index...
Yes! Finally!!! - Alejandro Montenegro
"The acid test: if I see electrons pushed around, it's chemistry" http://scienceblogs.com/terrasi... - Iddo Friedberg
I really want to "like" that comment, but I guess I'll settle with the whole post... - Donnie Berkholz
Wladimir Labeikovsky
I’m reviewing the situation - Reciprocal Space - Stephen Curry's blog on Nature Network - http://network.nature.com/people...
Imo journals should simply refuse to publish without full M&M details, sufficient for replication. - Bill Hooker
I agree, Bill. Why even show the data at all if no one can replicate it? - Mr. Gunn
More emphatically, my opinion is that it's not science if it's irreproduceable (even if that's through poor documentation). - Donnie Berkholz
My comment is at the post - what Nature would have done under these circumstances. - Maxine
One more reason to go open science - if you keep your notebook online, it should be much easier to find the missing information. Alas, I also struggled quite a while with such an old omission and will probably blog about that soon (after finally contacting my "Carters" who were also the main competitors at the time). In my case, the "Chinese" group was Japanese and finally posted an... more... - Daniel Mietchen
Update: My "Carters" reacted friendly to my friendly inquiry, and we provided each other with more details on the experiments, but it is still next to impossible to reconcile our results, and neither they nor me currently have funds for this line of research - another case where baseline grants would be handy. - Daniel Mietchen
Abhishek Tiwari
Bring Back Reprint Requests :The Scientist [2009-09-01] - http://www.the-scientist.com/article...
"The Internet has changed scientific publishing in many ways, some good and some bad. No one would deny that it is easier to find papers on a particular subject than ever before. Looking up papers in Index Medicus or by browsing Current Contents has long been replaced by online searches on Medline or even Google Scholar. This has not necessarily improved our understanding of the literature, but it certainly provides a quick way to feel up to date." - Abhishek Tiwari from Bookmarklet
quick way to get rid of this pang of nostalgia: file and send the reprints yourself, don't have your secretary do it - Wladimir Labeikovsky
on the other hand. maybe torrents of emails asking for pdfs will motivate the PI's that remain apathetic towards open access - Wladimir Labeikovsky
I agree that the ability to track readership and download stats for my papers would be *extremely* valuable. It will probably just become more so as online papers approach the next-gen prototypes so you could even tell which sections and figures are viewed most. - Donnie Berkholz
Michael Kuhn
Cool study: if you get lost, you will walk in circles. http://www.cell.com/current...
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the researches had people get lost in a German forest, and in the freaking SAHARA. If you do that, then you might as well put your research in an Open Access journal. - Michael Kuhn
(Tautological) Fact of the day: "Sahara desert" in the abstract means "Deserts desert" as Sahara means deserts in arabic. - Michael Barton
@Michael: I guess you've seen the list on Wikipedia: http://en.wikipedia.org/wiki... - Michael Kuhn
Heather
Liked: The majority of papers published online in The EMBO Journal now contain in their supplementary material section a Review Process File including referee reports and author responses. We also continue to encourage citing of primary literature through allowing unlimited references. (www.embojournal.org)
It's nice to see other journals following the system Biology Direct has. - Alejandro Montenegro
Transparency has to be good... - Peter Murray
"The majority of papers published" - why not all? - AJCann
Berci Mesko, MD
This is really good! - Björn Brembs
absolutely terrific! And funny in places as well, which doesn't hurt one bit :) - 'Mummi' Thorisson
Great and so comprehensive. Will interest many of us - novoseek
excellent b/c addresses delivery and environment as well as design -- most instructional sites don't do this, though Michael Alley on posters (http://www.writing.engr.psu.edu/posters...) and especially power point presentations (http://www.writing.engr.psu.edu/slides...) are generally excellent, student-friendly guides -- not necessarily humorous, unless you like squirrels. - Mickey Schafer
Abhishek Tiwari
What If Scientists Didn’t Compete? - TierneyLab Blog - NYTimes.com - http://tierneylab.blogs.nytimes.com/2009...
"What if scientists, instead of rushing to publish or perish, chose to cooperate? Sean Cutler decided to do “a little experiment,” as he calls it, and you can see the results in the forthcoming issue of Science. " - Abhishek Tiwari from Bookmarklet
Wish I could 'Like' twice - Andrew Clegg
If you divide the impact factor of the publication by the number of authors, then you might find out that the outcome of the sum of efforts is less than the sum of independent publications would be. After all, the amount of data obtained by these people does not depend on whether it is published in a single article in Science or several articles in more specialized journals. In fact,... more... - genereg
This is part of how the Gates foundation is trying to accelerate research, by tweaking the incentives so scientists cooperate. I find one of the Tierney article statements misleading: scientists are ultimately competing for funding, not ego. - Wladimir Labeikovsky
"scientists are ultimately competing for funding, not ego" -- I completely agree with this. in many cases, scientists also "cooperate" just to get better funding, not to make better science. - genereg
natural curiosity could provide sufficient energy to drive science without necessity of competition. but for that kind of thing to function academia might need "unlimited" resources...or a more even resource distribution.. - Yaroslav Nikolaev
"...or a more even resource distribution..." - like it was in the Soviet Union or China. Means the end of the current US grant system. - genereg
sharing data with competitors, an interesting concept - science article http://dx.doi.org/10... and summary http://tinyurl.com/cl688w - joergkurtwegner
I don't think cooperation and competition are exclusive. And both can lead to waste if taken too far... - Eric Jain
+1 Eric. Balance is key (and right now I think the balance is tilted way too far towards competition). - Bill Hooker
cooperation and competition go hand in hand. although opposing teams in a soccer match may be competing, they have a mutual pact the goal of which is to have each team play their best. - Mike Chelen
Mike, football teams aren't trying to build a reliable body of knowledge. I don't think the analogy holds up. :-) - Bill Hooker
Bill, they are trying do the best in their field (hehe), isn't the same true for scientists? - Mike Chelen
By determining goals, method of achievement, and providing feedback competition can be designed to encourage cooperation. - Mike Chelen
Jan Aerts
bashreduce - mapreduce in a shell script - http://github.com/erikfre...
Obviously sorting isn't the most parallizable test, but sorting on a dual-core machine took nearly twice as long with bashreduce. I probably should test some quad or 8-core machines before passing judgement. - Chris Miller
Abhishek Tiwari
"What you're doing is very clever, and I see how it's useful, but how is it science?" - Abhishek Tiwari
"It's not. How is your research science?" - Abhishek Tiwari
Bora Zivkovic
They don't make it very easy to send a copy online. - Donnie Berkholz
Bother your US friends? - Bora Zivkovic
Andrew Su
NIH funding in the stimulus package - http://www.nytimes.com/2009...
"The usual N.I.H. research grant is from $250,000 and $300,000 and runs for four years, and each grant supports six or seven full-time or part-time jobs, Dr. Kington said. To provide a quicker economic impact, the institutes may also award two-year grants of $500,000 per year, but soliciting proposals and judging them could take up to a year." - Andrew Su
Jason Stajich
From Beth Weil, head librarian at UCB "Berkeley's Research Impact Initiative turns one year old today. So far we are very pleased with the results. We have received 40 requests for funding, indicating that there is interest and a need for funding of open access journal articles.
There is more good news for UC journal authors. The California Digital Library (CDL) and Springer have signed a ground-breaking agreement in which UC-authored articles accepted for publication in most of the 1700 Springer journals will be published using Springer "Open Choice" which brings with it full and immediate access to all readers. This means that UC authors will pay no additional publication fees in order for their articles to be immediately and fully open to all. Under the agreement, articles will be published under a license in which authors retain the right to distribute and re-use their articles freely. - Jason Stajich
To invoke the "Open Choice" option, UC authors will select a UC campus affiliation from a drop-down box that appears on the acceptance screen which authors must complete once an article has been accepted for publication. A message on the acceptance screen will indicate that the Open Choice option is being made available to them at no charge. (The Open Choice publication fee would... more... - Jason Stajich
Michael Habib
Elsevier Launches SciTopics—Now a Fully Developed Research 2.0 Resource - http://newsbreaks.infotoday.com/nbReade...
Do any of you use SciTopics? - Steve Koch
Alexey
Bench Marks » Blog Archive » Information overload is NOT filture failure - http://www.cshblogs.org/cshprot...
"Now, most scientists are familiar with the “cataloging system” of scientific journals, they’ve been reading them their entire careers. Everyone has their own filters, their own rankings of which journals are more interesting, or publish better work than others. And all kinds of tools are available for filtering things down to just the relevant essentials for keeping up with your own field. But even so, most people that I talk to are left with more useful, relevant articles that they need to read than they have time to get to. These are not articles that should be filtered out. These are important, quality findings of direct relevance to their own work. And there are too many of them without even factoring in a need to keep up with science in general and see what developments in other fields can be applied to one’s own." - Alexey from Bookmarklet
Maxine
Science by litigation : Article : Nature - http://www.nature.com/nature...
"A company's lawsuit against researchers should not be allowed to intimidate others." Note: free to access online (registration may be required). - Maxine from Bookmarklet
Melanie Baker
dave: Judge rules Ohio homeless voters may list park benches as addresses. http://bit.ly/JdoMe - http://identi.ca/notice/949211
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