First, I want to say I found this nice prednisone pill blog online ... Rheumatoid arthritis treatment patients with severe morning stiffness appeared to benefit more from a prednisone formulation that delivered the drug while they slept than from taking the same dose on awakening, researchers found. Action Points * Explain to patients who ask that a delayed-release formulation of prednisone when taken at bedtime was more effective for reducing joint stiffness than a same-dose standard pill taken in the morning. * Note that the formulation is still investigational. In a phase 3 study, the mean relative change in the duration of morning stiffness over 12 weeks improved by about 22% with the modified-release prednisone (Lodotra) versus the standard formulation, Frank Buttgereit, M.D., of Charité University Medicine here, and colleagues, reported in the Jan. 19 issue of The Lancet. Although glucocorticoids still have substantial risks, they are essential for successful treatment of some... - Bree Olson