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What's Next: Dispatches on the Future of Science (Vintage) - http://www.amazon.com/dp...
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Open Science: a step towards Open Innovation - http://freelancingscience.com/2009...
Anders Norgaard, Michael Nielsen, Jim Hardy and 10 other people liked this
Pawel. I don't feel as pessimistic as you do - I don't feel convinced that Open Source approaches are incompatible with drug discovery. But I do think that Open Science is incompatible with intellectual property preservation (unless used as an offensive ploy to invalidate a competitor's patent application). Innocentive is a good example of crowdsourcing but not of Open Innovation - if...
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- Jean-Claude Bradley
Jean-Claude, probably it's not really an incompatibility, but a competitive (or even legal) disadvantage of certain "open" approaches. After all, pharmaceutical companies have a legal obligation to increase shareholders value, not to solve world's health problems. Hence the need of three domains (Science, Politics and Business) for OS to become mandatory. And I'm not really pessimistic...
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- Pawel Szczesny
Pawel - because of their business model I can't see that the typical pharmaceutical company can do much Open Science. Anything they wish to protect by US patent would have to be submitted by the provisional patent mechanism on a daily basis which is impractical and certainly an unnecessary cost. But I do see that some small non IP critical data could be shared to everyone's benefit - for example solubility data on starting materials that all chemists could use.
- Jean-Claude Bradley
Jean-Claude, even Heller (of "The Gridlock Economy") argues that getting rid of IP preservation is going to be extremely difficult for various (reasonably sounding) reasons, so I can't see pharma adopting OS as well. But not all research actually has a commercial value, so I hope that mandatory OS (in academia?) will not do that much harm. On the other hand, grant agencies (at least...
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- Pawel Szczesny
There is clearly a close coupling between the (short to medium) term success of business models and the environment they operate in, but I wonder whether in the long term only business models that actually add value can win, and that they will actually drive environmental change. There must be analogous arguments in evolution/ecology about coupling between environment and species success presumably?
- Cameron Neylon
p.s. great post
- Cameron Neylon
I think this is a step in the right direction. White House proposes 7-year protection for brand-name biotech drugs White House officials sent a letter to Rep. Henry Waxman, D-Calif., recommending that brand-name biotech drugs be given seven years of intellectual property protection before generic versions can be launched, saying it "strikes the appropriate balance between innovation and...
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- Jim Hardy
Funding bodies and publishers have the ability to make some form of OS mandatory but I don't see that happening in the short term. My bet is that change will happen by scientists doing so voluntarily - mainly for selfish reasons. With more people doing OS the general pressure in the scientific community to not hoard data will increase. Still I don't think it is likely or even desirable...
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- Jean-Claude Bradley
From the Vault - The FriendFeed Attitude - Expression Patterns - Eva Amsen's blog on Nature Network - http://network.nature.com/people...
I should post it under "self-love" or NPD.
- Pawel Szczesny
point to consider: "I was finally able to find out how to delete my account. And when I did, all the posts and comments I had ever left anywhere on FriendFeed disappeared with me. Including the notes I took at conferences."
- Daniel Mietchen
Origin of Wealth: Evolution, Complexity, and the Radical Remaking of Economics - http://www.amazon.com/dp...
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Miss Vu*, Michael Nielsen and Sung W. Lim liked this
A synthetic genetic edge detection program. - http://www.ncbi.nlm.nih.gov/entrez...
Peter Miller, Jean-Claude Bradley and Rajarshi Guha liked this
"Edge detection is a signal processing algorithm common in artificial intelligence and image recognition programs. We have constructed a genetically encoded edge detection algorithm that programs an isogenic community of E. coli to sense an image of light, communicate to identify the light-dark edges, and visually present the result of the computation. The algorithm is implemented using multiple genetic circuits. An engineered light sensor enables cells to distinguish between light and dark regions. In the dark, cells produce a diffusible chemical signal that diffuses into light regions. Genetic logic gates are used so that only cells that sense light and the diffusible signal produce a positive output. A mathematical model constructed from first principles and parameterized with experimental measurements of the component circuits predicts the performance of the complete program. Quantitatively accurate models will facilitate the engineering of more complex biological behaviors and inform bottom-up studies of natural genetic regulatory networks."
- Pawel Szczesny
cool
- Jean-Claude Bradley
Complex human chromosomal and genomic rearrangements. - http://www.ncbi.nlm.nih.gov/entrez...
Compelling reasons why viruses are relevant for the origin of cells. - http://www.ncbi.nlm.nih.gov/entrez...
Modular model-based design for heterologous bioproduction in bacteria. - http://www.ncbi.nlm.nih.gov/entrez...
Engineering algae for biohydrogen and biofuel production. - http://www.ncbi.nlm.nih.gov/entrez...
MemeTracker: tracking news phrases over the web - http://www.memetracker.org/
MemeTracker builds maps of the daily news cycle by analyzing around 900,000 news stories and blog posts per day from 1 million online sources, ranging from mass media to personal blogs.
- Pawel Szczesny
Degrafa : Declarative Graphics Framework - http://www.degrafa.org/
Pierre liked this
Degrafa is an open source declarative graphics framework.
- Pawel Szczesny
Gephi, graph exploration and manipulation software - http://gephi.org/
Pierre liked this
Gephi is an open-source software for visualizing and analyzing large networks graphs. Gephi uses a 3D render engine to display graphs in real-time and speed up the exploration.
- Pawel Szczesny
jQuery Sparklines - http://omnipotent.net/jquery...
Euan liked this
This jQuery plugin generates sparklines (small inline charts) directly in the browser using data supplied either inline in the HTML, or via javascript.
- Pawel Szczesny
XML/SWF Charts > Introduction - http://www.maani.us/xml_cha...
Ricardo Vidal and Pierre liked this
XML/SWF Charts is a simple, yet powerful tool to create attractive charts and graphs from XML data.
- Pawel Szczesny
Science 2.0 group (http://friendfeed.com/science... ) is growing very fast - it has already over 500 subscribers, which is probably the second largest group I am subscribed to. For comparison, The Life Scientists room is approaching 1000 subscribers, but I think it's significantly older.
Michael Nielsen and Pierre liked this
but how many 'active' members in both groups ?
- Pierre
I don't know yet - let me check.
- Pawel Szczesny
Correction, I will try to do it tomorrow. My institutional network has died and I've lost access to any machine with perl :/.
- Pawel Szczesny
All 2.0 – an attempt to connect disciplines - http://freelancingscience.com/2009...
Michael Habib, Pierre, Matt Leifer and 4 other people liked this
Corrected a bug that caused wrong sorting by date on some columns (mostly due to inconsistencies between encoding date in various RSS formats). Now, all FF & Twine entries are properly sorted.
- Pawel Szczesny
Visual analysis in not only about seeing - http://freelancingscience.com/2009...
Dynamics of transposable elements: towards a community ecology of the genome. - http://www.ncbi.nlm.nih.gov/entrez...
Regulome size in Prokaryotes: universality and lineage-specific variations. - http://www.ncbi.nlm.nih.gov/entrez...
Ten Simple Rules for Choosing between Industry and Academia - http://www.ploscompbiol.org/article...
Daniel Mietchen and Jan Aerts liked this
[METHODS AND RESOURCES] mGene: Accurate SVM-based gene finding with an application to nematode genomes - http://genome.cshlp.org/cgi...
Parallel Sets | EagerEyes.org - http://eagereyes.org/paralle...
Parallel Sets (ParSets) is a visualization application for categorical data, like census and survey data, inventory, and many other kinds of data that can be summed up in a cross-tabulation. ParSets provide a simple, interactive way to explore and analyze such data.
- Pawel Szczesny
HackerspaceWiki - http://hackerspaces.org/wiki...
Hackerspaces are community-operated physical places, where people can meet and work on their projects.
- Pawel Szczesny
Physical coworking space for technology geeks. Where are these for science geeks? :)
- Pawel Szczesny
Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex. - http://www.ncbi.nlm.nih.gov/entrez...
Presentation rights - http://www.flickr.com/photos...
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Graham Steel liked this
Excellent
- Graham Steel
IMG ER: A System for Microbial Genome Annotation Expert Review and Curation - http://bioinformatics.oxfordjournals.org/cgi...
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Piotr Byzia and Bill Hooker liked this
ISO up to 25600 and F1.4 lens - absolute joy of handholding a camera in night photography :).
- Pawel Szczesny
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