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Gene Genie

Gene Genie

The microcarnival of human genes and personalized genetics.
Blog
Amira
Scientists recreate evolution of complexity using ‘molecular time travel’ - http://aminotes.tumblr.com/post...
Scientists recreate evolution of complexity using ‘molecular time travel’
“Much of what living cells do is carried out by “molecular machines” – physical complexes of specialized proteins working together to carry out some biological function. (…) In a study published early online on January 8, in Nature, a team of scientists from the University of Chicago and the University of Oregon demonstrate how just a few small, high-probability mutations increased the complexity of a molecular machine more than 800 million years ago. By biochemically resurrecting ancient genes and testing their functions in modern organisms, the researchers showed that a new component was incorporated into the machine due to selective losses of function rather than the sudden appearance of new capabilities. (...) The increase in complexity was due to complementary loss of ancestral functions rather than gaining new ones. (...) “It’s counterintuitive but simple: complexity increased because protein functions were lost, not gained,” Thornton said. “Just as in society, complexity... more... - Amira from Bookmarklet
"The accumulation of simple, degenerative changes over long periods of times could have created many of the complex molecular machines present in organisms today. Such a mechanism argues against the intelligent design concept of “irreducible complexity,” the claim that molecular machines are too complicated to have formed stepwise through evolution. (...) “These really aren’t like... more... - Amira
Amira
The Genographic Project ☞ A Landmark Study of the Human Journey (Migration, Population, Genetics) | National Geographic - http://aminotes.tumblr.com/post...
The Genographic Project ☞ A Landmark Study of the Human Journey (Migration, Population, Genetics) | National Geographic
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"Where do you really come from? And how did you get to where you live today? DNA studies suggest that all humans today descend from a group of African ancestors who—about 60,000 years ago—began a remarkable journey. The Genographic Project is seeking to chart new knowledge about the migratory history of the human species by using sophisticated laboratory and computer analysis of DNA contributed by hundreds of thousands of people from around the world. In this unprecedented and of real-time research effort, the Genographic Project is closing the gaps of what science knows today about humankind's ancient migration stories." - Amira from Bookmarklet
See also: Evolution of Language tested with genetic analysis http://ff.im/Bd8em - Amira
Amira
Early humans' route out of Africa 'confirmed' (A six-year effort to map the genetic patterns of humankind) - http://www.bbc.co.uk/news...
Early humans' route out of Africa 'confirmed' (A six-year effort to  map the genetic patterns of humankind)
"A six-year effort to map the genetic patterns of humankind appears to confirm that early people first left Africa by crossing into Arabia. Ancestors of modern people in Europe, Asia and Oceania migrated along a southern route, not a northern route through Egypt as some had supposed. (...) It suggests an important role for South Asia in the peopling of the world. The ancestors of present-day non-African people left their ancestral homeland some 70,000 years ago. The researchers found that Indian populations had more genetic diversity - which gives an indication of the age of a population - than either Europeans or East Asians. This supports the idea that pioneering settlers followed a southern coastal route as they populated east Asia and continued into Oceania. (...)" - Amira from Bookmarklet
"A route out of Africa via the Arabian Peninsula, along the southern coast of Asia, explained the observed patterns in genetic diversity much better than a route through Egypt's Sinai desert. This agrees with other evidence showing that sea levels might have been low enough around 60-70,000 years ago for humans to cross from the horn of Africa into Arabia (...) The latest findings are... more... - Amira
Berci Mesko, MD
Scripps launches whole genome sequencing study to find root causes of idiopathic diseases - http://medicalxpress.com/news...
Berci Mesko, MD
Illumina Reports Drop in Preliminary Q3 Revenues | GenomeWeb Daily News - http://www.genomeweb.com/illumin...
Berci Mesko, MD
The Future Is Now: 23andMe Now Offers All Your Genes For $999 (will be even cheaper) - http://www.forbes.com/sites...
Amira
Human Nature. Sapolsky, Maté, Wilkinson, Gilligan, discuss on human behavior and the nature vs. nurture debate (video) http://aminotes.tumblr.com/post...
Sapolsky.jpg
“Nothing is genetically programmed. (...) An epigenetic effect. “Epi” means on top of, so that the epigenetic influence is what happens environmentally to either activate or deactivate certain genes. (…) Life experiences that not only shape the person’s personality and psychological needs but also their very brains in certain ways. And that process begins in utero. (...) The great British child psychiatrist, D.W. Winnicott, said that fundamentally, two things can go wrong in childhood. One is when things happen that shouldn’t happen and then things that should happen but don’t. (…) “Interpersonal Neurobiology” which means to say that the way that our nervous system functions depends very much on our personal relationships, in the first place with the parenting caregivers, and in the second place with other important attachment figures in our lives and in the third-place, with our entire culture. (...) " - Amira
"On a certain level the nature of our nature is not to be particularly constrained by our nature. We come up with more social variability than any species out there. More systems of belief, of styles, of family structures, of ways of raising children. The capacity for variety that we have is extraordinary. (…) The myth in our society is that people are competitive by nature and that... more... - Amira
Berci Mesko, MD
PLoS ONE: Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data - http://www.plosone.org/article...
Berci Mesko, MD
Doctors' knowledge of personalized medicine and genomics research remains poor - http://community.jax.org/genetic...
Berci Mesko, MD
Your Genome Structure, Not Genetic Mutations, Makes You Different | Wired Science - http://www.wired.com/wiredsc...
Berci Mesko, MD
Will people pretend to be African-Americans to get free @23andMe tests? - http://blogs.discovermagazine.com/gnxp...
Berci Mesko, MD
Genetic Music Project: An open source genetic art project combining music and science. - http://www.geneticmusicproject.com/
Berci Mesko, MD
When sociology meets statistical genetics | Discover Magazine - http://blogs.discovermagazine.com/gnxp...
Berci Mesko, MD
Genomic research: Faster, cheaper, more hope - Boing Boing - http://www.boingboing.net/2011...
Amira
"Drew Berry is a biomedical animator whose scientifically accurate and aesthetically rich visualisations reveal the microscopic world inside our bodies to a wide range of audiences. His animations have exhibited at venues such as the Guggenheim Museum, Museum of Modern Art (New York), the Royal Institute of Great Britain and the University of Geneva. In 2010 he received a MacArthur Fellowship "Genius Award"." More: http://tedxsydney.com/site... - Amira from Bookmarklet
Berci Mesko, MD
Biotechnology 101 Slides for Singularity University are available! - http://divabiotech.wordpress.com/2011...
Berci Mesko, MD
Berci Mesko, MD
DTC Genetic Testing and the FDA: is there an end in sight to the regulatory uncertainty? - http://www.genomicslawreport.com/index...
Berci Mesko, MD
Berci Mesko, MD
Press Release - @23andMe Database Surpasses 100,000 Users - https://www.23andme.com/about...
Berci Mesko, MD
FDA Approves New Test To Determine If Breast Cancer Patients Would be Candidates for Herceptin Treatment - http://ducknetweb.blogspot.com/2011...
Berci Mesko, MD
FuturePundit: Bigger Genome Projects Undertaken - http://www.futurepundit.com/archive...
Berci Mesko, MD
WHO Seeks Genomics Public Health Challenges | GenomeWeb Daily News - http://www.genomeweb.com/who-see...
Berci Mesko, MD
Direct-To-Consumer Genetic Tests Neither Accurate In Their Predictions Nor Beneficial To Individuals - http://www.medicalnewstoday.com/release...
Quote: ""They only take genetic factors into account when predicting risks for consumers, whereas in most multi-factorial diseases other modifiable risk factors, such as diet, environment, exercise and smoking have a much stronger impact on disease risk", said Professor Janssens. "We are all aware of the ethical problems surrounding DTC genetic testing, but this study also confirms that... more... - Nils Reinton
Quote II: ""Genome-wide scans by companies are totally unacceptable, as they can derive sensitive information about medically relevant conditions and will also provide lots of information which is difficult to interpret, even for medical professionals", said another respondent. Presenting the results of such tests directly to individuals is unacceptable, the majority of those surveyed said. " - Nils Reinton
Berci Mesko, MD
PHG Foundation | FDA continues crackdown on DTC genetics companies - http://www.phgfoundation.org/news...
Berci Mesko, MD
Personalizing Diagnosis, Treatment, and Monitoring of Cancer with Genetics - http://spittoon.23andme.com/2011...
Berci Mesko, MD
The '$1,000 genome' may cost $100,000 to understand - http://medicalxpress.com/news...
Berci Mesko, MD
Human Genome Project: How A 23 Chromosomes Made An $800 Billion Economic Impact - http://ducknetweb.blogspot.com/2011...
Berci Mesko, MD
Gene Testing Could Improve Screening Programme In Future, UK - http://www.medicalnewstoday.com/article...
Berci Mesko, MD
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