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Steve Koch, one of the most active practitioners of open science, announced today that he has not been awarded tenure, despite the considerable support he had received from the global open science community. He accompanied his announcement with an open … Continue reading → - Daniel Mietchen

So true! - Björn Brembs

Daniel, do these science3point0 posts still exist anywhere? Google is not finding this one. - Chris M

Expecting extensive abuse from the usual quarters in 3....2.....1...... - Cameron Neylon

...nah no worries. The fee is going to Creative Commons... - Cameron Neylon

Community  malaria research community Subject  Results, Request for Help, Project Fork Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)

Experimenting with chick peas & potatoes for one of the three batches.... (the tubs of chilli sauce top left are in the freezer for another purpose). This experiment also involves marinating diced chicken breasts (9) overnight which is new. #curry - Graham Steel

Right. Off to skewer and grill the marinaded chicken. PRO-TIP since a bit of food colouring was used, latex gloves are a must to avoid pungent/stained fingers/nails. - Graham Steel

Current topics in medicinal chemistry (25 October 2012) Numerical characterization of molecular structure is a first step in many computational analysis of chemical structure data. These numerical representations, termed descriptors, come in many forms, ranging from simple atom counts and invariants of the molecular graph to distribution of properties, such as charge, across a molecular surface. In this article we first present a broad categorization of descriptors and then describe applications and toolkits that can be employed to evaluate them. We highlight a number of issues surrounding molecular descriptor calculations such as versioning and reproducibility and describe how some toolkits have attempted to address these problems. Rajarshi Guha, Egon Willighagen - Egon Willighagen

Simple desalination. Scientists in the US have developed a membrane-free, solvent extraction method to remove salt from seawater that works at low temperatures. - David Bradley

great practical application of solubility data - Jean-Claude Bradley

Do you know where I can find more info on this solvent extraction process? - Scott Taylor from Android

Where are we up to? We've been busy working on the synthesis of the ten 'final' aryl pyrrole compounds chosen after the consultation in July.  This post is a brief summary of the current project status to let people know where we are up to and which compounds we still need to conquer.   So here we go:

What number is compound SB in the spreadsheet? e.g. OSM-S-02 - Andrew Lang

Tags: 3Dprinting resources - Bill Hooker

why no web service? - Andrew Lang

Thanks Rajarshi - I emailed him and he said 100+ is rejected - Andrew Lang

But seriously... not in the next four weeks... - Egon Willighagen

Heather Joseph was one of my panelists for LJ last week. When I asked about this, she said "ain't nothin' gonna happen until after the election, but there's been plenty of behind-the-scenes back-and-forth." - RepoRat

Congrats! - Noel O'Boyle