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ISMB2010:
ISMB
Keynote: Susan Lindquist - Protein Folding and Environmental Stress REDRAW the Relationship between Genotype and Phenotype
July 11, 2010
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Huy Q. Dinh, Ruchira S. Datta, Mickey Kosloff and 2 other people liked this
Inherited Environmentally acquired traits - lamarck wasn't so insane
- Ted Laderas
Protein folding - environment is very important ... showed videos
- Venkata P. Satagopam
experiments in heat shock tolerance -initial small shock allowed for survival -hsp proteins are made in massive amounts - role in protein folding
- Ted Laderas
Hsp90 a special chaperone.
- John Greene
from fftogo
in excess in cell - acts as homeostasis buffer
- Ted Laderas
Hsp90 a special chaperone.
- John Greene
from fftogo
hsp70 helps early stage folding and works with a number of proteins, but not hsp90.
- Dawei lin
HSP 90 a special chaperone ... because very abundant, it induced by two folds, it has extra folding capability .... acts as a buffer
- Venkata P. Satagopam
Signal transduction networks & HSP90 ... Hanahan and Weinberg, cell 2000
- Venkata P. Satagopam
showed signal transduction network involved by hsp90. It seems pretty spread.
- Dawei lin
hsp90's function is found by an accident.
- Dawei lin
Hsp90 mutations in fruit flies leads to death of flies
- Venkata P. Satagopam
some mutated fruit flies survived revealed that hidden genetic variant. Hsp90 does not destabilize development.
- Dawei lin
raise fly at high temperature can reduce the amount hsp90 level, easier than did it in a genetic way
- Dawei lin
Hsp90 a special chaperone.
- John Greene
from fftogo
acts as a capacitor for some variation .... it also acts as a potentiator for other variation
- Venkata P. Satagopam
both fly and arabidopsis experiments show that hsp90 acts a buffer for variations.
- Dawei lin
hsp90 can complex with inactive hormone receptors and oncogenic kinases
- Dawei lin
hsp90 helps mutated kinase, which lost the ability to inhibit itself.
- Dawei lin
same thing happened in human diseases.
- Dawei lin
so hsp90 inhibitor can be used for a drug.
- Dawei lin
there are a few fungi drugs available clinically
- Dawei lin
remove level hsp90 buffer level completely removed the drug resistance evolution
- Dawei lin
Raise temperature again eliminated the drug resistant development. Should the patient be put in fever stage.
- Dawei lin
talked about some unpublished data
- Dawei lin
Where is the bioinformatics ?
- arne
when added hsp90 inhibitor, some traits disappeared but some showed up
- Dawei lin
ame, people who analyzed the data, :-)
- Dawei lin
it should be a huge work to make genotype to phenotype map
- Dawei lin
the polymorphism in NFS1 that required for tRNA modifications caused the phenotype charge
- Dawei lin
polymorphisms in 3' UTR of HNI1 is also affected by hsp90, but not directly instead through the proteins binding to that region.
- Dawei lin
has Hsp90 left an imprint on genomes that exist today?
- Dawei lin
hsp90 affects polymorphisms throughout the genome even non-coding, in combinatorial way
- Dawei lin
it is benefit to human is the big reason to continue the research.
- Dawei lin
yeast prions - genetic element based on protein conformation
- Saravanamuttu Gnaneshan
prion also switches on with environmental stress
- Saravanamuttu Gnaneshan
prion has similar behavior of hsp90. It generates new phenotypes.
- Dawei lin