genetic reference populations: "fixed" populations - Michael Kuhn

BXD genetic reference population - Leopold Parts

BXD: homozygous strain - Michael Kuhn

F2 cross between DBA/2J (oldest inbred) and C57BL/6J (standard black) - Leopold Parts

inbreed the crosses, headed towards 100+ lines - Leopold Parts

have homozygous permutation of the parental genomes - Michael Kuhn

inbred strains originally to avoid southerns - Leopold Parts

GeneNetwork: http://www.GeneNetwork.org - Michael Kuhn

http://www.genenetwork.org - Leopold Parts

can select species and tissues - Michael Kuhn

can resemble the same genome over and over again: thus can suppress environmental influence - Michael Kuhn

dense microphenotypes for the bxd strains, specifically brain - Leopold Parts

few recombination events a problem - large linkage blocks with a lot of genes - Leopold Parts

can use geneNetwork to straightforwardly get a QTL map - Leopold Parts

and zoom in on cis and trans associatios, follow up genes, create expression network - Leopold Parts

then plot heatmaps for hypothesis generation - Leopold Parts

explore trans bands for the bxd collection. One for the pigment mutation. Many usually artefactual (in mouse datasets) - Leopold Parts