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HL46: Li Wang - Prioritizing functional modules mediating genetic perturbations and phenotypic effects
validation: ortholog lethal ration: the proportion of yeast genes whose orthologs in another species, specifically, C. elegans, are lethal - Ruchira S. Datta
hypothesis about ortholog lethal ratio: nonlethal genes in lethal complexes > nonlethal genes in nonlethal complexes - Ruchira S. Datta
hypergeometric enrichment test was not significantly different, but the Bayesian network model was validated. they think this is because the hypergeometric test produced many false positives - Ruchira S. Datta
gene lethality is more conserved at the module level - Ruchira S. Datta
use module-based mapping to transfer phenotypic mapping across species, rather than gene-based - Ruchira S. Datta