Sign in or Join FriendFeed
FriendFeed is the easiest way to share online. Learn more »
ISMB/ECCB
HL46: Li Wang - Prioritizing functional modules mediating genetic perturbations and phenotypic effects
validation: ortholog lethal ration: the proportion of yeast genes whose orthologs in another species, specifically, C. elegans, are lethal - Ruchira S. Datta
hypothesis about ortholog lethal ratio: nonlethal genes in lethal complexes > nonlethal genes in nonlethal complexes - Ruchira S. Datta
hypergeometric enrichment test was not significantly different, but the Bayesian network model was validated. they think this is because the hypergeometric test produced many false positives - Ruchira S. Datta
gene lethality is more conserved at the module level - Ruchira S. Datta
use module-based mapping to transfer phenotypic mapping across species, rather than gene-based - Ruchira S. Datta