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Jasper Estranero

Jasper Estranero

Second Year student studying Biological Sciences (Genetics)
Everyone seems to be talking about Google+. I'm actually considering to look into it though I don't have the slightest idea on what does it do.
Hope you guys are all enjoying the freedom.. I just wanna greet your dads and all the dads out there a Happy Father's Day! :)
The Show Goes On...
Technically, second year is over because the exams are over. But the fun does not stop there! While finishing my last task as a second year, which is to write a critical appraisal for a paper relevant to the third year project, I can’t help but have these little flashbacks that take me to as early as the first ever lecture that I had as a university student. Thinking to myself, where did all the time go? I guess I would have to attribute this to hardwork and basically enjoying as I went through it. This time last year, I was living the life of a ‘free’ person. Free from exams, free from revision, free to breathe easily. I have, pretty much, freedom written all over my face! Prior to this, I wrote this little reflection on what was it like to be a first year. A year later, here I am again being sentimental and looking back at what has been. They say that being a second year is the toughest among the three years of the course, but I find that hard to believe considering that the next... more... - Jasper Estranero
I loved reading that Jasper. You always make me smile. :) - Roisin Thomas
I don't want to worry you, but I'd say the third year is definitely the toughest. Sorry. That means you need a good break over the summer and come back refreshed next term. But don't turn your brain off entirely or it may be hard to get going again, so read a couple of books http://scireadr.com and hang around here occasionally. - Dr Alan Cann
@Roisin: Thank you.. I'm glad I can spread a bit of happiness.. Have a good summer! :) - Jasper Estranero
@Dr Cann: I am thinking of getting that book that you mentioned today in the seminar.. Something about the inventions of evolution? Sounds very interesting. - Jasper Estranero
Your very right Jasper there has been so many ups and downs this year but when you actually take the time to sit back and think about everything you have achieved, you realise how much it has been worth it and how much you have learned from it. I certainly think I've grown as a person and I have to admit, I'm proud of myself. Saying that, I'm proud of all my friends too and I have to... more... - Lyndsey Wright from iPod
Oh Lyndsey, you are just too awesome! I don't know how things would be like if I didn't meet you.. :) - Jasper Estranero
@Jasper - Life Ascending: The Ten Great Inventions of Evolution by Nick Lane - http://scireadr.com/life-as... Great book. - Dr Alan Cann
Finally finished going through the lectures for #BS2058 exam. Now onto some sample questions and then going over the material again.. We can do this guys! Almost there! :)
For #BS2058, I was just going over Dr. Willmott's Topoisomerases lectures and correct me if I am wrong: phosphotyrosine links form to hold DNA in place by gyrase. The hydrolysis of ATP would lead to the breaking of dsDNA which introduces a gap in the molecule. DNA is passed through the gap thus initiating supercoils. Does that sound plausible? :)
Your explanation there is not very clear. Both strands of the DNA form covalent links to the A-type subunits of gyrase via a phosphotyrosine link. The energy to fuel this is provided by ATP BINDING to the gyrase, hydrolysis resets the system to allow another round. - Dr Chris Willmott
just a quick question... Correct me if i'm wrong, but I remember you mentioning in your lectures that there are arguments whether hydrolysis of ATP takes place or not... Should we assume that it does take place or should we mention that ATP hydrolysis may take place at this point? - Andria Pelava
the debate is about where in the TopoII cycle ATP is hydrolysed not whether or not it is hydrolysed. Jim Berger suggests one ATP may be needed in the strand transfer phase but you can get one complete cycle of strand transfer with non-hydrolysable ADPNP. This kind of uncertainty/controversy is typical of real science and you'll encounter much more of this sort of unresolved question in Yr3 - Dr Chris Willmott
a ok! thanks! - Andria Pelava
@Dr Willmott: That made sense, thank you. - Jasper Estranero
Thoughts on #BS2058 Proteins The Machinery of Life timed essay
I just had a revelation that I may have messed up my #BS2058 timed essay yesterday which was worth 8% of the final module marks. The question was something like compare two ways of regulating proteins which I did (i.e. compared covalent modification and partial proteolysis). Then the second part was something like describe a biological process where two or more regulations are occuring at the same time. The ideal example was PKA but for some reason I did oxygen binding to haemoglobin. Worrying stuff! :-s - Jasper Estranero
Not like that you think you messed up, but like the reflection which will help you and others making the same mistake (if you have done) again. - Dr Alan Cann
O2/haemoglobin binding is regulated by allostery and an inhibitory molecule - BPG, and you might talk about pH effects. It seems like a good example to pick to me :-) I hope protein kinase wasn't the ideal one as I did ATCase! - Michael Steele
@Dr Cann: I may have also misread the question and misinterpreted it which added to the "panic factor" at the beginning. Yes definitely lesson well learned. - Jasper Estranero
@Michael: It's funny I was going to initially do ATCase but I blanked out after a few sentences so I switched to haemoglobin. To be fair though, I might just be making my own and others' dilemma by saying that PKA is 'THE' ideal example when in fact it could not be the case. But I just personally think it is.. :-s - Jasper Estranero
Could also do pepsin as an example as partial proteolysis and environmental effect. Don't worry Jasper, there were many examples to give and I'm sure you will be okay :) - Lyndsey Wright
Looking back on #BS1005
I must say that Biochemistry is not my strongest area of study and that is why sometimes I ask myself, "why did I pick a biochemistry module (i.e. #BS2058) knowing that I am quite slow at it?" Today was the first of the 3 series of lectures delivered by Dr. Chris Willmott on DNA and its regulation. It was nice that it was like taking a trip down memory lane when I first came into the university last year and my very first lecture ever was #BS1005 Introduction to Biochemistry. I don't particularly enjoy this part of biochemistry (again, I attribute it to being slow) but I have to say today's lecture wasn't that bad actually. It may take some time to get my head around it but hey, who said life is going to be easy? To top it all, Dr. Willmott made a hard concept quite easy to grasp with his funny side comments, metaphors and comparisons. Even with the regular Friday noon fire alarm tests at the Adrian which would go off randomly in the middle of our lecture and startle everyone right to... more... - Jasper Estranero
You're not slow at all. It's not an easy module and there's a lot to take in. Things will probably get clearer when you come to revise because you'll have more of an idea of how it all fits together. Also there will be more time to work on any tricky bits. - Roisin Thomas
I met up with my personal tutor to talk about my final year project. Now I have to do some reconsideration of the choices I have made because I did not realise how bad some of them were. Competition for those limited places is on!
Could you spell out a little more what you mean by bad choices? - Dr Alan Cann
Yeah, I'd like to know too. A few people have said their tutors have said that and I don't know what they mean. I also heard its a bad idea to choose an analytical project which is a shame because they are the only ones (that I'm eligible for) that look really interesting. - Roisin Thomas
It's not my tutor who said they were bad, it was me. Sorry, bad is the wrong word to describe my choices. More like it did not interest me the second time around. At first, some of them sounded like it had some interest factor to it but now I think I have to not include these and choose different ones. :) - Jasper Estranero
In no way is it "a bad idea to choose an analytical project", but it does depend on what you're intending to do when you graduate. If you're intend to do a PhD, we advise students to choose lab projects because these will give you the experience which will help you secure a PhD place. - Dr Alan Cann
I see. Thanks Dr Cann. I'm pretty sure I'm not going to be doing a PhD now so it's good that I can choose a project that I'll enjoy. - Roisin Thomas
Wow! Only 1 person (me) in the help session today. Dedication is definitely my thing this week!
85% on #BS2026 Research Skills Bioethics essay! Thank goodness, A-Level Philosophy :)
Oops, wrong module code...I meant #BS2060 - Jasper Estranero
Wow! Well done Jasper!! :) (You know you can edit your post?) - Joshua Bower
Nice one. - Roisin Thomas
Thanks.. Yeah I just love genes so much that I left it... :p - Jasper Estranero
Ha, fair enough :) - Joshua Bower
Amazing, well done Jaspeerrrr :D. x - Jaspreet Seehra
Finally finished with all of the practicals for this academic year. Where did all the time go? Just had the first ever #BS2058 Proteins The Machinery of Life practical..quite straightforward but very long and it could get very confusing.. :)
7 hours break between first and next lecture..Itinerary for today: continue with #BS2058 revision for timed essay next week and then work on problem sheet for #BS2026 for tutorial session this coming Thursday. Hope everyone is having a good day despite the sun not being here.. :)
Does anyone know the closing date for Student Finance applications for the year 2011-2012?
For returning students, it is 30th June 2011. That's what I found on the website anyway :/. - Jaspreet Seehra
#BS2060 Very pleased with my mark for the Critical Appraisal assessment. That help session last Wednesday was definitely a lot of help :) How is everyone doing so far?
It's a shame so few people were there. Still, more than the previous week (n = 0). - Dr Alan Cann
Well done Japser :) Proud of you! - Lyndsey Wright
I know the deadline of #BS2060 Critical Appraisal is Friday but does this mean by midnight tonight or midnight tomorrow night?
Deadline is today! - Dr Alan Cann
Oh okay.. At least, I'm nearly finished. Just trying to cut down the words as some of the contents I have put may be irrelevant. - Jasper Estranero
It has only been 2 weeks into the term and I feel like it has been forever. With so much work to do, I find that there isn't just enough hours in one day but I am definitely making the most out of it because Biological Sciences is just amazing! Hope you guys are coping well with workload.. :)
I had my first practical of the day and it definitely reminded me of the good old #BS1005 days.. We had to look at ascospores and score how many mutant/wild type forms there were per fruiting body. It was such a depressing task for my part because we didn't get to see much but it was fun doing it.. :)
Tomorrow is my first day back to uni and I already have a 6 hour practical. It's okay considering that I love the genes practicals. It sort of makes me nostalgic for first year's #BS1005 and second year's #BS2009 practicals. :)
Hello fellow friendfeeders, I have not been feeding for nearly a month now but definitely it will be back to being a daily-must. Hope everyone found their exams went well. Now that exams are over, we could set our gears onto second semester. Well done everyone! :)
#BS2009 Domain duplication leads to the elongation of the genes encoding for antibodies (correct?) When the different isoforms of antibodies are formed, do I then attribute this to domain shuffling? I am really confused...
Happy New Year everyone! :)
Anyone who does #BS2057 have the actual lecture slides to Dr Dickens' lectures? All there is on blackboard are the handouts.. Thanks very much! :)
No he didn't put them on blackboard. I've put that stuff on dropbox for you by the way. I've included a file which has the page numbers that correspond to the titles of the clips. - Roisin Thomas
Oh awesome..thanks so much..just in time actually because I'm already making my own notes on that lecture..hope you had an awesome christmas... :) - Jasper Estranero from fftogo
I just want to greet you amazing students and staff of Biological and Medical Sciences a very Merry Christmas..Hope you are all enjoying your holidays and for my fellow students, happy revision to you... Let's all pass our exams shall we? :)
Merry christmas to you too! :) - Roisin Thomas
Will be having my last day tomorrow. I finally finished doing the last of the tutorial questions and practical write-ups for this semester and the year 2010. Quite sad that the semester is now finished but at least there is Christmas to look forward to. Revision plan will be done soon to make sure I get everything.
Half way through our time at University... how scary is that? - Joshua Bower
Josh don't! *runs and hides* - Laura
The way Josh has put it, it sends shivers down my spine and at the same time it is quite depressing. I will miss all of this when I graduate.. =( - Jasper Estranero
#BS2057 Why is it that mutations with Intermediate Filaments are more likely to be involved with human inherited diseases in comparison to Actin Filaments and Microtubules?
Not really sure, but I think maybe its because they are invlved with so many nuclear processes that a mutation in the gene is more likely to cause a phenotypic effect? - Laura
These last few weeks will be a very busy week. I hope everyone is doing great with assessments and revision. Do have some break as well because it's nice to work with a fresh and well-rested mind! Keep it up you hardworking students of BioSciences.. =)
Wow, I just realised that the first sentence was one terrible grammar..Apologies.. =)) - Jasper Estranero
Thanks Jasper, I couldn't agree more with you on the working with a "Fresh and well-rested mind" part as over time I've realized myself how much of a difference it makes in learning and absorbing work that way, as opposed to working when extremely flat out. - Ahmed Syed
Rest is definitely important. Otherwise, what would be the point of working long hours when the quality of your piece would not be as great. Sleep is definitely a must for us! :) - Jasper Estranero
New superbug which is resistant to a variety of drugs - http://www.metro.co.uk/news...
It is very interesting to learn that there is something new that I could potentially work on in the future as a scientist. Then again with the excitement is the inevitable fact that the public would worry about a new epidemic that could happen. Following the outbreak of SARS, bird flu and AH1N1 virus, this superbug is another challenge especially in the field of science. At the same time, it gives people the opportunity to reassess their lifestyle and improve on things that could help reduce risks that pose as a global threat. - Jasper Estranero
I am just finishing accommodation tour training for the Leicester Ambassador..I think it will take some time to sink everything in considering that I have not lived in any of the halls at all..It was nice to meet a few first year BioSciences students as well.. :)
There's this one point that I missed in #BS2009 Genomes lectures today.. Does anyone know if anyone has recorded today's lecture?
Even though I am aware of the fact that I am predominantly a visual learner, I have come to realise that I am definitely more of an auditory learner than kinaesthetic as I played back the lecture recordings and started to build up on my notes. Suddenly, things are beginning to make sense and motivation to start revision has kicked in! :)
Sometimes, I need to hear it from someone so that a concept is reinforced in me but yes, a varied approach is the best indeed... :) - Jasper Estranero
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