Jean-Claude Bradley

Very cool. I'm beginning to like Vimeo more and more. - Andy Maloney

What's Vimeo? Is it like youtube, but less sucky? Is Vimeo:YouTube as Facebook:MySpace? - Steve Koch

Haven't used Vimeo as much as I like, but it is a great video service. Key features: allows high-quality upload and in their words "a respectful community". Cue xkcd reference: http://xckd.com/202/. - Neil Saunders

vimeo allows larger file size and greater video length than youtube - Mike Chelen

does vimeo take FLV files? - Jean-Claude Bradley

Jean-Claude: unfortunately vimeo does not support .flv upload, here is a list of their accepted formats: http://vimeo.com/help... - Mike Chelen

Mike - that's too bad - that's the only format I've found that maintains very high resolution with small file sizes. Guess I'll stick with SciVee for a while - Jean-Claude Bradley

Jean-Claude: how about blip.tv? they allow up to 1gb videos and seem to accept any format http://blip.tv/faq#format - Mike Chelen

Would like to have looked at this already, but seems like most blogs are inaccessible in China. Returning to Sydney today... - Matthew Todd

Andy - I would have to yes they are meaningless and should be marked as "solute reacts with solvent". In the same way that the solubility of NaOH in sulfuric acid is meaningless. This has implications for the Ugi reaction since methanol is a very common solvent. - Jean-Claude Bradley

congrats!! - Abhishek Tiwari

Congratulations. Is that C&E News, the famously open access journal? ;) - Matthew Todd

thanks everyone! Mat - there are times we have to be flexible :) - Jean-Claude Bradley

:) - Matthew Todd

Not just me- you also had support from my editor, Amanda Yarnell. Great to have you. - Carmen Drahl

Carmen - please forward my thanks to Amanda as well! - Jean-Claude Bradley

MERLOT, perhaps? - D0r0th34

Great idea - just added the Spectral Game to Merlot http://www.merlot.org/merlot... - Jean-Claude Bradley

Thanks, Dorothea! - Bill Hooker

Egon - yes the solubility of the Ugi products that have come out of methanol are on the order of 0.05-0.1M and the starting materials are above 2M - Jean-Claude Bradley

To clarify: if material comes out of solution after cooling, that's not considered a saturated solution, right -- more solid is added and it's re-sonicated? My concern is crystallization pulling solute out of solution, but perhaps the temperature ranges are not wide enough for this to be a practical problem? - Bill Hooker

Bill - if solute comes out after cooling we can be sure we have saturation. If after cooling (and sonicating to make sure we aren't supersaturated) we still have a clear solution then we need to add more solute and sonicate/heat again. I'm not sure if that answers your question... - Jean-Claude Bradley

My concern was that on cooling a supersaturated solution, more solute might come out than just whatever is excess to saturation. Is this not possible? Maybe I am just displaying chemical ignorance here, but when I've supersaturated solutions of salts or SDS by heating, much more appears to drop out on cooling than just the excess-to-saturation. I've never tested it by taking the supernatant and attempting to add more solute. - Bill Hooker

Bill - it should not be possible to have the solute concentration drop below saturation from a supersaturated solution. I am so confident on that point that it would blow my mind to learn otherwise. Does anyone out there have evidence that this is possible? - Jean-Claude Bradley

Nah, it's just some weird idea I got into my head. Happy to be wrong. :-) - Bill Hooker

The error from the internal standard is likely related to micropipetting problems, which is why I am so emphatic in using a method that requires no volume measurements. The SAMS error is related to the hydrogen chosen to do the integration and I think this comes down to relaxation time. The values are actually pretty good for the terminal methyl. I'll detail this shortly in a post. - Jean-Claude Bradley

That's what I thought -- I've had a bug up my ass about measurement error the whole time, and it's been clear since the first person compared hydrogens (Khalid?) that choice of hydrogen was important. (I was trying to nudge David to think along those lines with my comments on the wiki.) You probably have this covered in the post, but is there a way to generalize about hydrogen choice -- that is, predict which ones should be used? Otherwise we're stuck with cross-validation. - Bill Hooker