Jean-Claude Bradley

Ugi reaction on the free to publish OA Beilstein Journal of Organic Chemistry - Jean-Claude Bradley

What is going to distinguish chemistry databases as we move forward in this Web2.0 world? - Jean-Claude Bradley

Anna - that is interesting and another powerful reason for publishing OA - so that your articles will be found by your peers. Does anyone have stats on what percentage of PhD granting institutions have a subscription to SciFinder? - Jean-Claude Bradley

A final overview of student assignments for the class, mainly about finding and reporting on sources of molecular properties. - Jean-Claude Bradley

oh wait, that article's from 2008 - Richard Akerman

some info on Nature Network http://network.nature.com/groups... - Richard Akerman

Right Richard - Google Reader thought it was new :) As Cameron has said it doesn't hurt to have the odd long timescale loop on FF - if only for some of the new people joining - Jean-Claude Bradley

let me know if you see a surge in traffic tomorrow morning (GMT)//today - I posted your chemsearching skills scitv to my students ... - Anna Croft

This is the lecture from the 8th Chemical Information Retrieval class at Drexel University on November 12, 2009. It starts with a demonstration of how to use of ChemSketch and Chemspider to display and manipulate chemical structures, especially those with complicated stereochemistry. Technical issues with using SMILES between the two platforms are addressed, as are optimization of 3D structures and inverting chiral centers. Microsoft Paint is used to process screen captures to images that can be uploaded to Wikispaces. ChemSpider is also used to generate predicted properties. SDBS is used to retrieve NMR and other spectroscopic data. - Jean-Claude Bradley

this looks like a great blog for organic chemistry lab techniques - this post is very detailed on TLC - Jean-Claude Bradley

Mel Reichman, senior investigator and director of the LIMR Chemical Genomics Center at the Lankenau Institute for Medical Research presents at the chemistry department at Drexel University on November 12, 2009. Introduction by Jean-Claude Bradley. Modern drug discovery by high-throughput screening (HTS) begins with testing hundreds of thousands of compounds in biological assays. The confirmed hit rate for typical HTS is less than 0.5%; therefore, 99.5% of the costs of HTS are for generating null data. Orthogonal convolution of compound libraries (OCL) is 500% more efficient than present HTS practice. The OCL method combines 10 compounds per well. An advantage of this method is that each compound is represented twice in two separately arrayed pools. The potential for the approach to better enable academic centers of excellence to validate medicinally relevant biological targets is discussed. - Jean-Claude Bradley

Mel Reichman gave an outstanding presentation at Drexel on November 12, 2009. I think many of our faculty and students benefited from his unique perspective on high throughput drug discovery and the story of Vioxx from both chemistry and intellectual property considerations. Screencast and slides available here. - Jean-Claude Bradley

Make that a 'like, like, like' :-) - Graham Steel

Nice indeed..... - Graham Steel

Graham - if there ever was an abbreviation subject to miscommunication that would be it :) - Jean-Claude Bradley

a nice example of an organic synthesis blog - Jean-Claude Bradley

I found the premise of Barbara Bradley Hagerty's new book "Fingerprints of God" quite intriguing.  The author, raised as a Christian Scientist, attempts to look into alternative religions and science to see if her faith is justified.  There is nothing really new here - in terms of topics that have been covered in many other popular books.   But what I found interesting was her interpretation of her experiences and investigations.  She chronicles her struggles and revelations in an autobiographical format - and I'm usually a sucker for autobiographies. read more - Jean-Claude Bradley

Polymers are where the problem with assuming that chemistry is structure centric come home to roost of course. Nico Adams has been looking at developing ways of describing polymers effectively and it really isn't straightforward. The whole notion of substance, chemical, and structure get very very messy. - Cameron Neylon

Martin Ott moved to Sheffield... (http://www.lhasalimited.org/index...) I'll try to ping Vriend about the future of BioMeta... or the code behind it. - Egon Willighagen

Interesting. This was bound to happen eventually. It's "Friendfeed for scientists", except that it's a little cluttered and hard to find your way around. - Mr. Gunn