Lars Juhl Jensen

1. What are your essential everyday resources for biomolecular data? 2. What are the typical questions you need to answer (and is the 2003 Nature Genetics guide still useful)? 3. Can you recommend any more tutorials / guides? - Pierre

Egon discusses the process of working with rdf data derived from the ONS challenge experiments - Cameron Neylon

With Alchemy, Web application developers can now reuse hundreds of millions of lines of existing open source C and C++ client or server-side code on the Flash Platform. - Pierre

@Pawel by the way, at the end, is your visual-cv static or is it a dynamic image ? - Pierre

Pierre, it's static - but original is in SVG from Inkscape, which means it should be easy to translate it to dynamic form. - Pawel Szczesny

"[W]omen accounted for only 12 percent of undergraduate degrees in computer science and engineering in the United States and Canada granted in 2006-7 by Ph.D.-granting institutions, down from 19 percent in 2001-2. Many computer science departments report that women now make up less than 10 percent of the newest undergraduates." Only 0.3% of incoming female freshmen list computer science as a probable major. Unfortunately while this article asks a great question, it only provides stats and doesn't provide an answer. - Hilary

Not an article that I "like"... :( - Hilary

Interesting how different people find different things that interest them: http://pandagon.net/index.php/... - Bora Zivkovic

Bora - Yeah, seems like Gladwell is getting criticised from a lot of points of view. I still enjoyed it. - Michael Nielsen

@Pierre, you going to SWAT4LS? - Duncan Hull

no :-( sometimes I just found it's a too bad that such workshops are not registered on upcoming.com. Semantic Web is just a leisure for me and I would attend this meeting if it was closer to me. - Pierre

With embedded DC / PRISM / MRSS data. Example here: http://precedings.nature.com/u... You can now automatically add your Precedings posts to FriendFeed using the "Blog" service (e.g. generic RSS import). If you would like to see a custom import of Precedings feeds for FriendFeed, please contact the FF folks to suggest adding it: http://friendfeed.com/about/co... - Hilary

These things are exquisitely sensitive to ionic concentration, which makes them a little difficult to work with, since all your buffers have to be adjusted to within nanomoles of one another in salts. - Mr. Gunn

I've never understood how you can make systems like this scale adequately. For high throughput you need to wire up thousands or millions of pores, which can be done, but not manufactured cheaply. But you need it to be cheap because the pores are likely to get blocked. Still there are some very smart people who I have a lot of respect for working for the Oxford company - I expect they've certainly got solutions in mind - Cameron Neylon

Kevin Kelly often writes that it's a wrong bet to say that something is technologically impossible, so I'm pretty sure they will find the way :). - Pawel Szczesny

Oh yeah - I'm just intrigued as to _how_ they're going to prove me wrong :-) These are not people I would choose to bet against on finding a technological solution - Cameron Neylon

"We observed that microRNAs (miRNAs) that regulate differentiation in a variety of simpler systems also regulate differentiation of human multipotent stromal cells (hMSCs) from bone marrow. Differentiation of hMSCs into osteoblasts and adipocytes was inhibited by using lentiviruses expressing shRNAs to decrease expression of Dicer and Drosha, two enzymes that process early transcripts to miRNA. Expression analysis of miRNAs during hMSC differentiation identified 19 miRNAs that were up-regulated during osteogenic differentiation and 20 during adipogenic differentiation, 11 of which were commonly up-regulated in both osteogenic and adipogenic differentiation. In silico models predicted that five of the up-regulated miRNAs targeted leukemia inhibitory factor (LIF) expression. The prediction was confirmed for two of the miRNAs, hsa-mir 199a and hsa-mir346, in that over-expression of the miRNAs decreased LIF secretion by hMSCs. The results demonstrate that differentiation of hMSCs is regulated by miRNAs and tha" - Attila Csordas via Bookmarklet

Like, except for the fact that M. Whitney, not mentioned on the paper, did the bulk of the LIF1 work in that lab. Her defense is next week, too. - Mr. Gunn

hope Mandolin is alright baby included, give my regards to her - Attila Csordas

A trust in consensus decision making underlies many of our democratic political and judicial institutions, as well as the design of web tools such as Google, Wikipedia, and prediction markets. Here, we show how small groups of sticklebacks (Gasterosteus aculeatus) reach consensus when choosing which of two replica fish to follow. - Pierre

Bora points to various reviews of Gladwell's new book, all of which seem to take something different away from it. - Michael Nielsen

Someone from Nature will be there and blogging the conference. Not sure who yet - most likely one of our science journalists - but watch this space so you can meet up if you like: http://blogs.nature.com/news/b.... - Maxine

Seem to have missed them. The meeting had a bit of a disjointed feel this year - or maybe it's just that it's the 6th week travelling for me. I think I'd met Magdalena a few years ago at CSHL/Genomes - she might even have still been with NRG? - Chris Cotsapas

Yes, she hasn't been with Nature for very long. She was briefly a publisher for NPG after leaving NRG, but now is back on the editing beat, I'm glad to say - she has replaced Chris Gunter at Nature. - Maxine

http://support.creativecommons... - Pedro Beltrao

...and the last thing we can do is hopefully break down some of the old boys club that really dominates a lot of the access to the research materials in science, right now it's not who you are and how smart you are it's who you know and where you work... - Duncan Hull

I agree with Paulo -- many of the existing aristocracy will push back hard on anything that threatens to move science towards a "meritocracy". Can't talk about it just yet but have been smacked around a little myself. Off with their 'eads I say! - Bill Hooker

Don't forget that the interwebs also has this kind of things. Some people can get away with anything they post/publish/write, some people comment/post/write better and never get heard/read. Like Lars said. - Paulo Nuin

Inspired by, but not affiliated with Wikipedia, we are building a searchable, editable, and expandable collection of tunes, melodies, and musical themes. Every entry can be edited by anybody. An entry can contain a bit of sheet music, a MIDI file, textual information about the work and the composer, and last but not least the Parsons Code, a rough description of the melodic contour. - Pierre