Same for math. In math there are infinitely many theorems mathematicians could set out to prove, but only a relatively small "fraction" are remotely interesting. (Although what *exactly* makes the interesting ones interesting is enigmatic.)
- Mark Changizi
Well, I'd take that as a another parallel, then :-) Add yet another one: there are fake ones! :-)
- Björn Brembs
Come to think of it, I don't think I'd say boring, either. Less interesting, maybe. If it were truly boring, wouldn't that mean it would be known and then it wouldn't be a discovery?
- Björn Brembs
Well, be careful with the rest of the analogy. Now what would you say of peer review? Reviewers have to reproduce the results (and reach the exact conclusion) or at least order it to be reproduced by the authors!
- Ramy Karam Aziz
Here's how I got into it: First I checked out people's subscriptions and subscribers to find out who posts interesting stuff. Then, I was back to FF constantly, just to get all this interesting info. Once I got to see that people were not only posting cool science, but also discussing it, I was hooked.
- Björn Brembs
Thanks Bjorn. But do you also go on Twitter? Or only here?
- Mark Changizi
I would also suggest looking into groups, which may aggregate topics rather than people. I only post in the groups when I think it may be of interest to them, but someone in there does not need to subscribe to me to see that. Using the best of week is a great feature. I have to say that I love that Bjoern posts his likes and comments through twitter, but because there is heaps of overlaps on interests. Agree with Bjoern, less about the post and more about the discussion
- Kubke
I only go to Twitter every 2-3 days to see if someone tweeted something @myself (and on some special occasions of current developments, which is very rare). Twitter has no threaded discussions and everything drifts out of focus within minutes. Here, I can get "best of day" or week and all the interesting stuff stays on top for as long as it remains interesting. see also: http://bjoern.brembs.net/comment...
- Björn Brembs
I often "like" something here because I want to broadcast it via Twitter and Facebook whenI think people ought to know about it.
- Björn Brembs
The threaded discussion for me is the key. Most of you people do the interesting talking while I am sleeping here at the other end of the world. But I can always come back to it. Would be impossible on Twitter.
- Kubke
Interesting. Twitter I've given up on keeping up with. Too stressful to even try! It's like email on crack. (I've developed a once-a-week Twitter regimen.)
- Mark Changizi
ha ha! You don't need to go all yellow submarine on FF. Every time you 'like' something it will point it to your subscribers, and you will see what the people you subscribe to like because it will be moved to the top of your page. If you click on your name top right, you can then look at the discussions you liked or commented on and see if anything has been happening there (useful), and...
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- Kubke
I like this 'for example' they give: "Embryo rights campaigners, for instance, are invited to question not only the morality of stem-cell research, on which they are as qualified to speak, but also its usefulness, on which they are not."
- Kubke
Right, it'll only change humanity forever. ;-)
- sanki
No it won't :-) That's wishful thinking. They've known the connectome of Caenorhabditis elegans since 1986 and almost 25 years later, we still don't know what makes these 302 neurons a brain...
- Björn Brembs
That's my refrain, too, Bjorn. If we can't make sense of C elegans despite our God's eye view of it, we're screwed for our 10^10 neuron brain... (I typically follow up with: We need much much more attention to the function of our nervous system. See 3rd paragraph and following of ... http://bit.ly/5A83Yn )
- Mark Changizi
Yes, Mark, love that post! Which is exactly why the current trend of dropping invertebrate model systems, ironically, does not bode well for human brain research.
- Björn Brembs
I was just kidding, Bjorn, about the impact of the project. Remains to be seen, right?
- sanki
Bjorn what do you think is missing in our understanding of the elegans brain? Hormonal effects?
- Jean-Claude Bradley
@sanki - I figured, hence the :-) It will be very valuable and it of course is an extremely important and exciting project. There cannot be any proper biological understanding without anatomy! That doesn't mean that anatomy is all there is to know and I really appreciated the description of the project on the site which was exactly spot on.
- Björn Brembs
@Jean-Claude - that's definitely one important aspect. But there are more: the dynamics with which the connectivity changes, the many different types of synapses and how dynamic transmitter release can change. Multiple transmitters being released from the same synapse. Receptor recycling/turnover, etc. Some if not all of these variables are under hormone or modulator control, which...
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- Björn Brembs
Bjorn - so there are no models that take into account the way transmitters are released and receptor behavior? That can't be a computational limit for the model building I would think. Is it just that the factors are all known but not all the measurements are in?
- Jean-Claude Bradley
The 'connectome' is only about which neuron is connected to which. All the rest of it still has to be entered into the model. For some synapses, some of the dynamics are known. Given that each of the 100 billion human neurons connects to about 10,000 others, getting the total dynamics of each single connection will take some time, if it is technically possible.
- Björn Brembs
lol :-) That explains why I found your comment so confusing :-) I'm not really up to date on what the status for C. elegans is right now. I'm certain the C. elegans papers would read quite differently, if they had a working model of that brain :-) I have a lecture coming up in a month which may require me to do some reading in this regard. I will let you know should this happen.
- Björn Brembs
thanks Bjorn - I would be interested to see what you find out.
- Jean-Claude Bradley
"Outsiders to the cognitive and brain sciences can sometimes get the impression that we brain scientists have nearly unraveled the riddles of the brain. While it is true that we are making great strides, the real question is, How far away from the finish line are we? Alas, I believe we are nowhere near the finish line; I put my money on several hundred years of brain-slogging left to go. Keep in mind that your brain is more complicated than the rest of the universe combined (minus all the other brains). Truth is, relative to what needs to be known, we don’t know jack."
- Björn Brembs
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