"Having tested over 3000 different substances, he found that a red dye which became known as prontosil worked well against streptococcal infections in laboratory mice, even at very low doses, though it did not work in test-tube tests against the bacterium. "
- Matthew Todd
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hi i have been tring to get in touch with you herve recomned that i meet with you i need some advice please
- Roy Mcveigh
Asymmetric Hantsch compound. Nice stereochemical issues. Successful Pfizer drug. Heard Simon Campbell talk about this at UCL a few weeks ago.
- Matthew Todd
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Animations of common chemical reactions. Warning - let your browser load the Java applet - it's probably not crashed...
- Matthew Todd
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"The FDA has approved Eisai's Halaven (eribulin) for late-stage breast cancer. As far as I can tell, this is now the most synthetically complex non-peptide drug ever marketed. Some news stories on it are saying that it's from a marine sponge, but that was just the beginning. This structure has to be made from the ground up; there's no way you're going to get enough material from marine sponges to market a drug."
- Matthew Todd
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Intermediate steps in Combes quinoline synthesis. The third step is an ugly shorthand that I'll accept - in reality the OH is protonated, and then the nitrogen kicks its electrons in. Reaction arrows are all shown as reversible, which is fine here. Some are more reversible than others...
When Drug Molecules Look in the Mirror - Journal of Chemical Education (ACS Publications and Division of Chemical Education) - http://pubs.acs.org/doi...
"The presentations that work are not the ones with the most data or the most elaborate charts and graphs; the winners are those with the most compelling and convincing narratives." One for everyone who gives powerpoints - and particularly our current batch of Hons students.
- Matthew Todd
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How to make a bagel into two interconnected moebius strips. "If your cut is neat, the two halves are congruent. They are of the same handedness. (You can make both be the opposite handedness if you follow these instructions in a mirror.)"
- Matthew Todd
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"The team produced the spheres from N-tert-butoxycarbonyl (Boc)-protected diphenylalanine, which in unprotected form is the core of the beta-amyloid protein that accumulates to produce plaques in the brain in Alzheimer's disease ... 1um diameter particles where the dipeptide shell was 0.4um thick had a 275GPa Young's modulus, compared to 130GPa for Kevlar and around 200GPa for steel."
- Matthew Todd
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"Chemistry is one of the great non-verbal disciplines. In so many ways it reminds me of music." Nice article by a non-chemist about chemical structures and their representation.
- Matthew Todd
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Interesting choice of music and amusing slow-mo replay of C-terminus folding. Interesting also that Stanford is able to copyright this, given it was a distributed computing effort. Perhaps the copyright just applies to the movie production.
- Matthew Todd
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