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SEEDMAGAZINE.COM § A Miniature Miscellany - http://seedmagazine.com/slidesh...
Beautiful nano gallery from Whitesides book
- Matthew Todd
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LabTube – videos for the scientific community - http://www.labtube.tv/
Seems to be swamped with commercial videos at the moment, however.
- Matthew Todd
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Academic Family Trees - http://intermolecular.wordpress.com/2009...
Anyone from Connotea read/use Friendfeed? RSS import from my Connotea group into FF isn't working.
Puzzle of Tangential Relevance to Organic Chemistry - http://intermolecular.wordpress.com/2009...
Heterocyclic Mechanisms – Isopyrodysinoic acid - http://intermolecular.wordpress.com/2009...
Khalid Mirza and Jean-Claude Bradley liked this
Wondering why your blog was not aggregated by Chemical blogspace yet... http://cb.openmolecules.net/
- Egon Willighagen
The cyclization might happen if the alcohol could be protonated with an acid catalyst. You have the huge benefit of forming a 5 membered ring.
- Jean-Claude Bradley
Egon - just set the blog up. Finally. JC - I think even with the protonation, a direct displacement would be difficult. With that double bond in there, and the flattish amide, I don't think the nitrogen can reach round to do a direct displacement.
- Matthew Todd
Mat - sure it has a lot going against it but might still be worth trying
- Jean-Claude Bradley
I'd be tempted to deprotonate (you're stabilized by both alcohol and delocalisation back to the carbonyl oxygen) transfer the proton to make the hydroxylamine and then attack with amine. It's now 5-endo-tet(ish) so you've got the flexibility in the five membered ring now to position the amine for attack, make the five membered ring then another proton transfer to product....damn that mechanistic chemistry is rusty...
- Cameron Neylon
I would expect the allylic carbocation should form in the presence of acid pretty easily. The question is - is that amide N nucleophilic enough to cyclize? Since you are making a 5 membered ring that isn't crazy to expect (although it might cyclize via the amide oxygen as well)
- Jean-Claude Bradley
actually I remember a question like this in a workshop..."What do Baldwin's rules tell you about the cyclisation of the cyclisation of this nucleophile onto that carbocation to form a five membered ring?" Answer absolutely nothing because it is charged... :-)
- Cameron Neylon
Cameron, I think we need to deprotonate, but we're in acid, so whaddya mean? (This making you nostalgic?)
- Matthew Todd
Help for molecular analysis of S.haematobium from cameroon | The Synaptic Leap - http://www.thesynapticleap.org/node...
Jean-Claude Bradley, Andrew Perry, Neil Saunders and Greg Tyrelle liked this
Request for experimental help from Cameroon scientist working on genetic diversity of schistosomes
- Matthew Todd
from Bookmarklet
Chemspider and Structure of Digitonin - http://intermolecular.wordpress.com/2009...
Frontiers of Science { Home } - http://frontiers.library.usyd.edu.au/
 |
Science fact comic strip originating from the University of Sydney and syndicated worldwide through over 600 newspapers from 1961 to 1982.
- Matthew Todd
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the Tropical Disease Initiative » Blog Archive » TDI presented at Duke-NUS (Singapore) - http://tropicaldisease.org/...
Sakai Project : Home : About Sakai - http://sakaiproject.org/portal#
Mickey Schafer liked this
Has anyone ever used Sakai for collaborating on a research project? "The Sakai CLE is a free and open source Courseware Management System. It features a set of software tools designed to help instructors, researchers and students collaborate online in support of their work--whether it be course instruction, research or general project collaboration."
- Matthew Todd
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my friend at Yale tells me they use it for all their undergrad courses and works great for that.. (rather than using not-free webCT)
- Alex Holcombe
My university (large, 45,000 students, research-driven) has just voted to use Sakai, and to appropriate necessary funds for training, infrastructure, etc. We are done with WebCT!
- Mickey Schafer
Not only that, but after opening my yapper to my supervisor, I am now chair of the committee to create our unit's shell. I really need to think more before pressing send;-).
- Mickey Schafer
Check out the case studies -- the Kapio-Lani one is interesting with the emphasis on ePortfolios -- lab-based science is not unlike "cooking" in that students must manufacture their own results in both cases. The portfolio function means that students keep examples of their work as part of a career-long record -- in a bio lab, this would useful, wouldn't it? Being able to record what...
more...
- Mickey Schafer
Google targets Microsoft with new operating system |
Technology |
guardian.co.uk - http://www.guardian.co.uk/technol...
Anyone else interested by the idea of a Google OS? I am very impressed with Chrome. Surprised it still commands such a small market share.
- Matthew Todd
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Confluence - Enterprise Wiki - http://www.atlassian.com/softwar...
...and has anyone used Confluence for research projects? Free for non-profits and open source projects. Screenshots look a little like Wave, to my untrained eye.
- Matthew Todd
from Bookmarklet
We have it at our uni. It's a bog-standard wiki, so works as well or badly as others. Editing with Office software looks useful for getting people to use it, but our installation doesn't do this so I don't know how well it works.
- Bob O'Hara
Bob, it looks like it's designed for a select group of pre-defined collaborators, is that right? Unlike a FF room, for example?
- Matthew Todd
Yes: you have to give permissions to use and see. I think you can make them global, though.
- Bob O'Hara
Symmetry Gallery - http://symmetry.otterbein.edu/gallery...
Abhishek Tiwari, Chem Nut and Egon Willighagen liked this
Lovely interactive site on molecular symmetry. Thanks Rich http://zusammen.metamolecular.com/2009...
- Matthew Todd
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The Sceptical Chymist: Reactions - Ian Fleming - http://blogs.nature.com/thescep...
Ian Fleming interviewed. Superb organic chemistry lecturer.
- Matthew Todd
from Bookmarklet
Centre for Human Aspects of Science and Technology, Sydney Uni - Lee Felsenstein - http://chast.org/
Going to talk by Lee Felsenstein in a few minutes on the Social History of the Personal Computer
- Matthew Todd
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More Talk, Less Chalk: Lexically Sparse Slides Improve Recall of Taught Material - http://www.psychologicalscience.org/cfs...
Peter Miller, Jean-Claude Bradley, Hilary and Mike Chelen liked this
Study showing use of bullet-point text in presentations impedes audience learning. Have been saying this for years - nice to have some evidence.
- Matthew Todd
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TotallySynthetic.com » Blog Archive » Himandrine - http://totallysynthetic.com/blog...
Lovely Himandrine synthesis from MIT. Victor, check out the NCS step, and read the paper to see how they proved the mechanism. Initially looks like extended enolate attack onto N-Cl, as per Woodward quinine synthesis.
- Matthew Todd
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Computational Organic Chemistry » Mannich reaction - http://comporgchem.com/blog...
joergkurtwegner liked this
Bachrach blog post about recent computational work on proline-catalysed Mannich reactions.
- Matthew Todd
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Before and After Shots of Google's Iran Maps - O'Reilly Radar - http://radar.oreilly.com/2009...
Ahmet Yükseltürk and Michael Nielsen liked this
Rapid crowdsourcing maps of Tehran
- Matthew Todd
from Bookmarklet
We're looking into getting a new lab inventory management system. Does anyone have experience with a tracking system for chemicals/samples in their lab? How do people manage incoming/outgoing bottles? Do people do stock-takes, or do people have real-time knowledge of what's in their lab? Does anyone here bar-code all chemicals?
Mike Chelen, Abhishek Tiwari, Paul Bacchus and 2 other people liked this
We bought a developer license to thishttp://www.chemoventory.com/ and then made major modifications to this. It is isn't the greatest piece of software. But the developer doing the modifications is extremely inexperienced and the architecture is extremely simple and easy to modify.
- Zaki Manian
Have a look at megaventory.com. SaaS model, texts and features can be easily customized by the user to fit into the lab environment and a cool user interface. The free (basic) version will be ok if you have just one lab.
- Kostis Mamassis
Hey Matthew i am part of a start-up Scrazzl.com that is developing a new inventory tool for active labs. We are actually looking to recruit beta-testers at the moment if you are interested?
- Dave
This is all great stuff, thanks guys. We've seen some good commercial solutions, which do what we want, but are expensive. I have this nagging feeling that tracking e.g. 50K bar-coded items in a building should be incredibly straightforward these days, but don't have the knowledge to say if that's so. Chemicals need a location (which can change), need to be entered on the system when...
more...
- Matthew Todd
we just use Google spreadsheets
- Jean-Claude Bradley
When I was at Sandia National Labs, they had a system that seemed to work pretty well and could do some of the searching you're talking about. Every chemical we purchased was screened and barcoded before arriving in the lab. To dispose of them, you typed in the code on a website before throwing away the empty bottle. http://www.efcog.org/wg...
- Steve Koch
On a separate note, Bill Flanagan at OpenWetWare has been talking with Anthony and I recently to rejuvenate the OWW barcoding talk. So far, he's succeeded in using Google's ZebraCrossing (http://code.google.com/p...) to: (A) create a 2-D barcode that encodes a page in the database and (B) software that decodes bitmaps of barcodes and redirects to the corresponding page. Thus, a...
more...
- Steve Koch
Has anyone ever written a History of Collaboration?
Cesar Sanchez, Seb Paquet, Michael Nielsen and 3 other people liked this
I think there is quite a large literature in social sciences on this but I don't know anything much about it or who would.
- Cameron Neylon
when you say history - do you mean in general, in science, or in computer mediated communication?
- Christina Pikas
There's a very short summary, plus prospective by Saveri, Rheingold and Vian at http://www.rheingold.com/coopera...
- Seb Paquet
and a fragmentary timeline of social software on the Many-to-Many wiki at http://www.socialtext.net/m2m...
- Seb Paquet
Nice links Seb. I was thinking actually less of the computer-mediated emphasis, and more on the story of how people have worked together to solve problems. Naturally the modern age part would be concerned with technical developments. But how did people in Ancient Greece collaborate? How did people work together to siege castles - i.e. the planning and the execution? How did people publish collaborative science in the 18th Century? etc.
- Matthew Todd
Yeah, I thought so. I think a lot of it boils down to what we would call today info sharing, deliberation and decision-making practices. If you do find such a history, please share! The closest I can think of is Bloom's Global Brain - http://www.amazon.com/exec...
- Seb Paquet
DESIGN AND USAGE OF MASSIVELY MULTIPLAYER ONLINE GAMES AND PERSISTENTIMMERSIVE SYNTHETIC ENVIRONMENTS - NNG09AZ32R - Federal Business Opportunities - https://www.fbo.gov/index...
Mike Chelen, Michael R. Bernstein, Andrew Lang and Jean-Claude Bradley liked this
"The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center’s Learning Technologies Project Office (LTPO) has released a Cooperative Agreement Notice (CAN) to conduct research and evaluation on the design and usage of Massively Multiplayer Online Games (MMOG) and Persistent Immersive Synthetic Environments (Virtual Worlds) for NASA Science, Technology, Engineering and Mathematics (STEM) Education and Training. Proposals should provide evidence-supported approaches, techniques, and tools that are grounded in education research that contribute to collaborative research for improving STEM education via gaming and simulations; and stimulate linkages and connections to and from secondary education and higher education and informal education communities using NASA content within a gaming context." i.e.NASA will pay you to develop games for science education. J-C?
- Matthew Todd
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Always wanted to work for NASA. When I was 16 I wrote to NASA asking for a job. They wrote back saying they couldn't hire me because I wasn't an American citizen - nothing about my age. :)
- Andrew Lang
one of our grants people just forwarded to me as well - we'll have to see if it can be on chemistry
- Jean-Claude Bradley
chartbeat - real-time website analytics and uptime monitoring - http://chartbeat.com/
Real-time monitoring of site activity. Only trial period free, however.
- Matthew Todd
from Bookmarklet
Black clouds turn Beijing day into night |
Environment |
guardian.co.uk - http://www.guardian.co.uk/environ...
This was really spectacular. Day turned to night, with cracks of thunder that made me jump.
- Matthew Todd
from Bookmarklet
SCIENCE COMMENT - Science Comment - http://www.sciencecomment.com/index
Site encouraging discussion of papers. Very low traffic at the moment - perhaps because the interface is a little awkward? Being able to comment on papers in situ at the journal page would remove the need for this site altogether, I guess.
- Matthew Todd
from Bookmarklet
I don't think a site providing commenting functionality alone will succeed- it needs to provide some further value to attract sufficient visitors. Don't forget search engines like Alf's http://scintilla.nature.com/convers... that try to aggregate paper comments wherever they occur- journal websites, as well as blogs, may be the future. We need to create new sharing tools that get conversations going, to be harvested by search engines perhaps
- Alex Holcombe
Alex - did you see the posts about streamosphere, yesterday? http://ff.im/40bks
- Matthew Todd
wow thanks- yeah I guess that's what I was talking about :)
- Alex Holcombe
Other models for offsite review: Naboj (http://www.naboj.com/), JournalReview.org (http://journalreview.org/v2/), BioWizard (http://www.biowizard.com/)
- Bill Hooker
Blowin' In The Wind: How China can win the Nobel Prize - http://www.pressrun.net/weblog...
Learned over dinner last night that China has never won the Nobel Prize. Find that quite amazing.
- Matthew Todd
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