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Sally Church
PTEN dosage is essential for neurofibroma development and malignant transformation — PNAS - http://www.pnas.org/content...
October 28
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Patients with neurofibromatosis type 1 (NF1) carry approximately a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST). Although the molecular mechanisms underlying NF1 to MPNST malignant transformation remain unclear, alterations of both the RAS/RAF/MAPK and PI3K/AKT/mTOR signaling pathways have been implicated.
- Sally Church