#BS1005 or #MB1005: I have forgotten why the sum of the intervals (between genes) does not exactly equal the map length and cannot find an explanation in the lecture notes (Dr Meacock's 6th Lec).
"Length of map is sum of lengths of intervals" It just doesn't equal 100%. Does this help?
- Thomas Webber
I think his question means why ro and ss is 28%? (see Dr Meacock's lecture 6th page 14) e and ss and e and ro is 12% and 20% respectively so if add them together, it should be 32%. Why 28%? I remembered Dr. Meacock explained this but I have forgotten too.
- Sha Tim Wai
i m not sure about this but i think that, length between genes using RF values are just representing the relative positions of the genes in relation to the other. Don't forget that cM values on a gene map can have any value (there is no theoretical maximum) whereas for RF values there is a maximum of 50%
- Christos Kyprianou
correction: cM values represent relative positions of the genes (not RF values). RF values represent the probability of crossing over between 2 positions
- Christos Kyprianou
Spider venom-derived neurotoxin may assist research into heart, other diseases | Health | The Earth Times - http://www.earthtimes.org/health...
Here is a nice, short article that arguably has links to all of the module studied this term. It particularly links #MB1004 and #MB1005. Certain diseases can be studied using a neurotoxin from spider venom that blocks receptors that are also blocked in the development these diseases. As it is not possible to extract the venom from the spiders in large enough quantities to work with, the toxin gene has been inserted into plasmids and the recombinant DNA transformed back into E. coli. The toxin is then produced and harvested in a similar way to which insulin would be harvested for diabetics.
- Max Levin
from Bookmarklet
I haven't posted in a while on friendfeed as I have been both busy and lazy. I am back though and, as I have already hinted, think there has been quite alot of work recently. Presentations, posters and report in most module have meant there has been more work than last semester. #BS1011 has also increased in difficulty. Whilst being quite good at maths, I've always struggled with statistics, perhaps through lack of interest, but now I can see its application to my degree stream I'm less apprehensive. I really enjoyed the #BS1006 practical two weeks ago and was intrigued to see the difference in breathing rates/volumes between rest and exercise. Hopefully the one tomorrow will be similar, off to go and read up on that.
- Max Levin
#MB1005: if one tautomer changes base pairing from A:T, C:G to A:C, T:G, would two tautomers (e.g. imino-A and enol-T) resume normal base pairing? (I know this would be extremely rare but I want to know out of principle)
Here is good article that discusses a question I have often asked, relating to #BS1009. Viruses are interesting to me because they so far seem to be the group of 'organisms' closest to being 'dead': note how Stanley won the Nobel prize in chemistry, not in phsiology! Seeing in the #BS1009 lectures how simple viruses can be poses the even more complicated questions 'What is life?' and 'Will we ever know?'
- Max Levin
from Bookmarklet
I think the statement, 'viruses lead a borrowed life,' is how I look at it. Essentially 'Dead' in the inactive form but as good as alive within host cells. I don't think we will ever know what life is because it is such a complex question to answer simply but it is an interesting topic/debate.
- Arnold Gangaidzo
That's not a bad outlook. Personally I think life is an illusion, like time. I think we are as alive as viruses and they are as alive as rocks. Controversial, I know.
- Max Levin
I recently recieved my results for the first semester exams and am currently working at a high 2:1. This is what I expected although I'd like a first class mark at the end of the year (and degree) so need to get my head down to bring up the average. I just completed this weeks #BS1011 assessment and got 100% so pleased with that (heading tin the right direction hopefully). Earlier I enjoyed the #MB1031 lecture on how to improve our report as I found I'm doin all the calculations correctly, though I need to improve my written content later today. Off now to the #BS1009 lecture on BIOTECHNOLOGY. Can't wait as I'm already interested in this area but it should, moreover, help with writing the module essay on microbe use.
- Max Levin
The #BS1011 work this week was a little more challenging but luckily excel isn't actually the worst thing ever as with a little exploration and intuitive thinking most things become self explanatory. Last week’s #MB1005 practical was a step up too and I struggled with some of the concepts dealt with so need to read over the lecture notes to give myself a clearer understanding. I’m a little bit apprehensive about writing the report for #MB1031 as I’m quite slow at written pieces. At least I know what I’ll be doing this weekend.
- Max Levin
Good first week and good start to this week. I've done all my short-term compulsory work, I just need to start the #BS1009 module essay as I have only briefly researched it so far. I also need to make notes on lectures by combining my lecture notes and the blackboard notes, a technique that served me well last semester. Off now to read over tomorrow's #BS1009 practical.
- Max Levin
I have answered all the questions for the first #BS1011Excel assessment and all my formulae work but I'm afraid to submit the answers incase they're not in the most simple form. I can't see how I can simplify any of them but also I haven't used excell in along time and, for the most part, I've never used the formula before. Should I just submit?
Pages like this provide a useful base of information (esp. paragraph 6 and below) that can be expanded upon later. I will research the topics mentioned in more detail, particularly the use of biotechnology in vaccines for use in the #BS1009 module essay entitled 'How would you convince a friend that microorganisms are more than just disease causing agents?'.
- Max Levin
from Bookmarklet
Over the past month I've been working pretty hard so it was good to have a break at the end of last week, although mine was late starting as I had to give my #MB1030 presentation to Dr Willmott on thursday morning when everyone else was probably in bed. Looking forward to the new semester and I have better attitude already, so I should be more focused. I thought the #BS1009 lecture today gave a good overview microbiology and, as I'm already interested in biotechnology, I'm sure I'll enjoy the module!
- Max Levin
Are the words topoisomerase and gyrase interchangable or is gyrase a type of topoisomerase or what?
topoisomerase II is also known as DNA Gyrase whereas i believe this differs from topoisomerase I which has a different function.
- Arnold Gangaidzo
Topoisomerase I catalyses the relaxing of super coiled DNA whereas DNA gyrase (topoisomerase II) utilises free energy from ATP hydrolysis to add negative supercoils to DNA. Type I does this by cleaving one strand of DNA whereas type II will cleave both strands. Read Stryers pg. 790. Thanks for the post...got me recapping!
- Arnold Gangaidzo
Gyrase is a bacterial example of a type II topoisomerase (topos). Type II topos cut both strands of the DNA whereas type I cut only one. There are other type II topos, for example another bacterial one called Topo IV. There are eukaryotic type II topos too (sufficiently different not to be affected by the same antibiotics). So gyrase is an example of a type II topoisomerase #BS1015
- Dr Chris Willmott
Does the fact that blackboard has been down over the weekend mean we wont be penalised for only just submitting our last #BS1010 assessment? - technically we haven't had 7 days yet (~6 by my reckonings).
162.5/200 for #BS1015 practical exam. Standard. Merry Xmas everyone, you've earned it. Probably. (You've probably earned it doesn't sound as good though :p)
Translates literally into modern English as 'lots of excited'. A more appropriate translation would probably be 'very happy'. He got 21. Well done Max :)
- Christopher Lysons
thanks Christopher! And congrats 2 u Max, that is something to be v happy about!
- Maryam
Thanks guys, esp. Chris for translating! :)
- Max Levin
When you are given only the equilibrium constant and initial conc. of reactants, how do you find the equilibrium conc. of product?
Most of you have probably already noticed but, slide 10/22 in Dr. Evans' #CH1070 Advanced Kinetics 1 lecture is a great collection/comparision of the formulae needed in kinetics. :)
Is having something similar to fun by condensing the #CH1070 lecture slides to his own notes. Just leaving the important bit in my own words makes it all more managable and a bit less daunting.
If your not fully satisfied (although you should be) i suggest you get a friend to proof read the essay before you hand it in. Its an effective technique that will bump your grade to that 1st your aiming for.
- Munaf khamisa