same all over the place(judging on swiss, germany and US)! hopefully it will change provided the shift to "science 2.0" and stuff that comes along - Yaroslav
Here is another angle. How many chemical engineers do you know who stay in chemical engineering afterwards? The difference is that scientists usually really care about the science, so it's more of a bummer. - Deepak
I think Science 2.0 is one the main reasons I'd stay and do a post doc. Apparently it's just at the end of this rainbow here, just need to a walk a little bit further... - Michael Barton
I've been *doing* Science 2.0 and I'm beginning to look for the escape hatch - my funding's up in December... - Andrew Walkingshaw
Each day I'm more and more convinced that Science 2.0 is not about changing the system - it's about changing the scientists themselves. In this spirit I hope the S2.0 movement will help me grow so I can take care of my research by myself. I stopped counting on the system already some time ago. - Pawel Szczesny
imho, changing researcher ideology/attitude is not sufficient - in the limit, one cannot work simply on enthusiasm...we really need to change the system to be able to get resources for our work - Yaroslav
I think early stage researchers are those most likely to try Science 2.0 in their research. At the same time though, the earlier you are in your career, the less funding and freedom you have to purse Science 2.0. - Michael Barton
I think i agree with Pawel here. 'S2.0' actually makes things tougher for young scientists in some ways. It suggests that you need to change the way you approach science, and implies in many ways the kind of 'going it alone' that Pawel has blogged about. As a young scientists you actually have more freedom in how and what you do but less resources to express that. At the end of the day, something has to pay for the groceries, and that is the core problem. - Cameron Neylon
before tenure make sure you check off all the other boxes before Science 2.0 - Jean-Claude Bradley
There's a load of informatics/science 2.0 types looking, or who will be looking, for new jobs in the UK after the (effective) drying up of eScience funding. Mind you, the STFC debacle's hitting everyone's funding, so at least we're not being singled out... - Andrew Walkingshaw
Its worse than just the STFC problem. The government spending settlment across the research councils plus the final push to full economic costing means that the volume of PDRA/PhD funding will be down right across the spectrum, except for MRC. I would suggest going into medical statistics and translational medicine for the next few years. And who knows what will happen after the RAE - Cameron Neylon
Agreed, funding competition is incredible tough in the UK and the US. I post doc'd on a couple of "2.0" projects at Cornell that had to be parked: demotivating at best. - Matt Wood
Seems to do quite a lot of what you would want it to do. Can only have up to 20 attendees in the free version but that's not bad and its open source - Cameron Neylon
“My next project is to see if cost is a factor in the evolution of genes in yeast. I'll start by using CODEML on sensu strictu orthologs.”
April 28 at 9:18 am
Could you elaborate on that ? :) Do you mean protein evolution, duplication , .. ? I would guess that most of the selection pressure for codon/amino-acid preferences come from translational robustness pressures. - Pedro Beltrao
Yes, sorry that was a bit vague. I'll write a blog post soon to out line the project aims. - Michael Barton via Alert Thingy
I'm going to align yeast genes, get sitewise mutation rate then see if the cost of the amino acid at the position correlates with mutation rate - Michael Barton via Alert Thingy
The theory being that biosynthetically expensive amino acids are highly converved as otherwise they would be selected out in favour of cheaper ones - Michael Barton via Alert Thingy
I'm still learning the molecular biology of evolution, so feel free to point any glaring errors in this - Michael Barton via Alert Thingy
I think we'll look at AA's inside and outside domains, as well as controlling for different expression levels in S.cerevisiae - Michael Barton via Alert Thingy
You probably know this one already (http://mbe.oxfordjournals.org/...). It is a good place to start if you want to measure to what extent amino acid costs are a factor in determining the rate of protein evolution. - Pedro Beltrao
