Ruthenium-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Aryl and Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes - http://pubs.acs.org/doi...
Cyclization via Pictet-Spengler reaction gave diastereo-enriched dihydroisoquinolines which can be separated and converted to the enantiopure product
- Michael Wolfle
A general approach to architecturally stimulating polycyclic structures is described by a concise, two-step procedure including a Ugi MCR (multicomponent reaction) and a subsequent Pictet−Spengler reaction starting from phenylethylamine-derived isocyanides...
- Michael Wolfle
Schistosoma mansoni Infections in Young Children: When Are Schistosome Antigens in Urine, Eggs in Stool and Antibodies to Eggs First Detectable? - http://www.plosntds.org/article...
Up to 50% of young children were clearly shown to have schistosomiasis and could likely wait up to 3–4 years before obtaining first treatment if present de-worming policies are not changed.
- Michael Wolfle
Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity - T. Umemoto et al. - JACS - http://dx.doi.org/10...
Bifunctional Organocatalyst for Activation of Carbon Dioxide and Epoxide To Produce Cyclic Carbonate: Betaine as a New Catalytic Motif - Takashi Sakai, Org. Lett. - http://pubs.acs.org/doi...