"Yep. Which is why on European trips, when possible I travel by train. More efficient, more comfortable and on the right routes, you get to enjoy some good scenery too. I miss trains in the US, both for local transit and long distance travel. I don't mind flying, and I fly crazy amounts, but it's become increasingly difficult to justify the headache, especially for some of the shorter fly-in, fly-out trips that I take"
- Deepak Singh
Good, but very basic. Looks like they're just trying to bring standard OSS techniques to bioinformatics.
- Donnie Berkholz
It is basic, but you'll be surprised how little of that happens.
- Deepak Singh
I think publishing these very basic guides is "A Good Thing" - but I don't know that bioinformatics/computational biology journals is the right place. The readership of those journals tends to be those who find the information too basic. Might be better to publish such material in biological science journals - Nature Biotech, for example, runs a very good introductory maths/stats/computing series.
- Neil Saunders
"KINGSTON, Jamaica (AP) - An American Airlines flight carrying 154 people skidded across a Jamaican runway in heavy rain, bouncing across the tarmac and injuring more than 40 people before it stopped just short of the Caribbean Sea, officials and witnesses said. Panicked passengers screamed and baggage burst from overhead bins as Flight 331 from Miami careened down the runway in the capital, Kingston, on Tuesday night, one passenger said. The impact cracked open the fuselage, crushed the left landing gear and separated both engines from the Boeing 737-800, airline spokesman Tim Smith said."
- bob
from Bookmarklet
It has winglets, doesn't seem all that old to me. Planes just aren't designed to land like that one did.
- Alex Scoble
I heard on CNN that the passengers were clapping at the smooth landing before the accident. This runway has poor drainage, so the plane's brakes may have been ineffective. The bouncing and damage may have happened after it left the tarmac. I don't know whether the report I heard or this article (citing turbulence) is accurate. Wait for RISKS Digest.
- Bruce Lewis
from fftogo
And the break pattern seems consistent with the nose, fuselang and tail being separate components
- Deepak Singh
Roberto: The 737-800 has only been around since 1997, so the plane couldn't be more than 12 years old.
- Gabe
See http://www.maxtrescott.com/max_tre... for an AFAICT purely speculative suggestion of what may have happened. Anyway the simplest explanation now is that it broke up because it ran off the runway. Why did it run off the runway? Good question.
- Daniel Dulitz
Running off the end of an 8700 foot runway takes more than one or two factors...
- Daniel Dulitz
Ok not so old then. I wonder what the crash investigation will turn up.
- Roberto Bonini
from iPhone
On CNN a pilot said that this runway lacks grooves for drainage. Hydroplaning and the tailwind are two factors. We'll have to see what other factors were involved.
- Bruce Lewis
"I've wasted 2 months of distributed computing time on just bad assumptions made by mistakes I made, so as noted below, in the big picture, that's a relatively minor loss. Does it set back science. Of course, but is it catastrophic, no. As someone pointed out above, in fields where you collection and analysis times are measured in years if not decades you could run into trouble, but for chemistry and biology where you are at significantly shorter collection timescales, it isn't that big of an issie"
- Deepak Singh
"I have an Ableton driven studio with oodles of softsynths. I'd say the difference is a factor of 10 at the least even with higher end software. What you do end up spending on is some of the hardware you can't avoid (quality audio interfaces, reverb units, controllers)."
- Deepak Singh
The BWA/SAMtools separation is great. Other aligners like Bowtie are now producing SAM as well, so you can swap aligners in and out of analysis pipelines a little more freely. Absolutely the right direction to go.
- Brad Chapman
Brad, that's great. I was a little concerned about the "use this aligner for this pipeline" model
- Deepak Singh
he following set of guidelines distill several key principals of effective bioinformatics programming, which the authors learned through insights gained across many years of combined experience developing popular bioinformatics software applications and database systems in both academic and commercial settings
- Deepak Singh
This blog post is rather rough and ready - a work in progress - but I wanted to push it out before the holidays. Find out which items from this group in 2009 were most discussed (comments/likes)!
- Neil Saunders
hey, good stuff: especially like the healthy diversity concerning the contributors of most commented/liked entries, do you happen to have a little stat on the most frequent contributors in terms of number of entries, likes, comments or all of them?
- Attila Csordas
It's certainly easy to calculate per user contributions using the API data, but I haven't done it. Might be fun, but I'm more interested in what's discussed than who posts. Feel free to adapt my code!
- Neil Saunders
what's the license for the code, and is there a way to download it other that copy+paste? looks cool, thanks for sharing!
- Mike Chelen
Licence is "it's on my blog, you can copy it and do what you want" :-)
- Neil Saunders
It means I don't take licencing of my posts very seriously :-) Although now I look closely at my blog, the relevant icon is top-right, just above the search box.
- Neil Saunders
although NC and SA clauses are a bit restrictive, it is fine for the time being. since the code is useful, giving licensing some consideration may be worthwhile :)
- Mike Chelen
If it were actual code for download, I'd think about it more. When it's text on an open, public web page, I just assume people will do with it what they will. Anything goes, except claiming that you wrote it :-)
- Neil Saunders
copyright law prohibits duplication without your consent, regardless of whether it is on a website or in a repository. while some may break these laws, many of us are committed to working within its boundaries through the use of open-source licenses :)
- Mike Chelen
I'm intrigued that things are so spread out - no one person has more than one entry in the top 10 list...good sign of collaborative effort IMO
- Cameron Neylon
Facebook acquired FriendFeed on August 10. Am I right that there is no significant change in number of posts over the year or after the acquisition?
- Martin Fenner
This is really cool Neil. When I saw readI immediately though if this could be done on a rolling monthly basis this could be the new version of BioBlogs. Maybe some sort of simple Sinatra app.
- Michael Barton
Sample sinatra app on Github and hosted on Heroku :)?
- Deepak Singh
Neil, I agree w/ you: most commented/liked entries are more interesting than the list of most frequent contributors (although that is interesting nevertheless)
- Attila Csordas
I like the idea of automated monthly analysis as a web app! Tricky bit will be fetching only new entries and not missing any, but once a db structure is in place, shouldn't be too hard. I'll give that some serious thought.
- Neil Saunders
"Exactly. And that's often how fraud gets found. You are trying to build on someones research and some of the assumptions aren't working or you can't baseline the work. That usually leads to trying to reproduce the original work and voila ... fraud at the worst (I'd say most of the time it's just sloppy work)"
- Deepak Singh
tl;dr. But I printed it out to read on my commute! :-)
- Bill Hooker
I printed it off too and read page 1 of 27 on my commute (which is only 6 minutes). Will read the rest on a longer journey !!!
- Graham Steel
Six minutes? Mine's 1.5 - 2 hours, depending on which train/bus combination I take (the faster route is only operational at certain times of day). It's not so bad if I remember to bring reading material.
- Bill Hooker
2 hours! Even this post can be read in less than that!
- Bora Zivkovic
Bill, my commute ranges from about 1-1.5 hrs, depending on the traffic. It can be longer in bad weather or the insane crush weeks at the start of each school term. At two hours, you're a prime candidate for an ebook reader!
- John Dupuis
John just pulled the words from my fingers. Anything over 45 minutes screams for one.
- Deepak Singh
You know your commute is too long when you can read an entire Bora Epic in one trip... if the Kindle DX were not ridiculously expensive I'd already have one. Most of my reading is pdfs (spit!) so I do not want the regular Kindle, but I will get to try it out since my wife just got one.
- Bill Hooker
Ooh, nice. Thanks for pointing that out, Deepak. I still think the screen will be too small for comfort, but we'll see... would it make me a bad person if I stole my wife's Xmas present? :-)
- Bill Hooker
I've read a Kindle2 for hours (albeit mostly all books) and it was always stolen ;)
- Deepak Singh
from IM
Avro is a data serialization system. Avro provides: * Rich data structures. * A compact, fast, binary data format. * A container file, to store persistent data. * Remote procedure call (RPC). * Simple integration with dynamic languages. Code generation is not required to read or write data files nor to use or implement RPC protocols. Code generation as an optional optimization, only worth implementing for statically typed languages.
- Deepak Singh
"When I joined my group pretty much everyone was either using a blackberry (the majority) or Windows Mobile phones. Today the majority are iPhones. Thats for a group that has grown a lot since then too, so one could easily argue that the other manufacturers (at least Apple) are making inroads into the business phone market without the need to make dedicated devices."
- Deepak Singh
I'm like the author of the article, but sometimes I wonder if I would be better off being the other way.
- Ruchira S. Datta
I don't see the need to make value judgements. Some people get deeply into a narrow field, some people cross-pollinate; both "styles" have their strengths and uses.
- Bill Hooker
Some of us are into science, even if we aren't practicing it, so generalizations are difficult. But I do think our system is at a crossroads. People who are passionate about science don't always have avenues for that passion, or at least think they don't
- Deepak Singh
Publish - no; read -- well, I skim it every year. More often I use the summary info to gauge how the datapile is growing.
- Bill Hooker
I read it every year in growing amazement; how can so many databases be sustained? I guess the answer is they can't. There does however seem to be a low dropout rate over the years... but I realise I've not yet read this years' issue, so maybe that tells a different story.
- Chris Rusbridge
Publish - yes (thanks to Andrew Su). Read : only the "big" ones (NCBI, etc... )
- Pierre Lindenbaum
it's not something I sit down and read cover-to-cover, but google searches often take me there on a semi-frequent basis for tools that sound relevant to my needs...
- Andrew Su
Chris, I doubt many can be sustained over a period and that's a big problem with how we fund infrastructure.
- Deepak Singh
I think I disagree a bit with Deepak on this point. I agree that many can't be sustained, but I don't think that's a problem at all. IMHO, put the tool out there, publicize it as widely as you can (and the NAR DB issue creates a great baseline playing field), and let's see how well it's used. Then it's up to the funding agencies to evaluate usage/impact (which understood, isn't an easy thing), and fund the best ones.
- Andrew Su
Andrew, that's fine, but the way we fund infrastructure is broken cause we don't appreciate it. Nothing wrong with doing something, but even if useful, there is no guarantee it's going to be funded appropriately (the correct kinds of resources).
- Deepak Singh
Plus, I think half these databases exist just for the goal of paper generation. Maybe I am being too cynical but if not half, some non-insignificant number
- Deepak Singh
Deepak, definitely agree with your second comment...
- Andrew Su
Deepak, I also completely agree with your second comment.
- Lars Juhl Jensen
I have mixed feelings about the database + web issues. It's exactly the type of content that I think is unsuited to journal article format. The resources themselves should be valued, rather than their dry, dull, traditional and rapidly-obsolete descriptions. On the other hand, in a world where merit is measured by publication, how else are bioinformaticians to gain attention? :-) If you can get it together once a year, it amounts to a free publication opportunity.
- Neil Saunders
Indeed Neil. I think that there is no doubt that the NAR database issue fulfills a need. However, the problem is in my opinion that this need exists in the first place. If you have made a good database or web resource, you should get credit for that without necessarily publishing a paper about it.
- Lars Juhl Jensen
Sarah Palin kicked out of hospital fundraiser in Canada. Palin has said that "Canada needs to dismantle its public health-care system and allow private enterprise to get involved and turn a profit" - http://www.reddit.com/r...
It's amazing how some US citizens can be so blind to not see where market economy fails... free market requires buyers to be able to decide, "no, perhaps when you lower your price..." But it just does not work like that for health care... or housing... there does not exist something like a free market when basic needs are involved...
- Egon Willighagen
health care, housing: these are 'constrainted' markets... you just can't decide, no, let's not have a new kidney this year and wait until the market is better... no, let's use boxes this year until the house prizes have dropped a bit again...
- Egon Willighagen
Egon, you have put your finger on the worst thing about the US (imo, as a recent immigrant). It's not so much that citizens are so blind as that the kleptocracy in power understands your point completely, and completely does not care. Government of the people, by the rich, for the rich... I just hope for the revolution to be a "velvet" one when it comes.
- Bill Hooker
@Egon, I'm hardly an expert on policy issues, so I don't pretend to necessarily know best, but market failure doesn't necessarily mean a non-market solution is best; if anything it suggests that the focus should be in finding a way to establish a competitive market as to prevent a government from having too much influence over private citizens. Some ideas that I'd like to see evaluated...
more...
- Benjamin Tseng
Problem is that consumers lack the specialized skill to properly evaluate health care choices that means an expert ie The Gov must mediate the choices and provide regulations to preent the consumer from being unwitting victim same as they license doctors and lawters they must regulate teh healthcare indistry
- WarLord
"given that the American system "works" broadly speaking" -- that stretches "broadly" to breaking point imo. Have you ever "been without health insurance" (honest term, "failed to pay the required protection money") in the US?
- Bill Hooker
@Bill, I'm not going to pretend the American system is perfect (b/c it isn't), but almost all employed people in the US have healthcare that they are satisfied enough with such that they're not willing to take their chances on a public option; that doesn't mean I condone the failings of it with regards to access or equity, nor does it mean I wouldn't experience hardship if I lost my job...
more...
- Benjamin Tseng
@Benjamin, fair enough -- I can't pretend to be a policy or market expert either. I am also not exactly an impartial observer, being for the moment without health insurance in the US! (I spent my first 30 years in Australia, so my experience of a public option is that it has its problems too, but nothing like the massive systemic failures of the US system in its current form.)
- Bill Hooker
@Bill, I'm sorry to hear that :(. Does your employer not provide coverage? I thought you were at a biotech firm?
- Benjamin Tseng
"When there's a problem with your car engine, you fix the engine, you don't necessarily replace the whole car" Unless the engine was damaged because another part of the car is malfunctioning due to being poorly laid out. Many people can't switch coverage because of "pre-existing conditions" even though their current insurance is severely lacking in coverage and customer service. The...
more...
- Heather
Benjamin, I can point to a specific example (and I have always been covered and found the US system substandard). When you go to the ER, you could get billed the full amount for an emergency procedure, just because the doctor you saw wasn't contracted with your insurance company at that particular ER. Last I checked, when you go to the ER for an emergency procedure that's not what you...
more...
- Deepak Singh
@Benjamin -- we're working on it. I should have said "temporarily" or similar. Can't explain in detail -- public company disclosure blah blah blah. Suffice to say I'm not being exploited, and didn't want to give that impression!
- Bill Hooker