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Victor Ganata
Increasing time between eating controls metabolism and reverses obesity in mice - PRI
"When you feed mice a high fat diet, they like to eat that food all the time. They eat it during the nighttime and during the daytime. Instead of getting a good day's sleep, they tend to eat the food." - Victor Ganata
Sounds like two meals a day is a good plan? - Todd Hoff
(As an aside, I worked with Dr. Zarrinpar when he was a med student and I was a resident at UCSD :D ) - Victor Ganata
What about "grazing" on six tiny meals a day, nutritionists!!?!?? I feel betrayed. - Andrew C (✔)
That was last week Andrew. - Todd Hoff
Bear in mind this was done with high-fat diets (and also with high-carb and specifically high-fructose diets.) It would be interesting to see if the effect is all that pronounced when you feed mice more balanced diets. The changes in gene expression and in the gut microbiome won't be instantaneous, either, so you'll most likely feel like you're starving in the beginning. - Victor Ganata
Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome - Cell - 2014 Dec 2 - the paper focuses mostly on the changes to the gut microbiome - Victor Ganata
"Obese humans and mice have gut microbiomes that are different from their lean controls. In particular, obesity is associated with a reduction in bacteria from the Bacteroidetes phylum and an increase in bacteria from the Firmicutes phylum. Metagenomic analysis of the obese microflora shows that it is enriched for genes associated with lipid and carbohydrate metabolism." - Victor Ganata
"Mice with ad libitum access to normal chow have a cyclical feeding pattern, eating most of their diet during their nighttime active phase and less during their daytime inactive phase…. Mice that have ad libitum access to [a high fat diet] spread their caloric intake, feeding during the dark/active phase and the light/inactive phase." Basically, eating a high fat diet makes you want to eat all the time even when you should be sleeping (at least, if you're a mouse.) - Victor Ganata
OTOH, if you can successfully restrict how often you eat, then the changes a high-fat diet will cause in your gut microbiome won't be deleterious (at least if you're a mouse.) - Victor Ganata
On a ketogenic diet it's pretty easy just to eat once or twice a day, so that may be part its success. - Todd Hoff
A ketogenic diet probably causes a whole other set of changes to the gut microbiome, though. I guess it is kind of misleading to say that it's merely about changing frequency of eating. What the paper actually points out is that switching to a high-fat diet causes deleterious changes in the gut microbiome, but restricting frequency of eating completely mitigates those changes (although... more... - Victor Ganata
Your gut critters will adapt to whatever you eat, so I'm not sure why that is at issue. - Todd Hoff
Why it's an issue is because certain gut critters cause people to gain weight and make them more likely to develop diabetes and heart disease. - Victor Ganata from iPhone
Yes, but saying there's adaption to diet doesn't really help figure that out because there's always an adaptation. And what I meant in a ketogenic diet is you really do feel less hungry so you have greater intervals between meals, which I've never heard attributed to why it may help people keep weight off. The issue is it's boring as hell. - Todd Hoff
Well, they did speciate the different bacteria and certain species are more associated with obesity and diabetes than others. - Victor Ganata from iPhone
Zulema ❧ spicy cocoa tart
Apparently I sent a coworker a message that I licked his work computer last night. Seriously??? Rum, why you do this to me? 🙈
Oh my. - SAM
It was probably salty. - Todd Hoff
Poidh. - Joe
Did you lick the computer last night? :P - (Curtis) Alan Jackson
That is not how you taste test the recipes on Tumblr, young lady. - Steven Perez from Android
Don't feel too bad, Z. I drunkenly danced with some dude named Ole and literally crawled into the apartment last night. I don't even know what I was drinking last night. - Jenny H. from Android
Mark Trapp
Took a while, but I finally finished my write-up of Brandopoly, the thing I was working on for almost a decade:
Took a while, but I finally finished my write-up of Brandopoly, the thing I was working on for almost a decade:
Wow, really interesting - thanks for writing that up, Mark. - Micah from FFHound(roid)!
Thanks for checking it out! Been weird to write about something that close to the chest for so long. - Mark Trapp
Wife apparently trying to pull an all-nighter to get 5 more felt ornaments done so my son can give them to his classmates as gifts for his birthday.
Those are wonderful! - Anne Bouey
Unfortunately couldn't finish in time but we'll probably take them in sometime next week as holiday gifts. - rönin
So cute! - Tamara J. B. from FFHound(roid)!
They're super cute! - Starmama from FFHound(roid)!
Zulema ❧ spicy cocoa tart
Rum is good to me. Vodka hangovers are like having the flu, man. Ain't nobody got time for that!
hmm, I don't really drink anymore (alcohol in general irritates my stomach) But, back when I did, I don't think I ever experienced a Vodka hangover. Now, a Tequila hangover? Man, that mess nearly gave me PTSD. I may be the only Mexican who has banned Tequila from her home. - AHnix (Anna Haro)
interesting. I'm a bit opposite. rum will ruin me for days while vodka just kinda evaporates. tequila, yeah, only under strict supervision and followed by days of doing nothing. whiskey is a 50/50 chance of regretful headache. - t-ra supports #LOLSpidra
I heard on NPR there is no difference between different boozes and their hangover effects. It's all about quantity, hydration levels etc. Though experientially it's possible to have pretty similar circumstances around imbibing in certain spirits, which gives the impression of different hangovers. - SAM
^Lies. SAM, stop spreading your commie-pinko propaganda. - AHnix (Anna Haro)
for real. whomever is stating such falsehoods on public radio has never had too much mezcal. - t-ra supports #LOLSpidra
Man, vodka messes me up bad. Gin too. But tequila, rum, brandy, and any liqueur are cool with me. I haven't tried scotch or whiskey so that's next on the list. - Zulema ❧ spicy cocoa tart from Android
Intoxication With Bourbon Versus Vodka: Effects on Hangover, Sleep, and Next-Day Neurocognitive Performance in Young Adults - Alcoholism: Clinical and Experimental Research - 2009 Dec 17 "Beverage congeners in bourbon versus vodka did significantly increase the intensity of hangover that was felt, consistent with results from studies in the 1970s." ;) - Victor Ganata
Why the ‘Coffee’ Words Are Not Cognates - Languages Of The World | Languages Of The World -
Why the ‘Coffee’ Words Are Not Cognates - Languages Of The World | Languages Of The World
"A former student of mine drew my attention to a recent article in Slate written by Alyssa Pelish and titled “The Stimulating History of Coffee: Why You Hear This Word Around the World” (the image on the left is reproduced from the article). Pelish starts with a little thought-experiment about how one would order a coffee while travelling around the world: Kaffee in Berlin, caffè in Rome, kofi in Lagos, Nigeria, kŏfī in Delhi, India, and кофе (pronounced /’kofè/) in St. Petersburg, Russia. She correctly points out that these words sound alike in many languages, describing these words very poetically as “the two reliable syllables, the seesaw of vowel sounds punctuated by velar stops and fricatives”. I am not sure about the reliability of syllables or how one would go about measuring it, or whether the alternating consonant-vowel-consonant-vowel (CVCV) pattern can be called a “seesaw”. But the explanation Pelish provides for why these ‘coffee’ words are so similar the world over is entirely wrong and ignorant." - Maitani from Bookmarklet
Interesting idea. Jynnan tonix all round while we discuss. - David Lounsbury from iPhone
haha :) - oKoman
Hatırlamayan bizden deyıldır. :) - N/A
geçmişe bir saygı duruşu olmuş :)) - Bülent Kıyışkan daha iyisini yapmışım. :) - N/A
Yeşil yazan webmaster sen mi oluyore? :)) - Bülent Kıyışkan
Heeee. - N/A yok aslında hiç fena deyilmiş yaptıklarım. Hiç bu çarka girmedim yani. :) - N/A hatta halen fena sayılmıcak işlerimiz de varmış. :) - N/A
Bu da benim ilk yaptığım site: - Bülent Kıyışkan
2002 yakın bi tarih. :) - N/A 2000'de yapmıştım. Hemi de dinamik. :) Millet phpBB vs. kullanırken biz kendi forumumuzu yazıyorduk. :) - N/A şimdiki halinden çok daha iyimiş :) - GeNoM
Jonathan Bernier mistakenly praises Mandela's hockey skills - NHL on CBC Sports - Hockey news, opinion, scores, stats, standings -
Jonathan Bernier mistakenly praises Mandela's hockey skills - NHL on CBC Sports - Hockey news, opinion, scores, stats, standings
"The Toronto Raptors paid tribute to Mandela on the anniversary of his death. Unfortunately, Bernier wasn't aware of the honouree's significance beyond his apparent ice hockey career prior to attending the event. The Toronto Star reported that the 26-year-old Laval native apologized for his mistake." - Eivind from Bookmarklet
:)) - Shirinooo
Işık Mater
Andrew C (✔)
Yarrrrr, tiny lizard in my kitchen just now. (the squares are 4" a side, to give a sense of scale.) I managed to coax it into a cardboard box, and then I dumped it back outside.
Aww. - Jenny H. from Android
For me, more like ewwww. - Andrew C (✔)
Spidra Webster
BBC News - First Bus wins wheelchair court judgement -
BBC News - First Bus wins wheelchair court judgement
"Bus companies are not required by law to force parents with buggies to make way for wheelchair users in designated bays on vehicles, senior judges ruled. First Bus appealed against a court ruling, won by a disabled man from West Yorkshire, that the firm's wheelchair policy was discriminatory. Doug Paulley, 36, was denied access to a First bus to Leeds when a woman with a pushchair refused to move. The Court of Appeal overturned a Leeds County Court judgement in his favour. 'Request not require' Mr Paulley had attempted to board the bus in Wetherby to visit his parents in Leeds in February 2012. But he was told to wait for another one when the woman with the pushchair refused to move because her baby was asleep. First's policy was one of "requesting but not requiring" non-disabled travellers, including those with babies and pushchairs, to vacate space needed by a wheelchair user. In September, a county court judge said the firm's policy was in breach of the Equality Act 2010. Mr... more... - Spidra Webster from Bookmarklet
Wow even in the heart of the hood I've never seen anyone refuse to move for a wheelchair. Even moms with strollers. Okay, it's requested but not required. Still, what's wrong with that lady? - Starmama from FFHound(roid)!
Same here, Starmama. In fact bus riders will call out "Wheelchair comin'" and folks will get up from the wheelchair bench and even help the driver convert it to a wheelchair slot. - m9m, Crone of FriendFeed
It really boggles my mind. - Spidra Webster
Steve C Team Marina
After traveling 3 straight weeks for work i'm taking tomorrow off. You know what that means. Say it with me: red wine and puffy cheetos tonight!
Style: You have it in buckets. Buckets of wine, and buckets of cheesy puffs! - WoH: Professor MOTHRA
Please to be publishing photo of your purple and orange stained lips. - Spidra Webster
class all the way - MoTO: #TeamMarina
No M&Ms? I'm disappointed in you, Steve. - Tamara J. B.
Big Joe Silence
it frightens me a little (in a good way) how our youngest rips straight through her maths homework seemingly effortlessly and when we check it she's nailed every problem.
Melly Claus #anticaper
RT @timcashmere: Ping @katreeeena and @FelicityCull. RT @erinfaye: They knew how to make library rules in 1930."
RT @timcashmere: Ping @katreeeena and @FelicityCull. RT @erinfaye: They knew how to make library rules in 1930."
holly #ravingfangirl
'Fewer' Or 'Less?' The Express Lane Language Debate : NPR -
'Fewer' Or 'Less?' The Express Lane Language Debate : NPR
"You're ready to check out at the supermarket. There are only eight items in your cart, so you look for the express lane. The sign above says "10 items or less." Do you: — Head for the register without a second thought? — Rue the decline of the English language because you were taught that the sign should say "10 items or fewer?"" - Maitani from Bookmarklet
"This week's "Word Matters" conversation with Weekend Edition host Scott Simon explores the "less vs. fewer" debate." - Maitani
Rue. - bentley
^LOL - Eivind from Android
Both of the above choices. - m9m, Crone of FriendFeed
I'd do either, but mentally congratulate the store that uses "fewer." - Walt Crawford
Often times, the express lane takes longer... typical human conundrum. - Adriano
Steven Perez
So, of course, after climbing wet rocks at the seashore, I twist my ankle getting into the Mini. Oh, yeah, my ninja skills are awesome.
I applied ye Olde Tiger Balm, so it feels a little better now. Hopefully, I'll be able to tackle the trail in the morning. - Steven Perez from Android
Andrew C (✔)
RT @john_overholt: This.
RT @john_overholt: This.
Love - Meg VMeg from Android
I checked that thread out. There's a followup where some other rando says women like her should get CS degrees instead of complaining about gender imbalance; she replied that she went to engineering school. - Andrew C (✔)
I so adore how dumb of my fellow males can be. *smh* - (Curtis) Alan Jackson
Aw, he omitted the "I" and meant to say that he read the article. I'd almost feel bad for him if he'd have been more chagrined after the fact? As it stands, it doesn't look like he even understands what happened. He thinks people are making fun of him for a grammar error. Bless his heart. - Meg VMeg from Android
But no one mansplained it to him??? - Andrew C (✔) from Android
I think he does actually understand and is just being blase about it because these things happen on the internet and there's no point getting one's boxers in a twist when (seeing as how he's a guy so people are only laughing at him rather than sending death threats and such) it'll blow over in a few days. - Deborah Fitchett
holly #ravingfangirl
RT @dory: CHRISTMAS DRINKING GAME Place a Santa hat on the corner of your TV and every time someone wears it... DRINK
RT @dory: CHRISTMAS DRINKING GAME  Place a Santa hat on the corner of your TV and every time someone wears it... DRINK
I fear for my liver. But I love this. I guess we now have our Christmas drinking game sorted out! - Hookuh Tinypants
Brent Schaus
#SaturdayFF -- I kinda fear how folks on FF will perceive this one. I was a Royal Canadian Army Cadet from 12-18 years of age.
It was a way to get out of the house; it was free; back in the 80s, it was still seen as a "feeder" organization for the Canadian Armed Forces. I loved it. - Brent Schaus
Eventually it became more about learning to play the bagpipes, and being a cadet piper, but my initial reasons for joining were all because I was "army-barmy". - Brent Schaus
As a kid, I was a certified marksman with small- and large-bore rifles. - Brent Schaus
I was quite good with a map and compass, could build shelters, never got lost. Competed in "skill-at-arms" competitions. Came in 2nd province-wide out of 50-some teams. - Brent Schaus
Drill: I used to love it. Teaching and doing drill. Again, the competitions. The precision. Hell, even doing my uniform: the ironing and the shining of boots and brass. - Brent Schaus
I hated my high school experience. It was not a good fit at all. But on evenings and weekends, I felt at home with these other young army-barmy kids. - Brent Schaus
Our Commanding Officer had a relationship with the Juvenile courts (now Young Offenders). If there was a chance that the kid on the stand would go to juvenile hall, he'd cut a deal that'd let them join our cadet corps as a kind of community service. So, a whole lot of my friends at this time were delinquents lol - Brent Schaus
Hell, I was a delinquent too, but I had the protection of a cop father. I'm not proud of this fact. - Brent Schaus
I used to be so good at finding my way around the woods. I loved topographical maps, too. Declination and all that stuff. THAT's what I wanted to spend my time learning, as a teen. - Brent Schaus
It sounds great! You've listed a lot of the things I wished I could've done in Scouts, but I never got to be a Scout for Reasons. I'm glad you had something you liked on evenings and weekends. - bentley
Scouts and Reasons. Are girls allowed to be Scouts these days? I wonder how they justified continuing the sexism of Baden-Powell's time. Girls were able to join cadets in the 70s, I believe, but even that seems late. - Brent Schaus from iPhone
Unofficially, from the beginning; officially, since 1975: - Brent Schaus from iPhone
It was strange: there was such a Puritan approach to relations between boys and girls in cadets. They called it "fraternizing", and you could be sent home from camp, for example, for indulging. I think it was the influence of the Protestant Boys' Brigade. - Brent Schaus from iPhone
All I know is: so many of my earliest snogs were with female cadets. God bless 'em. - Brent Schaus from iPhone
It would've been Guide Scouts, in Peru, but for confusing reasons we didn't get a troop at school. My school had a Scout troop: at the time, this was boys only. My mom, who had been a Girl Scout/Mariner Scout in Indiana, had gone through leader training so she could start a troop for girls, but it fell through. At the time, I understood that it was for political reasons (my mom was... more... - bentley
holly #ravingfangirl
every time i see Yemen mentioned anywhere, all i can think of is "I'm going to Yemen!" a la Chandler. i am a terrible person.
15 Yemen Road, Yemen. - Kristin from iPhone
kristin gets me. - holly #ravingfangirl
and is also a terrible person. - holly #ravingfangirl
My husband had a friend who went to live in Yemen in the mid 1970's. She would write to him (at that time) how it was truly the armpit of the universe. - Janet
In all fairness, I had no idea what you were talking about at the time because I avoided the internet and news all day. That being said, yeah, I am probably still a terrible person. :P - Kristin
:D be like me, Kristin! - holly #ravingfangirl from iPhone
Oh, okay, fine! - Kristin
holly #ravingfangirl
I have apparently been forgiven for this morning's atrocities.
I have apparently been forgiven for this morning's atrocities.
what did you do to the kitty this morning?? - Sir Shuping is just sir
antibiotics - holly #ravingfangirl
(Curtis) Alan Jackson
And 16 hours is quickly becoming 18. Love when crap hits the fan at work on the day there's a gap in supervisor coverage.
DB, Lil LB's Dad
#SaturdayFF: When I double press the unlock button on my car's key fob the headlights flash as I walk up. Sometimes I pretend that my car (Sil) is really Kitt from Knight Rider and make the "Kitt Sound" in my head.
The girls have discovered the joy of bubble wrap. Pop...pop...pop... :)
A rite of passage. <3 - Tamara J. B. from FFHound(roid)!
So funny seeing Sarah doing her best but her thumb is too small to properly pop the bubbles. - Stephan from iPhone
How did Orion withstand temperatures twice the melting point of steel? Meet Molly White, the engineer who helped make it possible
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СЕКСИЗМ!!1 - Edge of the Morrow
^ это ты про что? что орайон, влетающий в атмосферу земли, немного напоминает сперматозоид? - ⓒⓔⓐ
^ СЕКСИЗМ! - Edge of the Morrow
Yeah, you have to try
.LAG liked that
O h dear God. How did I miss this? - MoTO: #TeamMarina
I should have cut him. - MoTO: #TeamMarina
This is lovely. - SAM
How the hell did I miss this. BWHAHAHAHAHAHA - Anika
HAHAHAHA - Spidra Webster
*Tebows* - Steele Lawman from Android
Zulema ❧ spicy cocoa tart
does he say anything? - ellbeecee
Zu, did you make that foxy stole? Or is it an etsy purchase? So cute. - AHnix (Anna Haro)
I knit it myself from a pattern in Woodland Knits. Thanks! :) - Zulema ❧ spicy cocoa tart from Android
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