Current Opinion in Structural Biology, Vol. 19, No. 3. (08 June 2009), pp. 312-320. You want to know how proteins do it? Take a walk in protein fold space. More often than not you will get a clue if not the answer. If you know what you are looking for and how to find it. In fact, there is more information than we can presently handle. Charting fold space and chasing its creatures has occupied us for the past decades. There is no end in sight. Manfred Sippl - Andrew Perry