Great discussion to initiate... I for one love Seesmic's desktop app, but loathe installing/updating on various computers... having a browser-based interface just makes more sense. And I love Chrome (and Firefox). But when I look at other screens such as the iPhone I have the opposite reaction - rich apps are preferable over their browser-based counterparts for various reasons (lack of offline data access being my big dealbreaker). So some apps are great in-browser and belong there, while others (Evernote is another) are great desktop apps. And a speculative plus for AIR, if AIR gains traction in the mobile space, then any AIR app would have quite the competitive advantage with their apps crossing display (mobile/desktop) boundaries with a single rich implementation... - Sean O'Brien from FriendFeed MT Plugin

I don't agree with this post. Particularly for me the lack of the same-origin restriction for AJAX request is more than enough reason for using AIR. I'd like to stress the fact that the web version of seesmic doesn't have the Facebook integration that the desktop version has. - Marcelo Sanchez Gonzalez from FriendFeed MT Plugin