No, but will do so now... thanx for the pointer! (others: more ṕointer always welcome) - Egon Willighagen

Hate to be a pedant, but do you mean that a less thermodynamically favourable tautomer of a drug is the bound/active form? - Matthew Todd

@Matthew: our group is writing a book on pharmaceutical bioinformatics (cheminformatics, QSAR, proteochemometrics), and we are trying to have all examples pharmaceutically relevant... tautomerism is a source of variance in cheminformatics (as is pKa, resonance structures, conformations, ...), so discussed in the book... any effect of tautomerism on drug activity would be good enough - Egon Willighagen

@Neil you got a DOI? Your PubMed page does not link anywhere at uu.se and Google Scholar does not give hits on the title other than PubMed... - Egon Willighagen

PDF would do fine too of course... first.lastname _at_ gmail :) - Egon Willighagen

Ah, sorry... did not realize it was a book :( - Egon Willighagen