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Direct oxidative phosphonylation of amines under metal-free conditions, http://www.sciencedirect.com/science...
Althea Tsang liked this
Functionally Diverse Nucleophilic Trapping of Iminium Intermediates Generated Utilizing Visible Light, http://pubs.acs.org/doi...
All in one!
- Ahamed
Catalytic Asymmetric Activation of a C sp 3[BOND]H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives - Zhang - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Ahamed liked this
"10.1002/anie.201105123" Combination of Cu and DDQ, but not surprising given Li's example of a similar reaction with alkynes.
- Matthew Todd
from Bookmarklet
A Structurally Simple Self-Immolative Reagent That Provides Three Distinct, Simultaneous Responses per Detection Event, Scott T. Philips, http://pubs.acs.org/doi...
Enantioselective Boronate Additions to N-Acyl Quinoliniums Catalyzed by Tartaric Acid, http://pubs.acs.org/doi...
Old horse doing the trick.
- Ahamed
An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
"10.1039/C1CC15050B" Really?
- Matthew Todd
from Bookmarklet
Sometime back, i used V2O5, O2, in toluene to do alcohol oxidation. If i remember correctly R. A. Sheldon used this system in early 80's for various oxidations. The conditions are very old and well known, just two will-work-for-sure substrates. But cant be in Chem Commun.
- Ahamed
Homogeneous vs Heterogeneous Polymerization Catalysis Revealed by Single-Particle Fluorescence Microscopy
http://pubs.acs.org/doi...
Visible-light photoredox catalyzed oxidative Strecker reaction, Magnus Rueping http://pubs.rsc.org/en...
Matthew Todd liked this
Interesting - Althea it's the nucleophile you're trying to avoid. More evidence of N-Ar need.
- Matthew Todd
Total Synthesis of (+)-Yohimbine via an Enantioselective Organocatalytic Pictet–Spengler Reaction
http://pubs.acs.org/doi...
Michael Wolfle liked this
Peter Thiel launches Breakout Labs to fund bold early-stage research
http://gigaom.com/2011...
Matthew Todd liked this
Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Brønsted Acid Co-Catalyst - Hashimoto - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Michael Wolfle liked this
10.1002/anie.201104017 Another rxn on this ring system from Maruoka. Elaborate catalyst system and substrate but which delivers something challenging. One to reference.
- Matthew Todd
from Bookmarklet
Teasing one. Must have worked hard to optimize this one.
- Ahamed
Selective Catalytic C–H Alkylation of Alkenes with Alcohols. Science 2011, 333, 1613-1616. - http://www.sciencemag.org/content...
"10.1126/science.1208839" "Preliminary mechanistic studies are inconsistent with Friedel-Crafts–type electrophilic activation of the alcohols, suggesting instead a vinyl C–H activation pathway with opposite electronic polarization. " Soo. Any similarity?
- Matthew Todd
from Bookmarklet
Copper-Catalyzed Enantioselective Additions to Oxocarbenium Ions: Alkynylation of Isochroman Acetals
http://pubs.acs.org/doi...
Mary P. Watson did a 3 year postdoc with E. N. Jacobsen, so no wonder to see oxocarbenium ion chemistry.
- Ahamed
Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride, http://www.sciencedirect.com/science...
A Dual-Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition of O-Acylated Azlactones to Isoquinolines
http://pubs.acs.org/doi...
Our paper cited+again jacobsens chiral thiourea.
- Ahamed
A Mild Ligand-Free Iron-Catalyzed Liberation of Alcohols from Allylcarbonates, DOI: 10.1021/ol202270g
Reporter Protein-Targeted Probes for Magnetic Resonance Imaging
http://pubs.acs.org/doi...
Brønsted acid assisted activation of imide carbonyl group: regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine, http://pubs.rsc.org/en...
Construction of ISQ ring with different strategy. Possibility of generating chiral center at 1-position using chiral bronsted acid, a well known chemistry developed by Rueping.
- Ahamed
Don't see the novelty..?
- Matthew Todd
Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities - Chemical Reviews (ACS Publications) - http://pubs.acs.org/doi...
10.1021/cr100212h. Big Houk review. Nilupa.
- Matthew Todd
from Bookmarklet
Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules, http://pubs.rsc.org/en...
Mingfeng - how often are you checking this feed?
- Matthew Todd
Highly Efficient Synthesis of Polysubstituted 1,2-Dihydroquinolines via Tandem Reaction of α-Ketoesters and Arylamines Catalyzed by Indium Triflate,
ACS catalysis, http://pubs.acs.org/doi...
We have made substituted 1,2-dihydroisoquinolines at ease form ISQ.
- Ahamed
Unclicking the Click: Mechanically Facilitated 1,3-Dipolar Cycloreversions, DOI: 10.1126/science.1207934
Dont know how useful this is. Could be useful in targeted drug release, selective in vivo imaging.
- Ahamed
Just covered this in group meeting :)
- Matthew Todd
Already missing the group meetings.
- Ahamed
Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
10.1039/c1cc14185f
- Matthew Todd
from Bookmarklet
Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis - Rulli - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
10.1002/anie.201008042
- Matthew Todd
from Bookmarklet
An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS, http://pubs.acs.org/doi...
Matthew Todd liked this
Abstract: In 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalarial structures, we have identified 47 starting points for lead optimization. Their structures are provided. We invite potential collaborators to work with us to discover new clinical candidates.
- Ahamed
Indeed - ours is one of those series. Such a spectacular paper on so many levels.
- Matthew Todd
A New Synthetic Protocol for One-Pot Preparations of 5-Halo-1,4-disubstituted-1,2,3-triazoles Aus J Chem - http://www.publish.csiro.au/paper...
10.1071/CH11067
- Matthew Todd
from Bookmarklet
A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions
Science 9 September 2011:
Vol. 333 no. 6048 pp. 1423-1427
DOI: 10.1126/science.1207922
Matthew Todd liked this
Great, right?
- Matthew Todd
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