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Todd-Lab

Todd-Lab

Todd Lab at the School of Chemistry, Sydney
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Ahamed
Why is this Todd-Lab friendfeed page almost inactive from last 6 months? This is such a awesome way to share random science.
Ahamed
Organocatalytic Asymmetric 1,4-Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether http://pubs.acs.org/doi...
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Ahamed
A Comparative Mechanistic Study of Cu-Catalyzed Oxidative Coupling Reactions with N-Phenyltetrahydroisoquinoline JACS article, http://pubs.acs.org/doi...
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Ahamed
Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet–Spengler theme, http://pubs.rsc.org/en...
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Ahamed
Direct oxidative phosphonylation of amines under metal-free conditions, http://www.sciencedirect.com/science...
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Ahamed
Rethinking amide bond synthesis, Vijaya R. Pattabiraman & Jeffrey W. Bode, Nature Review. http://www.nature.com/nature...
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Ahamed
Functionally Diverse Nucleophilic Trapping of Iminium Intermediates Generated Utilizing Visible Light, http://pubs.acs.org/doi...
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All in one! - Ahamed
Matthew Todd
Catalytic Asymmetric Activation of a C sp 3[BOND]H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives - Zhang - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Catalytic Asymmetric Activation of a C sp 3[BOND]H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives - Zhang - 2011 - Angewandte Chemie International Edition - Wiley Online Library
"10.1002/anie.201105123" Combination of Cu and DDQ, but not surprising given Li's example of a similar reaction with alkynes. - Matthew Todd from Bookmarklet
Ahamed
A Structurally Simple Self-Immolative Reagent That Provides Three Distinct, Simultaneous Responses per Detection Event, Scott T. Philips, http://pubs.acs.org/doi...
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Ahamed
Ahamed
Enantioselective Boronate Additions to N-Acyl Quinoliniums Catalyzed by Tartaric Acid, http://pubs.acs.org/doi...
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Old horse doing the trick. - Ahamed
Matthew Todd
An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines - Chemical Communications (RSC Publishing)
"10.1039/C1CC15050B" Really? - Matthew Todd from Bookmarklet
Sometime back, i used V2O5, O2, in toluene to do alcohol oxidation. If i remember correctly R. A. Sheldon used this system in early 80's for various oxidations. The conditions are very old and well known, just two will-work-for-sure substrates. But cant be in Chem Commun. - Ahamed
Ahamed
Homogeneous vs Heterogeneous Polymerization Catalysis Revealed by Single-Particle Fluorescence Microscopy http://pubs.acs.org/doi...
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Ahamed
Visible-light photoredox catalyzed oxidative Strecker reaction, Magnus Rueping http://pubs.rsc.org/en...
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Interesting - Althea it's the nucleophile you're trying to avoid. More evidence of N-Ar need. - Matthew Todd
Ahamed
Total Synthesis of (+)-Yohimbine via an Enantioselective Organocatalytic Pictet–Spengler Reaction http://pubs.acs.org/doi...
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Ahamed
Peter Thiel launches Breakout Labs to fund bold early-stage research http://gigaom.com/2011...
Matthew Todd
Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Brønsted Acid Co-Catalyst - Hashimoto - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Brønsted Acid Co-Catalyst - Hashimoto - 2011 - Angewandte Chemie International Edition - Wiley Online Library
10.1002/anie.201104017 Another rxn on this ring system from Maruoka. Elaborate catalyst system and substrate but which delivers something challenging. One to reference. - Matthew Todd from Bookmarklet
Teasing one. Must have worked hard to optimize this one. - Ahamed
Matthew Todd
Selective Catalytic C–H Alkylation of Alkenes with Alcohols. Science 2011, 333, 1613-1616. - http://www.sciencemag.org/content...
"10.1126/science.1208839" "Preliminary mechanistic studies are inconsistent with Friedel-Crafts–type electrophilic activation of the alcohols, suggesting instead a vinyl C–H activation pathway with opposite electronic polarization. " Soo. Any similarity? - Matthew Todd from Bookmarklet
Ahamed
Copper-Catalyzed Enantioselective Additions to Oxocarbenium Ions: Alkynylation of Isochroman Acetals http://pubs.acs.org/doi...
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Mary P. Watson did a 3 year postdoc with E. N. Jacobsen, so no wonder to see oxocarbenium ion chemistry. - Ahamed
Ahamed
Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride, http://www.sciencedirect.com/science...
Ahamed
A Dual-Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition of O-Acylated Azlactones to Isoquinolines http://pubs.acs.org/doi...
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Our paper cited+again jacobsens chiral thiourea. - Ahamed
Ahamed
Direct Functionalization of (Un)protected Tetrahydroisoquinoline and Isochroman under Iron and Copper Catalysis: Two Metals, Two Mechanisms http://pubs.acs.org/doi...
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Ahamed
A Mild Ligand-Free Iron-Catalyzed Liberation of Alcohols from Allylcarbonates, DOI: 10.1021/ol202270g
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Ahamed
Reporter Protein-Targeted Probes for Magnetic Resonance Imaging http://pubs.acs.org/doi...
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Ahamed
Brønsted acid assisted activation of imide carbonyl group: regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine, http://pubs.rsc.org/en...
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Construction of ISQ ring with different strategy. Possibility of generating chiral center at 1-position using chiral bronsted acid, a well known chemistry developed by Rueping. - Ahamed
Don't see the novelty..? - Matthew Todd
Matthew Todd
Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities - Chemical Reviews (ACS Publications) - http://pubs.acs.org/doi...
10.1021/cr100212h. Big Houk review. Nilupa. - Matthew Todd from Bookmarklet
Ahamed
Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules, http://pubs.rsc.org/en...
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Mingfeng - how often are you checking this feed? - Matthew Todd
Ahamed
Highly Efficient Synthesis of Polysubstituted 1,2-Dihydroquinolines via Tandem Reaction of α-Ketoesters and Arylamines Catalyzed by Indium Triflate, ACS catalysis, http://pubs.acs.org/doi...
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We have made substituted 1,2-dihydroisoquinolines at ease form ISQ. - Ahamed
Ahamed
Unclicking the Click: Mechanically Facilitated 1,3-Dipolar Cycloreversions, DOI: 10.1126/science.1207934
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Dont know how useful this is. Could be useful in targeted drug release, selective in vivo imaging. - Ahamed
Just covered this in group meeting :) - Matthew Todd
Already missing the group meetings. - Ahamed
Matthew Todd
Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate - Chemical Communications (RSC Publishing)
10.1039/c1cc14185f - Matthew Todd from Bookmarklet
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