Trapping of picolyl cations in the reactions of 2- and 4-picoline N-oxide with acetic anhydride - Journal of the American Chemical Society (ACS Publications) - http://pubs.acs.org/doi...
Paper describing the use of anisole to probe the polar (ortho/para) or radical (meta) nature of a bond forming event. Relevant to Soo/Althea
- Matthew Todd
from Bookmarklet
New paper from Zhiping Li - nice iron-catalysed oxidation of CH next to N, here with an interesting cleavage of the N-C bond in the process. Althea, Soo.
- Matthew Todd
from Bookmarklet
One of my MOBT students alerted me to this study that casts doubt on the role of H-bonding in the AT-specificity of netropsin/distamycin binding. It's 25 years old now, but interesting.
- Matthew Todd
If anyone is looking to buy peptide coupling reagents, do check more widely than Sigma Aldrich - e.g. Advanced Chemtech :"RC8110 HATU 100g US$550, RC8116 HCTU 100g US$225, RC8106 HBTU 100g US$90" according to an email they keep sending. Alternatively try Ahamed's super method that obviates the need for them altogether.
Some interesting steps in this Fukuyama synthesis, especially the Friedel-Crafts and the enamide epoxidation (Ahamed). Check out the lactonisation final step. Oxidation of CH next to nitrogen using potassium ferricyanide. That's very nice, and surprisingly selective.
- Matthew Todd
from Bookmarklet
Intresting, i got a similar ring opening (rearrangement) with mCPBA on electron rich PZQ enamide ; proved by X-ray crystal structure. Waiting to get it published.
- Ahamed
:) We can publish it when you finish it...
- Matthew Todd
pHLIP-Mediated Translocation of Membrane-Impermeable Molecules into Cells - http://dx.doi.org/10...
THE CHEMISTRY OF ORGANIC GOLD COMPOUNDS. III. DIRECT INTRODUCTION OF GOLD INTO THE AROMATIC NUCLEUS (PRELIMINARY COMMUNICATION) - Journal of the American Chemical Society (ACS Publications) - http://dx.doi.org/10...
$ for 4-6 month stays in Asia-Pacific for Aus postgrad students - if there's a lab in a participating country you're interested in, this is the way to access some funding.
- Matthew Todd
from Bookmarklet
Changing the local coordination environment in mono- and bi- nuclear lanthanide complexes through “click” chemistry - http://dx.doi.org/10...