Rhodium-Catalyzed Enantioselective Cyclopropanation of Olefins with N-Sulfonyl 1,2,3-Triazoles - Journal of the American Chemical Society (ACS Publications) - http://pubs.acs.org/doi...
The foldit game I was talking about over lunch - very good example of use of computer games in science. Exploits some natural human strengths.
- Matthew Todd
from Bookmarklet
Its is a unique way of doing science, The guy who does this is Dr. Zoran Popović (http://www.cs.washington.edu/homes...). An intresting web site he has. I heared one of his PhD student's project is based entirely on the results he get through the site. As far as i know they havent published anything based on the results from fold-it. Intresting to see how they will manage to publish stuff out of it.
- Ahamed
Rzepa applies the anthropic principle to amide bond rotation. [Note to self - how do dipoles help explain the Me inequivalence of dimethylformamide?]
- Matthew Todd
from Bookmarklet
Couldn't you change the parameters in the model he mentions to see what chemistry would be like in a 'different' universe? I think that would be very interesting.
- Andrew Lang
Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C-H Olefination -- Wang et al., 10.1126/science.1182512 -- Science - http://www.sciencemag.org/cgi...
Couldn't we use something like this for inputting 3-D molecular models?
- Matthew Todd
from Bookmarklet
I'd like to use this to generate models of my experimental setups. Would make it so much easier to generate figures from for M&M sections. Open source software? Couldn't find a download link...
- Björn Brembs
looks really cool, fast input of hand made molecular models seems like a good possibility, couldn't find any software either though
- Mike Chelen
Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines - Journal of the American Chemical Society (ACS Publications) - http://pubs.acs.org/doi...
Nice example of benzylic C-N functionalisation to effect an intramolecular cyclisation. Not a net oxidation - apparent hydride transfer. Althea. "10.1021/ja905213f"
- Matthew Todd
from Bookmarklet
Nice Bachrach post discussing Jacobsen's recent Strecker mechanism. A beautiful level of detail here of the sequence of events in a thiourea-catalysed reaction. Nilupa.
- Matthew Todd
from Bookmarklet
Bachrach post on importance of dynamics in transition states - i.e. that reaction outcomes from possible transition states are time-dependent (atoms are moving in a certain direction, giving rise to certain products).
- Matthew Todd
from Bookmarklet
Direct transformation of methyl arenes to nitriles using a simple and mild oxidation of the tolyl position and azide reagent. Victor. 10.1002/anie.200903838
- Matthew Todd
from Bookmarklet
Mechanistic study of cinchona catalysis, confirming cooperative catalysis involving H-bonding activation and quinuclidine-centered general base catalysis.
- Matthew Todd
from Bookmarklet
Analysis of Soai reaction proposing barrel-like tetrameric intermediates. A combination of Kagan ML2 and Noyori reservoir effects in one system.
- Matthew Todd
from Bookmarklet
ScienceDirect - Journal of Molecular Catalysis A: Chemical :
Iridium-catalyzed benzylic C–H activation and functionalization of alkyl arenes - http://www.sciencedirect.com/science...
Efficient N-Demethylation of Opiate Alkaloids Using a Modified Nonclassical Polonovski Reaction - The Journal of Organic Chemistry (ACS Publications) - http://pubs.acs.org/doi...
Trapping of picolyl cations in the reactions of 2- and 4-picoline N-oxide with acetic anhydride - Journal of the American Chemical Society (ACS Publications) - http://pubs.acs.org/doi...
Paper describing the use of anisole to probe the polar (ortho/para) or radical (meta) nature of a bond forming event. Relevant to Soo/Althea
- Matthew Todd
from Bookmarklet