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Organocatalytic Asymmetric 1,4-Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether
http://pubs.acs.org/doi...
A Comparative Mechanistic Study of Cu-Catalyzed Oxidative Coupling Reactions with N-Phenyltetrahydroisoquinoline
JACS article, http://pubs.acs.org/doi...
Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet–Spengler theme, http://pubs.rsc.org/en...
Direct oxidative phosphonylation of amines under metal-free conditions, http://www.sciencedirect.com/science...
Althea Tsang liked this
Rethinking amide bond synthesis, Vijaya R. Pattabiraman
& Jeffrey W. Bode, Nature Review.
http://www.nature.com/nature...
Functionally Diverse Nucleophilic Trapping of Iminium Intermediates Generated Utilizing Visible Light, http://pubs.acs.org/doi...
All in one!
- Ahamed
Catalytic Asymmetric Activation of a C sp 3[BOND]H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives - Zhang - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Ahamed liked this
"10.1002/anie.201105123" Combination of Cu and DDQ, but not surprising given Li's example of a similar reaction with alkynes.
- Matthew Todd
from Bookmarklet
A Structurally Simple Self-Immolative Reagent That Provides Three Distinct, Simultaneous Responses per Detection Event, Scott T. Philips, http://pubs.acs.org/doi...
Enantioselective Boronate Additions to N-Acyl Quinoliniums Catalyzed by Tartaric Acid, http://pubs.acs.org/doi...
Old horse doing the trick.
- Ahamed
An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
"10.1039/C1CC15050B" Really?
- Matthew Todd
from Bookmarklet
Sometime back, i used V2O5, O2, in toluene to do alcohol oxidation. If i remember correctly R. A. Sheldon used this system in early 80's for various oxidations. The conditions are very old and well known, just two will-work-for-sure substrates. But cant be in Chem Commun.
- Ahamed
Homogeneous vs Heterogeneous Polymerization Catalysis Revealed by Single-Particle Fluorescence Microscopy
http://pubs.acs.org/doi...
Visible-light photoredox catalyzed oxidative Strecker reaction, Magnus Rueping http://pubs.rsc.org/en...
Matthew Todd liked this
Interesting - Althea it's the nucleophile you're trying to avoid. More evidence of N-Ar need.
- Matthew Todd
Total Synthesis of (+)-Yohimbine via an Enantioselective Organocatalytic Pictet–Spengler Reaction
http://pubs.acs.org/doi...
Michael Wolfle liked this
Peter Thiel launches Breakout Labs to fund bold early-stage research
http://gigaom.com/2011...
Matthew Todd liked this
Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Brønsted Acid Co-Catalyst - Hashimoto - 2011 - Angewandte Chemie International Edition - Wiley Online Library - http://onlinelibrary.wiley.com/doi...
Michael Wolfle liked this
10.1002/anie.201104017 Another rxn on this ring system from Maruoka. Elaborate catalyst system and substrate but which delivers something challenging. One to reference.
- Matthew Todd
from Bookmarklet
Teasing one. Must have worked hard to optimize this one.
- Ahamed
Selective Catalytic C–H Alkylation of Alkenes with Alcohols. Science 2011, 333, 1613-1616. - http://www.sciencemag.org/content...
"10.1126/science.1208839" "Preliminary mechanistic studies are inconsistent with Friedel-Crafts–type electrophilic activation of the alcohols, suggesting instead a vinyl C–H activation pathway with opposite electronic polarization. " Soo. Any similarity?
- Matthew Todd
from Bookmarklet
Copper-Catalyzed Enantioselective Additions to Oxocarbenium Ions: Alkynylation of Isochroman Acetals
http://pubs.acs.org/doi...
Mary P. Watson did a 3 year postdoc with E. N. Jacobsen, so no wonder to see oxocarbenium ion chemistry.
- Ahamed
Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride, http://www.sciencedirect.com/science...
A Dual-Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition of O-Acylated Azlactones to Isoquinolines
http://pubs.acs.org/doi...
Our paper cited+again jacobsens chiral thiourea.
- Ahamed
Direct Functionalization of (Un)protected Tetrahydroisoquinoline and Isochroman under Iron and Copper Catalysis: Two Metals, Two Mechanisms
http://pubs.acs.org/doi...
A Mild Ligand-Free Iron-Catalyzed Liberation of Alcohols from Allylcarbonates, DOI: 10.1021/ol202270g
Reporter Protein-Targeted Probes for Magnetic Resonance Imaging
http://pubs.acs.org/doi...
Brønsted acid assisted activation of imide carbonyl group: regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine, http://pubs.rsc.org/en...
Construction of ISQ ring with different strategy. Possibility of generating chiral center at 1-position using chiral bronsted acid, a well known chemistry developed by Rueping.
- Ahamed
Don't see the novelty..?
- Matthew Todd
Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities - Chemical Reviews (ACS Publications) - http://pubs.acs.org/doi...
10.1021/cr100212h. Big Houk review. Nilupa.
- Matthew Todd
from Bookmarklet
Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules, http://pubs.rsc.org/en...
Mingfeng - how often are you checking this feed?
- Matthew Todd
Highly Efficient Synthesis of Polysubstituted 1,2-Dihydroquinolines via Tandem Reaction of α-Ketoesters and Arylamines Catalyzed by Indium Triflate,
ACS catalysis, http://pubs.acs.org/doi...
We have made substituted 1,2-dihydroisoquinolines at ease form ISQ.
- Ahamed
Unclicking the Click: Mechanically Facilitated 1,3-Dipolar Cycloreversions, DOI: 10.1126/science.1207934
Dont know how useful this is. Could be useful in targeted drug release, selective in vivo imaging.
- Ahamed
Just covered this in group meeting :)
- Matthew Todd
Already missing the group meetings.
- Ahamed
Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid–cyclen conjugate - Chemical Communications (RSC Publishing) - http://pubs.rsc.org/en...
10.1039/c1cc14185f
- Matthew Todd
from Bookmarklet
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