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Jonathan Eisen › Comments

Jonathan Eisen
My new Nature paper: A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea (w/ CC license - yay) - http://www.nature.com/nature...
Kudos for getting the CC license! - Bill Hooker
Absolutely =) - Graham Steel
I note that the data for the project, in addition to being in Genbank and at the JGI IMG sites, is now available in Biotorrents at http://www.biotorrents.net/details... - Jonathan Eisen
Jonathan - How did you get the CC license? - Michael Nielsen
I wrote briefly about the CC license thing on my blog a while ago here: http://phylogenomics.blogspot.com/2008... ... I think it is only done for papers reporting new genome sequence data. - Jonathan Eisen
Ah, very nice. It's useful to know about that policy from Nature. When I publish material related to open science I usually have a chat with my editor about licensing - this is the kind of thing that will be useful to bring up in future discussions. - Michael Nielsen
Nature announced a Creative Commons license for all genome papers in December 2007: http://dx.doi.org/10... - Martin Fenner
Worth noting that this was in response to strong community demands coming out of the controversy over the public and private genome projects as I understand it. Other communities take note (looking at you structural biology...) - Cameron Neylon
Two cancer genomes published in Nature last week also have Creative Commons license: http://dx.doi.org/10... and http://dx.doi.org/10... - Martin Fenner
Well, for many years (dating way back ...) Nature made genome papers available for free - and amazingly to me they have stuck to this. I do not think this was due to the public vs. private debates per se but I guess we could ask some of the old timers. Chris Gunter, who was an Nature back then and handled many of the genome papers, was involved in some way with this "openness" policy. The move to CC licenses in 2007 was a pleasant surprise too ... - Jonathan Eisen
Kudos also for getting the Nature paper. Merry Christmas. - Matthew Todd
I wrote a bit more about the paper and the story behind the story here: http://phylogenomics.blogspot.com/2009... - Jonathan Eisen
Thanks for the fascinating blog post. As one commenter said, longer than the Nature paper itself. I wish we had more blog posts like this where authors write about their just published papers. - Martin Fenner from iPhone
+1 Martin! Even better if authors were allowed to write to write their papers the way they want and wouldn't have to write blog posts - hint: paper: four pages, supplement: 10 pages. Supplements must be among the most absurd outgrowths of our decrepit publishing system... - Björn Brembs
Well, Bjorn and Martin, I agree and disagree. Certainly, forcing papers to be a certain length, to me, is silly, and is Yet Another Reason I like PLoS, since they have no specific restrictions on page lengths in most cases. And I completely agree that supplemental material is mostly inane. In fact, in my PLoS One, PLoS Bio and other PLoS papers I have tried to put as little as possible... more... - Jonathan Eisen
@Jonathan: I wrote the comment before I read the largely biographical blog post :-) Either way, being forced to be concise is indeed (often? sometimes?) a good thing, but can be done without the insane page limits of some journals. On the other hand, who but the author would have the right to force brevity? Put another way, shouldn't an author be allowed to completely spoil their work... more... - Björn Brembs
Unfortunately there is still a lot of work to be done before we can easily find all blog posts talking about a particular paper. Nature and other journals should follow the lead of PLoS with linking to blog posts directly from the paper webpage. And tools such as Researchblogging.org, Nature.com Blogs or Streamosphere should do a better job of aggregating all blog posts about a particular paper together. - Martin Fenner
Bjorn: 1) Author should indeed be in charge of length in my opinion as well as form in many other ways 2) Does not hurt to have editors who suggest things that might make a paper better. 3) As for understandability, I think part of the review of a paper, including in journals like PLoS One, should be whether or not what is written correctly explains what was done and correctly explains... more... - Jonathan Eisen
Jonathan Eisen
BBC Mundo - Ciencia y Tecnología - ¿Cuántos microbios viven en la Tierra? - http://www.bbc.co.uk/mundo...
Cool - my GEBA project made it into BBC World, Spanish version - Jonathan Eisen from Bookmarklet
Jonathan Eisen
Supplement For Dogs uses "shark cartilage" http://bit.ly/73RxZ but says "no sharks harmed" huh? - http://www.doggonepain.com/
The last entry says: Shark cartilage is the skeletal material of shark and has been consumed as a health food in traditional Chinese medicine for its broad anti-aging benefits. Recent scientific studies have confirmed its benefits for the treatment and prevention of degenerative joint disease. It is an excellent dietary source of chondroitin sulfate and other glycoaminoglycans that rebuild cartilage, and calcium, magnesium, phosphorus, zinc and other bone building minerals. No sharks are caught in the manufacture of this product, the sharks used are harvested for sale as seafood, the cartilage is a by-product. Toxicity studies have shown it to be safe and non-toxic at all but extremely high doses. - Jonathan Eisen
Jonathan Eisen
All Slim Fast canned drinks recalled due to possible Bacillus cereus contamination - http://www.msnbc.msn.com/id...
Note - an interesting exercise in bacterial systematics here. B. cereus could in some people's minds be called a different strain of Bacillus anthracis. Imagine however, the effect that a news story saying "anthrax in Slim Fast drinks" would have. - Jonathan Eisen from Bookmarklet
Jonathan Eisen
Systems Biology of Microorganisms March 22-24 2010 Institut Pasteur Paris - http://www.systemsmicrobiology.org/
Not sure if this will be good but seems like it has potential - Jonathan Eisen from Bookmarklet
Jonathan Eisen
Short Stack - Probing Genesis for scientific truth from Andrew Parker, NHM - http://voices.washingtonpost.com/shortst...
The best line is re: "let there be light " where he implies that the first bio use of light was vision not photosynthesis - Jonathan Eisen from iPhone
Jonathan Eisen
Minigiving.Org: 'Save the world while shopping' - % to International Rescue Committee - http://minigiving.org/
set up by Gerard Manning from Salk who writes "Two years ago, I asked you all with a very small favor, to use a website I created - http://minigiving.org - when shopping online. The site has links to a bunch of major online retailers. Simply by clicking from there to a retailers site, anything you buy in that session pays a commission (usually 5-8%) to minigiving, which then goes 100% to the International Rescue Committee (IRC), one of the most respected and efficient of international charities. It seemed like a slightly crazy idea at the time (at least to me), but just by emailing you and some of my work colleagues, we raised over a thousand dollars for refugees that shopping season. This time around, the site is stable, I've worked out the ways to handle the finances (I may the minor costs to run the site, so all commissions still go 100% to the IRC) and so I'd like you consider using the site again and - this is the bigger request - please pass on the word about minigiving to as... more... - Jonathan Eisen from Bookmarklet
Karen James
Good pancakes: 1c milk, 1c yogurt, 1 egg, 1/2t salt, 1/2t baking soda, 1/4c melted butter, 1c whole uncooked oats, 1c whole wheat flour.
May try - Sunday is pancake day Here and I always try to experiment - Jonathan Eisen from iPhone
Jonathan Eisen
Hacked E-Mail Data Prompts Calls for Changes in Climate Research - NYTimes.com - push for more openness - http://www.nytimes.com/2009...
"She and other scientists are seeking more transparency in the way climate data is handled and in the methods used to analyze it." - Jonathan Eisen from Bookmarklet
Jonathan Eisen
Paris Evolution Sale: From Dinosaurs to Space Diapers - ABC News - http://abcnews.go.com/Enterta...
How about we sell some issues of PLoS One too? - Jonathan Eisen from Bookmarklet
Jonathan Eisen
European Studies Find Unexpected Complexity in Compact Bacterial Genome - http://www.genomeweb.com/...
"The extraordinary information now available for M. pneumoniae sets a new standard for understanding systems-level questions about bacterial physiology and evolution." say Howard Ochman and Rahul Raghavan in a commentary - Jonathan Eisen from Bookmarklet
I personally am not surprised -- in the last 10 years we keep uncovering more and more complexity in bacteria, even ones with small genomes. - Jonathan Eisen
Jonathan Eisen
Building an Openscience Twitter list and added to Listorious http://listorious.com/phyloge... #openaccess #openscience - please suggest others
Jonathan Eisen
Verena von Pfetten: UCLA Student Schools Kirk Cameron On Evolution (VIDEO) - http://airamerica.com/enterta...
Sort of entertaining - Jonathan Eisen from Bookmarklet
Jonathan Eisen
Worst new omics word award: Negatome - http://phylogenomics.blogspot.com/2009...
Is there no end to the horror of the buzzword-ome? - Bill Hooker
So, should we come up with a new buzzfix then? So far, we had 'science', 'omics', ... who knows what next... I'm betting on complexity... so, proteoplex, bioplex, chemplex, metaboplex, ... not merely the individuals, but also the complexity between them. - Egon Willighagen
I like the complexity angle - we should register all those domain names - Jonathan Eisen
Jonathan Eisen
Overselling genomics headline of day: Decoded Corn Genome Promises Higher Yields, Better Biofuels, New Plastics - http://www.popsci.com/node...
Let's not forget cure cancer, cut through metal, and pick up any stain. It's all there, in the Science paper. - Shiran Pasternak
Thank goodness. Been very worried about how to cut through metal these days - Jonathan Eisen
Jonathan Eisen
PLoS Genetics: 2009 Maize Genome Collection - http://collections.plos.org/plosgen...
Good to have this collection. Bizarre that they do not list all authors on the collection page and instead to "et al ..." for most of the papers. - Jonathan Eisen from Bookmarklet
Jonathan Eisen
phyloseminar.org -great idea -see Ward Wheeler 12/7 on "Dynamic homology & phylogenetic systematics" - http://phyloseminar.org/
thanks to Erik Matsen for putting this together - Jonathan Eisen from Bookmarklet
Kaitlin Thaney
acquiring 4.4 lbs of pork belly from the butcher and then almost hugging him with excitement is my idea of a perfect saturday morning.
OK - I am sure you have your reasons. But yuck. - Jonathan Eisen
are you a vegetarian? b/c that's the only reason i can think of where a reaction would be "yuck" ;) - Kaitlin Thaney
mmmm...pork belly.... - Mr. Gunn
I'll see your four pounds and raise you 2kg and eight scallops... :-) - Cameron Neylon
not strictly a vegetarian, though I do not eat mammals - but it was the volume that was getting me not the item - Jonathan Eisen
In my case it was the smallest I could get - will be cutting up and freezing most of it. I think Kaitlin is making a large quantity of Rillettes for Thanksgiving(?) - Cameron Neylon
4 lbs of it :) not just for thanksgiving consuption, of course. - Kaitlin Thaney
Someone had to do it.... "I went into a butcher and said I bet you can reach those pieces of meat up there. The butcher said he couldn't take that bet. I asked him why not. He replied because the steaks are too high." - Graham Steel
// taps microphone. "is this thing on?" :) ba-dum-bump-tchhhhhhhh. - Kaitlin Thaney
LOL - This url comes in handy from time to time http://www.instantrimshot.com/ - Graham Steel
for a second i thought you were sending something NSFW. that's awesome. - Kaitlin Thaney
oh, i just looked up a recipe - that sounds really good! I just got like 8lbs of pork butt for $0.85/lb (cheap for any type of meat) so it's a vindaloo for din-din and the other half in the freezer. - Christina Pikas
Is this a 'what to do with pork channel' or what. Am about to de-skin "10 premium chipolatas made with british pork blended with parsley and nutmeg" to add into my new chilli con carne recipe. Stealing some tips from here http://www.bbcgoodfood.com/recipes... and here http://en.wikipedia.org/wiki... - Graham Steel
Maybe I should liveblog this afternoon's cooking :-) - Cameron Neylon
Stranger things have happened ;-) http://mcblawg.blogspot.com/2009... - Graham Steel
Alrighty then.... - Cameron Neylon
Jonathan Eisen
@cupton1 Re: Bioinformatics of microbial genomic survey - we are doing some - always want help - data is all being released too
Well, like of course --- - Jonathan Eisen
Ok, will look forward to hearing from you or Morgan! - Ruchira S. Datta
I was under the impression via JGI people that you folks already were looking at GEBA data (GEBA = Genomic Encyclopedia of Bacteria and Archaea) --- is that not true? - Jonathan Eisen
No, I haven't heard anything from them. - Ruchira S. Datta
Jonathan Eisen
UBC scientist purifying mine waste with bacteria #metagenomics #bioremediation - some good quotes in here - http://www.cbc.ca/canada...
Quote 1 "But the tiny life forms are not completely reliable." - Jonathan Eisen
"Isolating each microbe, and sequencing its genome … would take forever," said Baldwin. "We try to capture the 'metagenome' of the whole community." - Jonathan Eisen
Jonathan Eisen
1 thing I love about teaching introbio at #UCDavis-topics inspire my kids-here's Analias take on box jellies http://twitpic.com/ptkri
1 thing I love about teaching introbio at #UCDavis-topics inspire my kids-here's Analias take on box jellies http://twitpic.com/ptkri
UCDavis courses are teh roxxors!! Invertebrate Zoology with Grosberg and Systematics with Art Shapiro FTW - Kevin Z
I want to take Gorsbergs and Shapiros classes - maybe they will let me audit - Jonathan Eisen
I love how art teaches systematics. Each student got a bucket of hardware and we classified it according to various methods, i.e. phenetics, cladistics, evolutionary phylogenetics. It was interesting how things changed depending on how you applied the rules. Of course any of Grosberg's classes are worth sitting in, he is so dedicated. I forced myself to work in his lab, left him with no... more... - Kevin Z from twhirl
Neil Saunders
BioTorrents allows scientists to rapidly share their results, datasets, and software using the popular BitTorrent file sharing technology. - Neil Saunders
ok, that's fine, but are there any research organizations that still allow p2p over their networks? - Christina Pikas
still allowed at UC Davis where Morgan L. (who is in my lab) set up Biotorrents - Jonathan Eisen
Not sure if my workplace has a policy, but it's not blocked - I've used it for Ubuntu ISOs. Might be a different story if I were downloading TV shows. - Neil Saunders
Is there advantage / complement over institutional repository? Embarrassed to say I've never used bit torrent. - Steve Koch
@Christina - I'm pretty sure my institution blocks (or forbids) BitTorrent, although I think they may allow certain IP addresses to be 'whitelisted'. AFAIK this method of distribution was considered for large diffraction datasets in the TARDIS project, but for the reasons above, it was not implemented. Also, BitTorrent works best when there are lots of seeders - for some datasets the... more... - Andrew Perry
sorry - my comment reads now as really bitchy. beyond the various copyright issues, some denial of service attacks are done by zombie networks controlled through p2p and hackers can exfiltrate information via p2p so I would suspect more institutions will block p2p in the future. maybe with whitelists or only during working hours or something would work. - Christina Pikas
@Steve bit torrent is often much faster than an institutional repository. Download the client and then grab the latest Ubuntu ISO. You will be surprised. - Doug Hershberger from iPhone
Jonathan Eisen
Some good papers in Nature Methods special (free) issue on Next Gen Seq. Analysis - http://www.nature.com/nmeth...
Particularly liked this one by Ewan Birney and Paul Flicek http://www.nature.com/nmeth... - Jonathan Eisen
Jonathan Eisen
Larry Forney from U. Idaho at #NASMH is talking about the vaginal microbiome
Common wisdom - Lactobacilli indicative of good health - Jonathan Eisen
Also common wisdom - growth of non indiginous organisms suppressed by Lactobacillus - Jonathan Eisen
Vagina microbiome changes over time in part w/ changes in estrogen levels - Jonathan Eisen
What he is studying - variation within and between women - Jonathan Eisen
Example - 410 asymtomatic healthy women - four ethnic groups - self collected swabs - measured pH, history, and then did pyrosequencing of 16s - Jonathan Eisen
Multiple kinds of core microbiomes among these women - Jonathan Eisen
Dominated by lactic acid bacteria - Jonathan Eisen
Suggests that there is strong host selection for which organisms are present - but not clear what the basis for this statement is - Jonathan Eisen
Consistent w/ Walker's Driver Passenger Model (ecological model)_ which is smilar to keystone species model 0 and that here the keystone species are lactic acid bacteria - Jonathan Eisen
Vaginal pH and microbial state varies by ethnic group - - Jonathan Eisen
ok, i read that as "microphone"... nevermind. - Christina Pikas
Jonathan Eisen
Gregor Reid, U. Western Ontario, is waiting for his slides to come up after a PC crash and cracking some brilliant jokes at #NASMH
'We started this work and nobody was willing to fund it so we paid it ourselves and there will be no acknowledgements at the end' - Jonathan Eisen
Estimate of over 1 billion urogenital infections per yer - Jonathan Eisen
He is continuing to crack jokes now that slides are working - definitely worth inviting him to your meetings if you need a comedian - Jonathan Eisen
Anyway - focus on his talk on vagina microbiome - Jonathan Eisen
Sequenced Lactobaillus iners genome - pretty small - Jonathan Eisen
I can see why no one was willing to fund it. Isn't it the NIH Man Microbiome Project? - Ruchira S. Datta
NIH Microbiome project funding a lot of vagina studies ... - Jonathan Eisen
but he is not in US - Jonathan Eisen
Looking at pobiotic lactobacilli for vaginal health - Jonathan Eisen
Well, the NIH does fund projects outside the US too, no? - Ruchira S. Datta
But, yeah, it makes sense to prioritize the ones within the US, I guess. - Ruchira S. Datta
Jonathan Eisen
Dennis Kasper from Harvard / Brigham is now up at #NASMH on "Bacterial cell surface glycans as therapeutic agents"
See a new paper on PLOS Pathogens by him here http://www.ncbi.nlm.nih.gov/pubmed... - Jonathan Eisen
Focusing his talk on one molecule in Bacteroides fragilis - Jonathan Eisen
Hey - and look at this paper on which he and I are coauthros - http://www.pnas.org/content... - forgot about this - Jonathan Eisen
Says when the genome was analyzed there were some surprises - - Jonathan Eisen
Polysac from this organism called PSA - is unusual in having a NH3 group at one side - - Jonathan Eisen
Jonathan Eisen
Now speaking at #NASMH - Gunnar Hanson on mucus regulation of host microbial interactions
Bacteria in the gut hang out in the mucus outer layer and are not in direct contact with intestinal cells - Jonathan Eisen
Five mucin genes in human genomes - one of them is not used apparantly - Jonathan Eisen
Refers to really strange 'phylogenetic tree' of mucins - see http://www.pnas.org/content... - Jonathan Eisen
What do bacteria do in mucus outer layer? One thing is that they degrade the oligosaccharized on the mucus and eat them. - Jonathan Eisen
Inner mucus layer is the protection for intestinal cells - Jonathan Eisen
Outer layer is the home for commensals - Jonathan Eisen
Jonathan Eisen
Getting ready for David Mills from #UCDavis to talk at #NASMH about "the human milk glycobiome & infant microbiota"
Here is his home page http://mills.ucdavis.edu/ - Jonathan Eisen
David notes that in the goody bag that they gave speakers they put a bottle of Mondavi wine - which is good given that David is in the Mondavi Institute - Jonathan Eisen
Says that there is a big project at UCDavis to characterize every component of human milk - Jonathan Eisen
What is in human milk: lactose, fat, protein, oligosaccharides. The first three are consumed by the infant. But oligosaccharides are not. - Jonathan Eisen
Human milk oligosaccharides come in > 200 different forms - Jonathan Eisen
Maybe oligos are "prebiotics" - Jonathan Eisen
Studying baby poop "If you were born in the last year in Davis we probably have your poop" - Jonathan Eisen
Human milk oligosaccharides abreviated as HMOs - should have come up with something different - Jonathan Eisen
"Obtained a lot of human milk (which is not so easy)" - Jonathan Eisen
Comparing the growth of different Bifidobacteria species on HMOs - Jonathan Eisen
Which oligosaccharides are being consumed by these? Needed a glycochemist - Jonathan Eisen
"I am not a chemist, but I did stay at a Marriott last night" - Jonathan Eisen
Refers to Dave Sela's (http://mills.ucdavis.edu/das...) work and paper on genome sequencing of some of these genomes http://www.pnas.org/content... - Jonathan Eisen
Bifidobacterium longum infantis were the best at using HMOs - Jonathan Eisen
Enteroendocrine cells seem to respond sepcifically to byproducts of B. infantis - Jonathan Eisen
Just showed a picture w/ Bifidobacterium looking happy with smiles and big eyes ... - Jonathan Eisen
Suggests tripartite evolutionary relationship - milk, infant, microbes - Jonathan Eisen
Jonathan Eisen
Ruth Ley at #NASMH talking about development of infant gut microbiota
As with MANY others at this meeting - using 454 sequencing of rRNA to study microbial communities - Jonathan Eisen
Doing a case study of colonization of human infant - refs Palmer et al PLoS Bio paper as seminal http://www.plosbiology.org/article... - Jonathan Eisen
Ley says one key question was why there were large variations w/in individuals over time in Palmer et al. PLoS Bio study - Jonathan Eisen
As with David Relman, Ley refs. Jared Diamond on community co-occurrence - Jonathan Eisen
Jonathan Eisen
Karen Guillemin from U. Orgeon http://www.molbio.uoregon.edu/facres... is now talking at #NASMH re: germ free zebrafish studies
Why zebrafish? can make germ free, gut/immune similar to mammals, good genetics - Jonathan Eisen
Microbiota in zebrafish play a role in gut development - Jonathan Eisen
Had lunch w/ her today - exceptionally impressed - doing cool host-microbe interaction work - Jonathan Eisen
Zebrafish alkaline phosphatase involved in detoxifying LPS from intestinal microbiota - Jonathan Eisen
Now talking about collaborating with the other J. Eisen (zebrafish guru Judith at U. Orgeon) - Jonathan Eisen
Another key technique: can transplant microbiota between animals - Jonathan Eisen
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