Tobias - FriendFeed

Literaturverwaltung mit Endnote, Mendeley und Co. - http://www.scienceblogs.de/weiterg...

January 30 from WeiterGen - Comment - Like - Share

Frosch vs. Smartphone - http://www.scienceblogs.de/weiterg...

December 27 from WeiterGen - Comment - Like - Share

Angst vor dem Grippevirus aus dem Labor? Veröffentlichung der Daten ja oder nein? http://t.co/am5oPzzx #blogpost

December 22 from Twitter - Comment - Like - Share

Veröffentlichungsverbot - Angst vor der Grippe aus dem Labor - http://www.scienceblogs.de/weiterg...

December 21 from WeiterGen - Comment - Like - Share

Viel hilft viel - Deutsche Wissenschaft im internationalen Vergleich - http://www.scienceblogs.de/weiterg...

November 23 from WeiterGen - Comment - Like - Share

Die internationale Finanzkrise als Chance für den Wissenschaftsstandort Deutschland - http://www.scienceblogs.de/weiterg...

October 15 from WeiterGen - Comment - Like - Share

Forscher in Deutschland publizieren überdurchschnittlich gut - bis auf die Sozialwissenschaftler - http://www.scienceblogs.de/weiterg...

October 5 from WeiterGen - Comment - Like - Share

Auch bei mir im Blog finden wir keine Lösung für den Nahostkonflikt. http://www.scienceblogs.de/weiterg...

September 29 from Twitter - Comment - Like - Share

Abbas und Netanyahu vor der UN-Generalversammlung - http://www.scienceblogs.de/weiterg...

September 24 from WeiterGen - Comment - Like - Share

Proteopedia - 3D Strukturbiologie für alle - http://www.scienceblogs.de/weiterg...

September 22 from WeiterGen - Comment - Like - Share

Thats it, now lunch break with a chance to ask questions to all speakers. Entschuldigung fürs Timeline-spammen #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Next step. 20000- 30000 whole genomes of cancer patients. Lots to expect, fine grained image on cancer causes and progression. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

This is cool stuff. By looking at genome rearrangements one can derive a phylogenetic tree of metastasis. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Metastasis have gone through single cell bottleneck, therefore "heredity" from primary tumor easily traceable #EMBOmtg

September 11 from Twitter - Comment - Like - Share

How and where do cancers metastasize? Sequence the mestastases, check for rearangements, see how similar they are to primary tumor #EMBOmtg

September 11 from Twitter - Comment - Like - Share

What the underlying mechanisms for these specific profiles are is unknown. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

What type of mutations occur? Typical signature profiles for different cancer patients. (i,e. C to T in some, C to A in others) #EMBOmtg

September 11 from Twitter - Comment - Like - Share

How many overall mutations occur in cancer patients. High variability. From only a few to up to over 7000 (seven hundred!!) #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Bottom line: High genetic variability among different breast cancer types. different number and different types of mutations. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

About half of all cases only need 1 or two driver mutations. those are enrichted in point mut. CNV in cancers with more mutations #EMBOmtg

September 11 from Twitter - Comment - Like - Share

How many different mutations are necessary to cause cancer? Tranditional view: 5-7 Stratton shows higher variability. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

So which genes are actually mutatet in these 69 breast cancers? At least 34 different genes, p53 most common. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

What type of mutations are most common in cancer genes? By far truncations. Missense occurs only in functionally important loci. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Sequencing of 69 different breast cancers, see which mutations and what type of mutations occur, identify new cancer genes. #EMBOmtg

September 11 from Twitter - Comment - Like - Share

The landscape of cancer driver mutations. Mutations in which genes lead to the transformation of normal cells to cancer cells? #EMBOmtg

September 11 from Twitter - Comment - Like - Share

At least 416 genes are known to be causually implicated in human cancer (one of them being p53, for example) most are dominant #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Mike Stratton is the head of the Sanger Center, for those of you who do not know him.

September 11 from Twitter - Comment - Like - Share

I'll switch to English for the next tweets on Mike Strattons Talk. They are streamer on the #EMBOmtg website http://t.co/6gvnchg

September 11 from Twitter - Comment - Like - Share

Mike Stratton jetzt über Krebszellgenome. Was unterscheidet Krebszellen von normalen Zellen? Was sind die "Driver Mutations" #EMBOmtg

September 11 from Twitter - Comment - Like - Share

Beim #embomtg in Wien. Eben Chaperone und Prione von Susan Lindquist, Jetzt Session über Genomevolution u.a. mit Michael Stratton

September 11 from Twitter - Comment - Like - Share