Yaroslav Nikolaev

A rather more compelling reason to be interested in Open systems than competitive advantage for individual scientists... - Bill Hooker

would be interesting to run a simulation of an extensive (i.e. bigger than flat & round worms) multicellular system bearing neurocrine, but lacking circulatory-endocrine communication...do you have any experts in mind? ;-) - Yaroslav Nikolaev

Unfortunately, no -- but if there are any to be found, I suspect they are on FF. :-) - Bill Hooker

In this essay we attempt to reconsider the concept of the “Leucine Zipper” (LZ) protein oligomerization motif. Reasoning on the wealth of existing data, we suggest that despite of the structural similarity with highly stable extended “Coiled Coil” motifs, on the functional level short and moderately stable “Leucine Zippers” might stand out as a distinct group. Namely, this family of oligomerization motifs facilitates combinatorial protein-protein recognition in the course of signal transduction events, thus going beyond the structural role of the extended “Coiled Coils”. Summarizing the existing knowledge on stability, specificity and folding of Leucine Zippers we demonstrate how a simple set of rules, applied in the context of the universal coiled coil scaffold, creates a robust LZ interaction vocabulary. Owing to the high abundance of Leucine Zippers, this motif might account for coupling of distinct protein signalling pathways into a unified intracellular signalling network. In the... more... - Yaroslav Nikolaev

Uh ty, Nature Precedings! Ne znal o takom. Chem -to napominaet PLOS. - Andrei

Recommended? - Andrei

What do you think? - Andrei

The book is good, but I like his article "Coase's Penguin" even more in many ways (just Google it). - Michael Nielsen

it's a pretty dense read - Richard Akerman