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Pierre Lindenbaum › Likes

Paulo Nuin
You drive a big heavy fire truck. Grandma is approaching from the left, on her bike. Do you C) go forward? - http://www.reddit.com/r...
For the lazy people, just go directly to the action: http://bit.ly/4DXwZv - Lars Juhl Jensen
Wow, it seems that Google has decided to censor out the interesting image - Lars Juhl Jensen
When turning 180° later http://tinyurl.com/yh65ojc you can see that grandma was safe, and the truck has gone. So I guess, Google's staff stopped to help her - Pierre Lindenbaum
mirror of the image Google removed: http://i.imgur.com/deTJ8.jpg - Michael Kuhn
Maybe the fire truck had nothing to with the accident. Maybe grandma saw the Google Street View car and go so excited that she fell on her bicycle ;-) - Lars Juhl Jensen
Michael Barton
Visa, viva, vici! I've got my visa and just passed my viva.
congratulations! - Simon Cockell
Thanks everyone. I'm in the pub making the moat of it. Being mocked for going online too. - Michael Barton from iPod
Drinks all around ;) - Pedro Beltrao
@Michael Congratulations! - Duncan Hull
Congratulations^2! - Bill Hooker
Congratulations - Frank from iPhone
Congratulations Michael ! - Pierre Lindenbaum
What they all said. So where are you off to and to do what? - Neil Saunders
Congratulations! All the best! - Ricardo Vidal
Thank you everyone, was nice to read this morning. - Michael Barton
Danny Ayers
♺ @gridinoc: Brilliant: “Pidgeon: impossible” http://www.youtube.com/watch... (via @codepo8) [for @common_pigeon ]
♺ @gridinoc: Brilliant: “Pidgeon: impossible” http://bit.ly/3ziHWr (via @codepo8) [for @common_pigeon ]
Play
Egon Willighagen
Frequency of a Term via PubMed - http://blog.rguha.net/?p=443
Liking this very much! Thanx, Rajarshi! - Egon Willighagen
E.g the rise of "ontology" http://rest.rguha.net/usage... and semantic http://rest.rguha.net/usage... have we reached the peak yet? - Duncan Hull
@Rajarshi a small bug: nothing was displayed with http://rest.rguha.net/usage... whereas the NCBI returns about ~9000 articles http://eutils.ncbi.nlm.nih.gov/entrez... - Pierre Lindenbaum
the site is a little slow, but a while ago I saw this tool for looking at PubMed trends on the internets: http://www.cotch.net/assed... - Michael Kuhn
@Pierre, thanks for the catch. I actually do get the correct data. The absence of bars seems to be a limitation of the Google Charts API and the max size of the chart image. If the X-axis is too long, the bars need to be thinner for it to fit into the plot area, and you can only go so thin and then loose readbility. Like I said - this is a quick hack :) Ideally I'd use matplotlib or R as the backend for plotting, but am lazy right now - Rajarshi Guha
interesting, and very cool. One question/comment, does the Google Charts API by default adjust the image so that the x-axis crosses at a non-zero point on the y-axis? I'm sure that breaks one of Tufte's rules about misleading graphs... - Andrew Su
@Andrew - yes. It took me a bit for me to realize that the count for the first year was not always zero! The Charts API does have a way to set the y range, but I'm going via the pygooglechart Python module which doesn't seem to support that. - Rajarshi Guha
i was about the link to my pubmed trends tool, but i see it has already been done :) it is indeed slow -- a clunky php proof of concept really. (it has been especially slow today because apache filled itself with processes that were trying to do i'm not sure what...) http://www.cotch.net/assed... - Joe Dunckley
Frank
Has anybody used an open ID as an affiliation yet on a journal article? If so what is the best way to go about it? - or other alternatives
Sounds interesting... please share your findings later. #openid #publishing #science - Egon Willighagen
I have often pondered about this but always succumbed to the prospect explaining this to the publisher and knowing that they won't accept it... - Jan Aerts
and what became of researcher ID? - george
A message came around our workplace last week, suggesting that we all sign up at Researcher ID. I tried not to spray coffee across the screen. Currently considering my response. - Neil Saunders
@neilfws it is lack of awareness of solutions beyond those presented by vendors I am afraid. Please do respond and cc me in. - suelibrarian
CrossRef was supposed to come out with a beta-version of their "contributorID" this year, IIRC. Can anyone confirm? - Björn Brembs
To muddy the waters further, this message came via linkedin recently: http://www.linkedin.com/groupAn... not sure of that link will work for everyone 'cause linkedin hates sensible permalinks for some reason - Mr. Gunn
Andrew Su
How nice to have a scientific site that doesn't look like it came from 1996. I will note that on Ubuntu 9.04 in Firefox 3.0, I get sluggish scrolling on the home page, but I'll be up to 3.5 soon and I think that should help. Anyway, looks lovely and feels otherwise very usable. Great work. - Chris Lasher
Thanks Chris. Will make a special note to do some testing to see if we can fix that sluggish scrolling... - Andrew Su
Useful that. - John Hogenesch
Paulo Nuin
I cannot begin to describe how absolutely PERFECT this is. - http://www.reddit.com/r...
Mike Chelen
Scratchpads: a data-publishing framework to build, share and manage information on the diversity of life - http://www.biomedcentral.com/1471-21...
"We describe the system architecture and template design of "Scratchpads", a data-publishing framework for groups of people to create their own social networks supporting natural history science. Scratchpads cater to the particular needs of individual research communities through a common database and system architecture. This is flexible and scalable enough to support multiple networks, each with its own choice of features, visual design, and constituent data. Our data model supports web services on standardised data elements that might be used by related initiatives such as GBIF and the Encyclopedia of Life. A Scratchpad allows users to organise data around user-defined or imported ontologies, including biological classifications. Automated semantic annotation and indexing is applied to all content, allowing users to navigate intuitively and curate diverse biological data, including content drawn from third party resources. A system of archiving citable pages allows stable referencing with unique identifiers and provides credit to contributors through normal citation processes." - Mike Chelen from Bookmarklet
pretty slick - Jean-Claude Bradley
Bosco Ho
The bioinformatic-journal/software hydrid - http://boscoh.com/protein...
Yes, yes. Very much like. - Neil Saunders
Bosco, this is a superb idea. Along with starting up a new journal/software hybrid, it will be great if existing journals insist users to submit source code, executable or VM of a bioinformatics software / database / server to a centralized repository like 'biohub.org'. - Khader Shameer
This is a good idea. - Michael Barton
While not linked to an actual repository (but rather, provides a snapshot of the s/w and data for the article), Journal of Statistical Software, does pretty much this - Rajarshi Guha
I would take this further and the article text remains in the revision repo. The reviewers are sent to the article, not the other way around and it can be forked in just the same way the software can - Frank from iPhone
@Frank, this makes sense, since otherwise the paper would be static and refer to old versions. But then this assumes that as the s/w is updated, so is the paper - Rajarshi Guha
@Rajarshi not neccessarily the paper should state which version/revision it refers to. It does not have to keep up with the sw. That is what documentation is for :) - Frank from iPhone
me likey too - Deepak Singh
The more I think about it, the more I think some big-wig bioinformaticians should do a deal with Google Code to edit a journal. That might even align with Google Scholar. - Bosco Ho
@Frank, in that case, why bother with a VCS? Why not just put a tarball with the source code for the version that goes with the paper? - Rajarshi Guha
Great idea, but I can't see it working for data sets. Yes data sets evolve and should track provenance somehow, but having been in and around standards groups for some time now, this is an impossible task for a publishing group to take care of, especially considering the nature of big-data bioinformatics. Plus if goes against best practices for software source control (use factories, don't store your database...) - delagoya
There are some interesting and non-trivial questions around this kind of idea as to what peer review should look like. Should such a journal provide virtualisation environments so that the code can be run? Example data should be a requirement presumably? Are peer reviewers expected to evaluate code "quality". Anyone thoughts on this would be extremely useful...and help guide a project like this into reality. - Cameron Neylon
My answers to Cameron's points: (1) no, (2) yes, sample data would probably be used to run tests which should pass, (3) quality is somewhat subjective - minimum requirement should be that code runs and generates output as expected - but reviewers could certainly suggest code improvement where appropriate. - Neil Saunders
So if the answer to 1) is no, does that mean that you can't necessarily expect referees to actually run the code? Or compile it? Or just that you pick referees appropriately? Or conversely that "refereeing" becomes a process of building up enough positive comments or karma points in the repository...? It seems to me that you want to bring the best of versioning systems and best practice... more... - Cameron Neylon
Referees should certainly be able to run code - I'm just not sure that virtualisation through the web interface is the way to do it. Seems like an additional layer of complexity that might get in the way of making this idea work. - Neil Saunders
@Cameron & Neil: If it could be figured out how to to handle the virtualization (or having remote access to machines), I think that'd be a highly valuable addition to peer review. Easy for me to say (not knowing how to implement it), but I think it's a great goal to strive for. It doesn't seem too crazy to have the journal have a bunch of machines on hand so the authors can remotely upload / install code and referees could then remotely log in to look at and try out code. - Steve Koch
I can't figure out where to jump into this thread. Personally, I think we just need a place to publish locations, i.e. the code is here, data is there and this is the version we used, etc. That must be maintained and being able to maintain that should become part of the funding process. Since funding agencies are the ones who are funding this research they need to include the ability to... more... - Deepak Singh
My feeling is that being able to run the programs somewhere on a server without downloading them is important - but that is very much a user's perspective. I often look at useful things that are made available and just have no clue how to actually make them work. A good range of downloadable executables would probably do the job for me though. Additional question: what are the standards for web services? - Cameron Neylon
Which is why VM's and cloud services are such a big deal for demo's and provenance now. You can package up a VM with the exact stack that you want and make it available, either as a service or a VM you can launch yourself. It's too easy not to do it - Deepak Singh
@Deepak : Cloud + VM is an an interesting combination, but should have an accessible pricing that is affordable to a larger research community - Khader Shameer
I think there should be strict guidelines while reviewing bioinformatics software / database / servers to test the resource. I had a recent experience : a reviewer wrote extensive list of points to reject a server that we developed with out trying what exactly it is doing or to know how does it differs from other existing resources. I strongly support the hybrid journal model, also it... more... - Khader Shameer
Let's talk specifics. VM images are great, but you are tying your release to a particular release of a particular platform. A better approach is to start from a base OS (like a linus distro ISO) and have a set of build instructions for system set up and application building. My favorite of the moment would be Chef. - delagoya
Second, academics love to solve a problem with a novel algorithm and then move on. In fact it is in their best interest to move on after milking a project for all it's worth, publication wise. Maintenance, or even robust testing (couch... Tophat ... cough ... Bowtie .. cough ) is not even on the radar. Frankly I am not so sure it should be. Maintenance requirements may slow the pace of... more... - delagoya
@delagoya, good point. If I have made significant improvements, why update the old paper? better to try for a new paper! - Rajarshi Guha
delagoya, chef's fine too. Find a common medium/mechanism that works for the community. The resources are certainly there. It's a matter of trying things out. As someone I know says, start simple, and iterate - Deepak Singh
Khader, that's where the funding agencies come in. They need to provide mechanisms for sustainable funding here. - Deepak Singh
The nice thing about a hybrid journal is that it might be possible to have new dois/database entries for "significant" updates. Not perhaps just place holding papers as is the case sometimes in the NAR database issue but when something has changed significantly you can get a new paper without needing a new algorithm or service. I like the idea of funding to support "orphan" code and services as well. Make it worth money and people will do it. - Cameron Neylon
Delagoya - as a naive user I disagree. I really don't want to have to build, I want to use in the lowest stress way possible and a hosted VM seems like a good way to enable that - as well as allow for longer term preservation. We may not be able to run linux on future hardware but will probably be able to handle VMs for longer (actually having written that I'm not sure its true - would be interested in more expert perspectives) - Cameron Neylon
I almost missed this discussion. I really like the idea but I wonder how discovery type projects fit in. I mostly use code to look for trends. If anything I might make some predictor to enhance existing data. For these reasons most of what I do is one off scripts around perl and R. Maybe this sort of project does not belong in a bioinformatics journal at all. - Pedro Beltrao
Pedro, great question. Personally, if we included all glue code, small scripts, etc this would be unsustainable and defeat the purpose of peer review as well - Deepak Singh
@Pedro, I don't see a journal/software hybrid as replacing all bioinformatics journals. I think there's a place for journals that discuss pure algorithms and ideas. These would do exploratory type programming. Normal journals service these papers quite well. For me, a hybrid model targets specifically those papers that describe a program that is meant to be used by other people. In that... more... - Bosco Ho
Bosco, you're thinking along the lines of a communications journal aren't you. And then people can go to work on the code if it is on github or something - Deepak Singh
@Deepak. Yep. The disconnect I see is that pragmatically, it's the open-source project that counts. The article in the bioinformatics journal is so that we can get a place-holder to collect citations that contribute to our academic CV. The journal/software hybrid provides the most efficient way to this goal. - Bosco Ho
Very nicely summary of the problem. Really, the whole concept of a journal article about software is stupid. What does an academic article do? Alert people to a new finding/discovery. But in the case of software - well, the software is the finding. And people are "alerted" by finding it on the web, downloading it and using it. As Bosco says, the sole role of an article here is a CV tick - hence the hybrid approach. Non-academic programmers must find all of this very odd. - Neil Saunders
Egon Willighagen
since we have too many already, setting up a #blueobelisk #stackoverflow website... :)
GokceGoksel
Thomas Lemberger
GrrlScientist
A Love Letter to my Beautiful Readers - http://scienceblogs.com/grrlsci...
Wow, indeed. So happy for you, GrrlScientist. - Ayşe E.
:...because people need to know that their actions do have a result, even if it takes years before they bear fruit." yes. - Mickey Schafer
That's wonderful! - Katherine Haxton
thank you for reading! GrrlScientist http://scienceblogs.com/grrlsci... http://twitter.com/GrrlSci... http://profile.to/grrlsci... $upport science education for America's kids http://j.mp/qfaT1 Roosting high up a tree somewhere in Central Park, NYC - GrrlScientist from email
:) GrrlScientist http://scienceblogs.com/grrlsci... http://twitter.com/GrrlSci... http://profile.to/grrlsci... $upport science education for America's kids http://j.mp/qfaT1 Roosting high up a tree somewhere in Central Park, NYC - GrrlScientist from email
thank you! GrrlScientist http://scienceblogs.com/grrlsci... http://twitter.com/GrrlSci... http://profile.to/grrlsci... $upport science education for America's kids http://j.mp/qfaT1 Roosting high up a tree somewhere in Central Park, NYC - GrrlScientist from email
:) GrrlScientist http://scienceblogs.com/grrlsci... http://twitter.com/GrrlSci... http://profile.to/grrlsci... $upport science education for America's kids http://j.mp/qfaT1 Roosting high up a tree somewhere in Central Park, NYC - GrrlScientist from email
Roderic Page
bioGUID: resolving, discovering, and minting identifiers for biodiversity informatics http://www.biomedcentral.com/1471-21... #ebio09
Euan
Hilarious 'the science behind homeopathy' video: http://www.youtube.com/watch... . Incredibly not a spoof.
Hilarious 'the science behind homeopathy' video: http://bit.ly/15G4w2 . Incredibly not a spoof.
Play
Tom Roud
RT @pierrekerner Visiter le monde rapidement http://ssaft.com/Blog...
Tom Roud
RT @Maitre_Eolas Quand on photoshope un politicien dans une photo, la règle d'or, c'est de ne le faire qu'une fois. http://photoshopdisasters.blogspot.com/2009...
Michael Barton
Yann Abraham
getting there with Hilbert curves thanks to http://r-forge.r-project.org/plugins... #rstats
Andrew Perry
There are more yeast researchers than there are yeast genes, but there are still many uncharacterized genes in the yeast genome, often because deleting these genes doesn’t seem to harm the organism in any way. - http://pansapiens.tumblr.com/post...
Bret Taylor
Google Chart API can generate LaTeX equations - http://moultano.blogspot.com/2009...
Google Chart API can generate LaTeX equations
love! - Ashwin Bharambe
Quite useful for some. :) - Daniel Schildt
Yay! - Simon
Am I the only person who absolutely despises Knuth's "Computer Modern" font? I don't know what it is about it, but it just looks awful to me. And I'm one of those people who used TeX for everything including drawing finite automata and analytic tableaux back in college. - Jim Norris
I'm with you, Jim. That's why, following the book _TeX Unbound_, I used other fonts in my LaTeXed thesis. From the colophon: "I used mathinst to make a mathematical font family of Monotype Bembo Semibold (from Agfa-Monotype), MathTime (from Y&Y), Chantilly (from Softmaker, similar to Gill Sans), Typewriter (from the Electronic Font Foundry), and a few others, with which I typeset this dissertation." - Ruchira S. Datta
I always had \usepackage{times} in my LaTeX documents. - Tudor Bosman
Times is almost as bad though. At one point I figured out how to use Adobe Garamond, but it was kind of flaky. - Jim Norris
I didn't like Computer Modern or Times. I used Century Schoolbook for my stuff, I think (\usepackage{newcent}). - Amit Patel
Andrew Lang
Google now indexing thumbs. Final page of solubility book: Solubilities of inorganic and organic compounds: a compilation of ..., Volume 1 By Atherton Seidell
thumb.png
it actually looks like a toe - Jean-Claude Bradley
Correct. Tis pink, looks like a form of shoewear with desert like background to me so, might this be "Toe in the Sahara, with shoe" Featuring Sting and @cromercrox :- http://www.last.fm/music... - Graham Steel
or does this prove Megan Fox made this scan http://www.nydailynews.com/gossip... - Jean-Claude Bradley
Is this already be digitized by typing monkeys? - Egon Willighagen
it is automatically generated Egon - just waiting for me to get the preface done.... - Jean-Claude Bradley
Jean-Claude... you mean, you are getting the data rescued already? - Egon Willighagen
no sure what you mean by rescued Egon - Jean-Claude Bradley
@JC I think Egon is talking about people transcribing the Seidell's solubility book. @Egon I think JC is talking about the ONS solubility book. :) - Andrew Lang
thanks for the clarification Andy - Marshall already uploaded most of the carboxylic acids and aldehydes - yes I was referring to our own book Egon - Jean-Claude Bradley
Ah... JC, sorry... I did not realized you were compiling an own book :) @Andrew... yes, I was talking about transcribing values from the Seidell book... I might know someone who wants to help with that (or at least try it; he's not a chemist)... - Egon Willighagen
My mistake Egon about the confusion with the book - yes we have one coming out soon. As for help with adding data from the Seidell book I think we have most of the relevant compounds. And it would require a chemist to translate the way names were done back then - also much of it requires conversion between g/100g solvent or g/100g solution to molar, etc - Jean-Claude Bradley
Tristan Hambling
Graphic: Evolution: life on Earth is one big extended family - http://twitturls.com/
Graphic: Evolution: life on Earth is one big extended family
cant seem to find the image.. any other link? - Wildcat
Awesome! I think I'm going to have to print that on our poster printer and put it up on my wall at home! - Björn Brembs
Pawel Szczesny
Dear scientist, if you ask me to fax signed copy of a license which has more bytes than your program, I won't use your tool at all.
Majority of software written few years ago isn't available for instant download. You need to print the license, sign it and fax it to the authors. License: 1,6MB pdf; software 180KB executable. - Pawel Szczesny
I think the biggest problem is that often the scientists didn't even want to do that. In many cases it is their institutions that force them to put their software under a cumbersome license. - Lars Juhl Jensen
Paulo Nuin
How much time does this take to set up? [video] - http://www.reddit.com/r...
Mikael Huss
I'd like to extract, for a rather long list of human genes, info on tissues or cell types where they are known to be important in some automated way from literature. Any suggestions for where to start? Extracting Gene Ontology terms will miss many known gene-tissue associations. Is there a text mining tool that can find gene/cell-type associations?
Only starting point that I can suggest is Acembly: see for instance http://www.ncbi.nlm.nih.gov/IEB... - then click "expression tissue" in menu bar at top of page. I don't know how easy it is to mine - there are some downloads available. NCBI GEO Profiles might be another entry point. There are sure to be tissue expression databases but I don't know what they are. - Neil Saunders
Now I think some more, BioGPS (successor to SymAtlas) is also a good start: http://biogps.gnf.org - Neil Saunders
Thanks Neil, AceView is a nice resource that I had forgotten about. I think I can get started by digging there. BioGPS I had already been playing around with. It is also a great resource, but I would like to collect literature mentions of genes in the context of tissue specific activity and/or diseases in addition to expression data. - Mikael Huss
You may want to have a look at HPRD (Human Protein Reference Database) http://www.hprd.org/ . The database is reporting gene - tissue information based on extensive literature curation. - Khader Shameer
Thanks, Khader, another good suggestion. BTW, http://www.proteinatlas.org/ is a nifty resource, but it does not seem to provide any kind of downloads. - Mikael Huss
I'm not sure if there are Genetics/Celluar biology professionals on http://sciencestack.com yet, but you might want to try to ask there. - Jane Breezler
Neil Saunders
How can I download a list of all viruses infecting humans? - http://www.uniprot.org/faq/10
Egon Willighagen
powerful feeling: making commits to #kde #svn #strigi-chemical :)
Duncan Hull
Abstruse Goose: Rite of Passage - http://abstrusegoose.com/
Abstruse Goose: Rite of Passage
#qotd Computer Science Major "WTF, Man. I just wanted to learn how to program video games" - Duncan Hull from Bookmarklet
Too true of computer science majors these days. - Andrew Lang
I like abstractions - Richard Akerman from BuddyFeed
Christopher Harris
trying out Eclipse for the first time.. shaky legs..
what's Eclipse? - laura
free open-source programming-environment. i've been using BlueJ so far, which is like a kids bicycle with support wheels, Eclipse be real bike. - Christopher Harris
Eclipse is well worth the effort and has a lot of very good language specific plugins. I have been using it for a couple of years now and wouldn't use anything else. Feel free to ask if you need any help getting going. - Ian Simpson from twhirl
I've learned Java with eclipse. The editor, the code completion, etc... make the learning Curve exponential. - Pierre Lindenbaum
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